Moderate-intensity Aerobic Training Research Articles

Effect of Aerobic Training on Immune and Hormonal Responses to 30 Hours of Sleep Deprivation in Young Women

Background: Sleep deprivation might suppress the immune system by stimulating stress hormones and increasing susceptibility to infection. Objectives: The purpose of this study was to determine the effect of 8 weeks of aerobic training on immune and hormonal responses to 30 hours of sleep deprivation in young women. Methods: In this semi-experimental study, 21 young women aged 20 - 40 years were divided into control (n = 10) and aerobic training (n = 11) groups. The study was conducted in three separate stages. In the first stage, after 30 hours of sleep deprivation, blood sampling was performed. After 2 days, the subjects in the training group followed an aerobic training protocol consisting of 30 - 50 minutes of continuous running 3 days a week for 8 weeks with an intensity of 50 - 65% of the heart rate reserve (HRR). At least 48 hours after the last training session, the subjects in both control and training groups were deprived of sleep for 30 hours, and the blood samples were taken again. Leukocyte counts, serum immunoglobulin A (IgA), immunoglobulin G (IgG), and cortisol concentrations were measured. Results: The results showed that in the aerobic training group, the leukocytes count (P = 0.0001), serum IgA (P = 0.0001), and cortisol (P = 0.023) concentrations decreased significantly, compared to the control group (P < 0.05). However, serum IgG concentrations did not change significantly in both aerobic and control training groups during the intervention period (P = 0.084). Conclusions: According to the results of this study, it can be said that moderate-intensity aerobic training attenuated the disruption of immune and hormonal responses to 30 hours of sleep deprivation in young women.

579-P: Exercise Upregulates Extracellular Vesicles (EVs) Proteins Involved in Immunomodulatory and Mitochondrial Pathways in Human Subjects

Emerging data suggest that single bouts of exercise increase circulating hormones, cytokines, and EVs, and that these circulating factors may play a fundamental role in the beneficial effects of exercise on health. Here, we identify circulating factors in response to both acute exercise and exercise training and determine the effects of nutritional status on these responses. Blood samples were first collected before and immediately after an acute bout of maximal exercise in healthy, lean subjects (N=8, 3M/5F; age=27±2, V̇O2peak=28.4±1.2ml/kg/min). Subjects then completed a 10 wk moderate-intensity aerobic exercise training program (up to 65-70% VO2peak, 4x/week) with the same post-training sample collection. Proteomics (SOMAscan) quantified 1,310 circulating factors. In the untrained state, acute exercise upregulated 196 proteins and after training exercise upregulated only 65 proteins, with 47 proteins simultaneously upregulated in both the untrained and trained state. Interestingly, cellular component analysis showed that 1/3 of these shared proteins are localized in EVs. Next, we determined the baseline effects of exercise training in the fed and fasted state in the absence of acute exercise. Training upregulated 220 and 178 proteins in fed and fasted state, respectively. Exercise training commonly upregulated 120 proteins in the fed and fasted state with 1/3 localized in EVs. Integration using Vesiclepedia of the upregulated proteins in all 4 comparison groups showed 3 upregulated proteins in both acute exercise and training regardless of nutritional status: PPIF, PTPN6, and CLEC1B. These proteins are found in macrophages and neutrophils, and mediate immunomodulatory effects, promote tissue remodeling, and mitochondrial function. As EVs deliver molecules to cells altering their metabolism, they may play an important role in mediating the beneficial effects of exercise and warrant further mechanistic studies. Disclosure M.Vamvini: None. P.Nigro: None. L.Goodyear: None. R.J.W.Middelbeek: Research Support; Novo Nordisk. Funding Daiichi Sankyo; National Institutes of Health (R01DK099511 to L.G.), (5P30DK36836), (F32DK126432), (K23DK114550 to R.J.W.M.); Joslin Diabetes Center (to M.V.); Boston Area Diabetes Endocrinology Research Center (to R.J.W.M.)

