The analysis of contemporary and archival satellite images and archaeological documentations presents the possibility of monitoring the state of archaeological sites in the Near East (for example, Palmyra in Syria). As it will be demonstrated in the case of Upper Egyptian sites, the rapid growth of agricultural lands and settlements can pose a great threat to sites localized on the border of fields and the desert. As a case study, the Qena district was chosen, a region of significance for the history of ancient Egypt. To trace the expansion of agriculture and the development of modern settlements, a synthesis of archival maps (from the last 200 years), and archival and contemporary satellite images was created. By applying map algebra to these documents, it was possible to determine areas which may be marked as “Archaeological Hazard Zones”. The analysis helped to trace the expansion of agricultural areas during the last 200 years and the influence of both—ancient Egyptians and the Nile—on the local landscape.