In modern Chinese novels, disease is a common theme, and different works also show different flavors. This paper mainly studies the metaphors behind the characters' diseases and the characters' morbid psychology in Eileen Chang's three representative works Flowers Wither, Golden Lock and Red Rose and White Roses. Through the research, the author can find that Eileen Chang's disease writing is related to her personal loveless family life experience, her love for tragic aesthetics and the aesthetic tendency of morbid things, and the popularity of medical treatment in society at that time. At the same time, this paper analyzes the cruel living situation of women revealed in the female diseases in his works. Whether it is arranged marriage or new-style marriage, women have lost the right to choice and autonomy in marriage, so the unhappiness of their marriage life is also the main reason for the disease. Finally, through the analysis of specific characters' diseases, the article shows the pathological psychological state of the characters' hearts under the disease in detail, and analyzes the relationship between them. Through the study, the author can find that the disease in Eileen Chang's works is not only as simple as the disease itself, but also shows a social style and the pathological state and psychology of the characters living in it.