Effects of different exercise patterns on drug craving in female methamphetamine-dependent patients: Evidence from behavior and fNIRS

ObjectiveTo explore the effects of short-term moderate-intensity cycle ergometer and aerobic calisthenics training on drug craving and brain activity. MethodsForty female methamphetamine (MA)-dependent patients were randomly assigned to receive 30 min of either moderate-intensity cycle ergometer or aerobic calisthenics training. Before and after exercise, drug-cue exposure task was used to assess changes in subjective drug craving, and functional near-infrared spectroscopy (fNIRS) was used to assess activation of prefrontal cortex. ResultsAfter the intervention, drug craving was significantly decreased in both groups, and activation of frontal polar area (FPA) was significantly decreased in the cycle ergometer group. Functional connectivity between right dorsolateral prefrontal cortex (DLPFC) and FPA in the aerobic calisthenics group was significantly reduced. Pre-exercise levels of drug craving correlated positively with FPA activation. ConclusionBoth short-term moderate-intensity cycle ergometer and aerobic calisthenics training effectively reduced subjective drug craving in female MA-dependent patients. Cycle ergometer training mainly decreased neural activity in FPA, and likely suppressed drug craving by reducing the episodic memory and pleasure experience of drug-related cues. Aerobic calisthenics training reduced functional connectivity between FPA and right DLPFC, and likely helped subjects reduce the motivation for drug-related behavior and inhibit drug craving.

High-intensity interval training versus moderate-intensity continuous training in patients with heart failure: a systematic review and meta-analysis.

The effects of high-intensity interval training (HIIT) in patients with heart failure (HF) remain controversial. This systematic review and meta-analysis aimed to examine the efficacy of HIIT versus moderate-intensity continuous aerobic training (MCT) on exercise tolerance in patients with HF. We searched for studies published up to 4 March 2022 in Embase, MEDLINE, PubMed, and the Cochrane Library with no limitations on data, language, or publication status. We included randomized controlled trials comparing the efficacy of HIIT and MCT on peak oxygen uptake (VO2), as a measure of exercise tolerance. We pooled the data on peak VO2, compared HIIT to MCT, and conducted a sub-analysis if there was heterogeneity in the result.We identified 15 randomized controlled trials with 557 patients. Our meta-analysis showed that participants who underwent HIIT achieved a significantly higher peak VO2 than those who underwent MCT (mean difference 1.46ml/kg/min, 95% confidence interval 0.39 to 2.53; participants = 557; studies = 15; I2 = 65.7%; very low-quality evidence). The meta-regression analysis, conducted as a sub-analysis to explore possible causes of heterogeneity, revealed that the difference in peak VO2 between HIIT and MCT was inversely associated with body mass index (r = - 0.508, p = 0.028, 95% confidence interval - 0.95 to - 0.07).Our systematic review showed that HIIT achieved a higher peak VO2 than MCT in patients with HF. In addition, HIIT may be more effective in improving exercise tolerance in patients with low body mass index.

Aerobic Physical Training Attenuates Oxidative Stress in the Spinal Cord of Adult Rats Induced by Binge-like Ethanol Intake.

Binge drinking is the most frequent consumption pattern among young adults and remarkably changes the central nervous system; thus, research on strategies to protect it is relevant. This study aimed to investigate the detrimental effects of binge-like EtOH intake on the spinal cord of male rats and the potential neuroprotective effects provided by moderate-intensity aerobic physical training. Male Wistar rats were distributed into the 'control group', 'training group', 'EtOH group', and 'training + EtOH'. The physical training protocol consisted of daily 30-min exercise on a treadmill for 5 consecutive days followed by 2 days off during 4 weeks. After the fifth day of each week, distilled water ('control group' and 'training group') or 3 g/kg of EtOH diluted at 20% w/v ('EtOH group' and 'training + EtOH group') was administered for 3 consecutive days through intragastric gavage to simulate compulsive consumption. Spinal cord samples were collected for oxidative biochemistry and morphometric analyses. The binge-like EtOH intake induced oxidative and tissue damage by decreasing reduced glutathione (GSH) levels, increasing lipid peroxidation (LPO), and reducing motor neurons (MN) density in the cervical segment. Even under EtOH exposure, physical training maintained GSH levels, reduced LPO, and prevented MN reduction at the cervical segment. Physical training is a non-pharmacological strategy to neuroprotect the spinal cord against oxidative damage induced by binge-like EtOH intake.

The Positive Effect of Four-Week Combined Aerobic–Resistance Training on Body Composition and Adipokine Levels in Obese Females

Obesity is a metabolic disease that is caused by a lack of physical activity and is associated with an increased risk of chronic inflammation. A total of 40 obese adolescent females with an average age of 21.93 ± 1.35 years and average body mass index (BMI) of 30.81 ± 3.54 kg/m2 were enrolled in this study, randomized, and divided into four groups, i.e., control (CTL; n = 10), moderate intensity aerobic training (MAT; n = 10), moderate intensity resistance training (MRT; n = 10), and moderate intensity combined aerobic-resistance training (MCT; n = 10). The enzyme-linked immunosorbent assay (ELISA) kits method was used to analyze the adiponectin and leptin levels between pre-intervention and post-intervention. Statistical analysis was conducted using a paired sample t-test, while correlation analysis between variables used the Pearson product-moment correlation test. Research data showed that MAT, MRT, and MCT significantly increased adiponectin levels and decreased leptin levels compared to the CTL (p ≤ 0.05). The results of the correlation analysis of delta (∆) data showed that an increase in adiponectin levels was significantly negatively correlated with a decrease in body weight (BW) (r = -0.671, p ≤ 0.001), BMI (r = -0.665, p ≤ 0.001), and fat mass (FM) (r = -0.694, p ≤ 0.001) and positively correlated with an increase in skeletal muscle mass (SMM) (r = 0.693, p ≤ 0.001). Whereas, a decrease in leptin levels was significantly positively correlated with a decrease in BW (r = 0.744, p ≤ 0.001), BMI (r = 0.744, p ≤ 0.001), and FM (r = 0.718, p ≤ 0.001) and negatively correlated with an increase in SMM (r = -0.743, p ≤ 0.001). In summary, it can be concluded that our data show that adiponectin levels increased and leptin levels decreased after the intervention of aerobic, resistance, and combined aerobic-resistance training.

Physical Performance and Skeletal Muscle Transcriptional Adaptations Are Not Impacted by Exercise Training Frequency in Mice with Lower Extremity Peripheral Artery Disease.

Exercise training is an important therapeutic strategy for lower extremity peripheral artery disease (PAD). However, the effects of different exercise frequency on physiological adaptations remain unknown. Thus, this study compared the effects of a 7-week moderate-intensity aerobic training performed either three or five times/week on skeletal muscle gene expression and physical performance in mice with PAD. Hypercholesterolemic male ApoE-deficient mice were subjected to unilateral iliac artery ligation and randomly assigned to sedentary or exercise training regimens either three or five times/week. Physical performance was assessed using a treadmill test to exhaustion. Expression of genes related to glucose and lipid metabolism, mitochondrial biogenesis, muscle fiber-type, angiogenesis, and inflammation was analyzed in non-ischemic and ischemic gastrocnemius muscles by real-time polymerase chain reaction. Physical performance was improved to the same extent in both exercise groups. For gene expression patterns, no statistical differences were observed between three or five times/week exercised mice, both in the non-ischemic and ischemic muscles. Our data show that exercising three to five times a week induces similar beneficial effects on performance. Those results are associated with muscular adaptations that remain identical between the two frequencies.

Optimal Intensity and Duration of Walking Rehabilitation in Patients With Chronic Stroke

For walking rehabilitation after stroke, training intensity and duration are critical dosing parameters that lack optimization. To assess the optimal training intensity (vigorous vs moderate) and minimum training duration (4, 8, or 12 weeks) needed to maximize immediate improvement in walking capacity in patients with chronic stroke. This multicenter randomized clinical trial using an intent-to-treat analysis was conducted from January 2019 to April 2022 at rehabilitation and exercise research laboratories. Survivors of a single stroke who were aged 40 to 80 years and had persistent walking limitations 6 months or more after the stroke were enrolled. Participants were randomized 1:1 to high-intensity interval training (HIIT) or moderate-intensity aerobic training (MAT), each involving 45 minutes of walking practice 3 times per week for 12 weeks. The HIIT protocol used repeated 30-second bursts of walking at maximum safe speed, alternated with 30- to 60-second rest periods, targeting a mean aerobic intensity above 60% of the heart rate reserve (HRR). The MAT protocol used continuous walking with speed adjusted to maintain an initial target of 40% of the HRR, progressing up to 60% of the HRR as tolerated. The main outcome was 6-minute walk test distance. Outcomes were assessed by blinded raters after 4, 8, and 12 weeks of training. Of 55 participants (mean [SD] age, 63 [10] years; 36 male [65.5%]), 27 were randomized to HIIT and 28 to MAT. The mean (SD) time since stroke was 2.5 (1.3) years, and mean (SD) 6-minute walk test distance at baseline was 239 (132) m. Participants attended 1675 of 1980 planned treatment visits (84.6%) and 197 of 220 planned testing visits (89.5%). No serious adverse events related to study procedures occurred. Groups had similar 6-minute walk test distance changes after 4 weeks (HIIT, 27 m [95% CI, 6-48 m]; MAT, 12 m [95% CI, -9 to 33 m]; mean difference, 15 m [95% CI, -13 to 42 m]; P = .28), but HIIT elicited greater gains after 8 weeks (58 m [95% CI, 39-76 m] vs 29 m [95% CI, 9-48 m]; mean difference, 29 m [95% CI, 5-54 m]; P = .02) and 12 weeks (71 m [95% CI, 49-94 m] vs 27 m [95% CI, 3-50 m]; mean difference, 44 m [95% CI, 14-74 m]; P = .005) of training; HIIT also showed greater improvements than MAT on some secondary measures of gait speed and fatigue. These findings show proof of concept that vigorous training intensity is a critical dosing parameter for walking rehabilitation. In patients with chronic stroke, vigorous walking exercise produced significant and meaningful gains in walking capacity with only 4 weeks of training, but at least 12 weeks were needed to maximize immediate gains. ClinicalTrials.gov Identifier: NCT03760016.

An 8-week exercise study to improve cancer treatment related fatigue and QOL among African American breast cancer patients undergoing radiation treatment: A pilot randomized clinical trial

Cancer treatment related fatigue (CTRF) is one of the most debilitating side effects of adjuvant radiation therapy (RT). Several studies have found that physical activity (PA) may be an effective intervention to decrease fatigue and enhance QOL in cancer survivors. The primary objective of the PEDLAR study is to test the feasibility of an easily administered 8-week structured moderate-intensity PA intervention, delivered concurrently with RT, in reducing CTRF and improving health-related QOL among African-American breast cancer patients. This study is also designed to provide pilot data on the acceptability and adherence of PA interventions in African-American women with breast cancer. It is a prospective, 2-arm, 8-week feasibility trial. Participants are randomized to either a structured, moderate-intensity aerobic training exercise regimen concurrent with radiotherapy or a control group. Participants in intervention group reported high satisfaction with exercise and adherence was >75% for exercise sessions. African-American breast cancer patients in a moderate-intensity 75 min/wk aerobic exercise intervention had marginally lower fatigue at 8-wk follow-up compared to baseline. The control group participants had marginally higher fatigue at 8-wk follow-up compared to baseline. Participants in the intervention group reported slightly better quality of life at 8-wk follow-up compared to baseline (P = 0.06).

The Effect of Eight Weeks of Aerobic Training and Probiotic Supplementation on Body Composition, Insulin Resistance and Glycosylated Hemoglobin in Inactive Obese Women

Background and Objectives Obesity is a multifactorial disease including genetics, lifestyle and gut dysbiosis. The aim of this research was to investigate the effects of eight weeks of aerobic training and probiotic supplementation on body composition, insulin resistance and glycosylated hemoglobin in inactive obese women. Subjects and Methods In this semi-experimental research, 32 middle-aged women with first-degree obesity were selected by purposive sampling and randomly divided into four groups: Exercise, Supplement, Combination, and Control. The exercise intervention consisted of eight weeks of moderate-intensity rhythmic aerobic training (60-75% of heart rate reserve) on three days of the week. The supplement and combination groups took 2 capsules of Familact probiotics from Bio Ferment Company daily, and the training and control groups received a placebo. Results A significant decrease was observed in insulin resistance, weight, and body fat percentage in the intervention groups compared to the control group (P < 0.05). Also, the reduction of insulin resistance in both training and combination groups was significantly higher than in the supplement group (P < 0.05). The reduction of HbA1C in the combined group was significant compared to the other groups (P<0.05). Also, the reduction in body fat percentage was significantly higher in the combined group than in the supplement group (P<0.001). Conclusion Both exercise and the use of probiotics have positive effects on the body composition and metabolism in obese women, and the use of both methods has better effects.

Aerobic exercise reverses the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin to alleviate post-stroke depression.

Post-stroke depression (PSD) is one of the most common and serious sequelae of stroke. The pathogenesis of PSD involves both psychosocial and biological mechanisms, and aerobic exercise is a potential therapeutic target. We conducted an in-depth exploration of the protective mechanisms of aerobic exercise in a PSD mouse model. In this study, C57BL/6 mice were used as the research objects, and a PSD mouse model was established by combining middle cerebral artery occlusion and chronic unpredictable mild stimulation. Real-time quantitative polymerase chain reaction, enzyme-linked immunosorbent assays, adeno-associated virus microinjection technology, co-immunoprecipitation, fluorescence in-situ hybridization, and western blotting were performed. A moderate-load treadmill exercise was used for aerobic exercise intervention. The moderate-intensity aerobic exercise training method adopted 0 slopes and treadmill adaptation training for 5 days. We verified the effects of aerobic exercise on the nuclear factor kappa B (NF-κB)/nucleotide-binding oligomerization domain--like receptor protein 3 (NLRP3) inflammasome/5-hydroxytryptamine (5-HT) pathway. Aerobic exercise effectively alleviated the neurological damage caused by PSD (P<0.01). The results from the PSD mouse model in vivo were consistent with those of the cell experiments. Moreover, overexpression of irisin improves depression-like behavior in PSD mice. We confirmed that aerobic exercise is involved in PSD through 5-HT, which inhibits NF-κB/NLRP3 inflammasome initiation through irisin and alleviates mitochondrial damage under stress by reducing calcium overload, thereby inhibiting NLRP3 inflammasome activation. Aerobic exercise reversed the NF-κB/NLRP3 inflammasome/5-HT pathway by upregulating irisin expression to alleviate PSD.

Topline Results of EXERT: Can Exercise Slow Cognitive Decline in MCI?

AbstractBackgroundThe EXERT trial (NCT02814526) was a Phase 3, multicenter, randomized single‐blind study that examined the effects of regular exercise on cognition and other measures of brain function in a planned sample of 300 older adults with amnestic mild cognitive impairment (MCI).MethodThe Alzheimer’s Disease Cooperative Study (ADCS) coordinated the trial, in partnership with Wake Forest and the YMCA of the USA. Participants were randomized to moderate intensity aerobic training (AX), or to stretching, balance and range of motion (SBR) for 18 months. In the first 12 months, exercise was supervised 2x/week and completed independently 2x/week. All exercise was unsupervised in Months 13‐18. Outcomes assessments were completed at baseline and every 6 months. The primary endpoint was 12‐month change from baseline on the ADAS‐Cog‐Exec, a validated measure of global cognitive function. In addition, 12‐month changes in the ADAS‐Cog‐Exec and CDR‐SB were compared for EXERT intervention groups relative to other cohorts to estimate effects of intervention versus no intervention (i.e., “Usual Care”).Result296 participants were enrolled, and over 31,000 exercise sessions were completed during the first 12 months. Attendance remained high (AX: 81%; SBR: 87%), and &gt;60% of participants reported continued exercise through the pandemic. Neither the AX group nor the SBR group showed 12‐month declines on the ADAS‐Cog‐Exec and CDR‐SB. There were no significant treatment differences between AX and SBR on these outcomes. In the Usual Care analysis comparing ADNI‐1 and EXERT participants matched on key variables (demographics, baseline cognitive function, APOE4), ADNI‐1 MCI participants showed the expected 12‐month decline on the ADAS‐Cog‐Exec, but the EXERT AX and SBR groups did not (ADNI‐1 vs. AX: p = 0.012; vs. SBR: p = 0.00049).ConclusionGlobal cognitive function did not change over 12 months of follow‐up for MCI participants in EXERT, suggesting that both the AX and SBR interventions may have stalled cognitive decline. EXERT is the longest exercise trial conducted in MCI to date, and greater ‘volume’ of exercise may have provided more protection, regardless of exercise intensity. Both groups received equal amounts of weekly socialization, which may have contributed to this protection. Our results are noteworthy given that trial was conducted during the COVID‐19 pandemic.

Blood flow restriction accelerates aerobic training-induced adaptation of {dot{text{V}}}{text{O}}_{2} kinetics at the onset of moderate-intensity exercise

It is unclear whether blood flow restriction (BFR) accelerates the adaptation of the time constant (τ) of phase II oxygen uptake ( {dot{text{V}}}{text{O}}_{2} ) kinetics in the moderate-intensity exercise domain via moderate-intensity aerobic training. Therefore, healthy participants underwent moderate-intensity [45–60% {dot{text{V}}}{text{O}}_{2} Reserve] aerobic cycle training with or without BFR (BFR group, n = 9; CON group, n = 9) for 8 weeks to evaluate {dot{text{V}}}{text{O}}_{2} kinetics during moderate-intensity cycle exercise before (Pre) and after 4 (Mid) and 8 (Post) weeks of training. Both groups trained for 30 min, 3 days weekly. BFR was performed for 5 min every 10 min by applying cuffs to the upper thighs. The τ significantly decreased by Mid in the BFR group (23.7 ± 2.9 s [Pre], 15.3 ± 1.8 s [Mid], 15.5 ± 1.4 s [Post], P < 0.01) and by Post in the CON group (27.5 ± 2.0 s [Pre], 22.1 ± 0.7 s [Mid], 18.5 ± 1.9 s [Post], P < 0.01). Notably, the BFR group’s τ was significantly lower than that of the CON group at Mid (P < 0.01) but not at Post. In conclusion, BFR accelerates the adaptation of the {dot{text{V}}}{text{O}}_{2} kinetics of phase II by moderate-intensity aerobic training.

Comparison between low, moderate, and high intensity aerobic training with equalized loads on biomarkers and performance in rats

This study investigated the physiological and molecular responses of Wistar Hannover rats, submitted to three 5-week chronic training models, with similar training loads. Twenty-four Wistar Hanover rats were randomly divided into four groups: control (n = 6), low-intensity training (Z1; n = 6), moderate-intensity training (Z2; n = 6) and high-intensity training (Z3; n = 6). The three exercise groups performed a 5-week running training three times a week, with the same prescribed workload but the intensity and the volume were different between groups. An increase in maximal speed was observed after four weeks of training for the three groups that trained, with no difference between groups. Higher rest glycogen was also observed in the soleus muscle after training for the exercise groups compared to the control group. We also found that the Z2 group had a higher protein content of total and phosphorylated GSK3-β compared to the control group after five weeks of training. In conclusion, the present study shows that five weeks of treadmill training based on intensity zones 1, 2, and 3 improved performance and increased resting glycogen in the soleus muscle, therefore intensity modulation does not change the training program adaptation since the different program loads are equalized.

The Effect of a Gym- and Home-based Training on Plasma TXNIP Level, Insulin Sensitivity, and Lipid Profile in Hypertensive Men: A Randomized Controlled Trial

Background: Thioredoxin-interacting protein (TXNIP) is a possible factor in the relationship between metabolism and cellular redox state and plays a key role in the regulation of glucose and lipid metabolism. Objectives: The present study aimed at evaluating the effects of combined training in the gym and at home on TXNIP plasma level, insulin sensitivity, and lipid profile in men with primary hypertension. Methods: In this randomized controlled trial, forty-six hypertensive men (age 48 ± 9 years, BMI 30 ± 4 kg/m2) were randomly assigned to the gym-based training (GBT: ten weeks, four days/week of moderate-intensity resistance and aerobic training followed by stretching training), home-based training (HBT: the type, duration, and intensity were similar to the GBT), and control groups. Selected blood biochemical parameters were measured at baseline and after ten weeks of training programs. Results: The plasma levels of TXNIP in the GBT (P = 0.04) and HBT (P = 0.005) groups decreased significantly compared to the control group. Moreover, the levels of plasma total cholesterol and low-density lipoprotein cholesterol decreased and insulin sensitivity increased following GBT compared to the control group (P = 0.03, P = 0.02, and P = 0.01, respectively), with no significant difference observed between GBT and HBT (P = 0.47, P = 0.36 and P = 0.14, respectively). Conclusions: GBT was more effective compared to HBT in positive changes in blood glucose and lipid profile. However, HBT improved some important biochemical parameters and can be an alternative to complementary strategies strategy instead of GBT. Our data manifest that combined training has a positive effect on reducing the protein level, which negatively affects glucose and lipid metabolism in hypertensive men.

Which exercise interventions are more helpful in treating primary obesity in young adults? A systematic review and Bayesian network meta-analysis.

Network meta-analysis was used to evaluate the effectiveness of different exercise interventions in the treatment of obesity in young people and recommend the most suitable exercise method. We searched five electronic databases for articles on obesity treatment in the youth population from inception to April 2022. The two researchers independently retrieved and screened the articles, carried out a quality assessment and data extraction, and carried out a network meta-analysis in the Bayesian framework in Stata software. A total of 32 original studies were included in the study, all randomized controlled trials (RCTs). High-intensity aerobic exercise may be the best way to reduce the weight of obese people; high-intensity aerobic training combined with resistance training may be the best way to reduce BMI and FAT%; moderate-intensity aerobic training combined with resistance training may be the best way to reduce the waistline; high-intensity aerobic exercise may be the best way to boost VO2max. Exercise interventions such as high-intensity aerobic training combined with resistance training can be considered and promoted as a non-drug treatment for primary obesity in young adults.

Performance and Submaximal Adaptations to Additional Speed-Endurance Training Vs. Continuous Moderate-Intensity Aerobic Training in Male Endurance Athletes.

We examined performance and submaximal adaptations to additional treadmill-based speed-endurance training (SET) vs. continuous moderate-intensity aerobic training (MIT) twice / week. Twenty-two male endurance athletes were tested before and after 10-week SET (6-12 × 30-s sprints separated by 3-min rest intervals) and MIT (2040 min continuous running at ~70% maximal oxygen uptake [V̇O2max]). The SET group attained greater acute heart rate (HR) and blood lactate responses than the MIT group (d = 0.86–0.91). The SET group improved performance in a time-to-exhaustion trial, V̇O2max, and lactate threshold (d = 0.50–0.73), whereas no training-induced changes were observed in the MIT group. Additionally, the SET group reduced oxygen uptake, mean HR and improved running economy (d = 0.53–0.86) during running at 10 and 12 km·h-1. Additional SET imposes greater physiological demands than MIT resulting in superior performance adaptations and reduced energy cost in endurance athletes.

Moderate intensity aerobic training reduces the signs of peripheral sensitization in a mouse model of type 2 diabetes mellitus.

Type 2 diabetes mellitus (T2DM) is a global health problem for many reasons including the comorbidities, such as diabetic neuropathy (DPN), which is the most common. It has been suggested that aerobic training can improve metabolic health in individuals with T2DM. Still, the effect of aerobic training on DPN signs and its relationship with serum levels of tumor necrosis tumor alpha (TNF-α), an essential molecule in T2DM development, is unknown. We evaluated the effect of two intensities of aerobic training in adult male C57BL/6 mice divided into six groups: sedentary control (CTRL), control with low-intensity training (CTRL-LI), control with moderate-intensity training (CTRL-MI), T2DM sedentary (T2DM), T2DM with low-intensity training (T2DM-LI), and T2DM with moderate-intensity training (T2DM-MI). We induced the T2DM model by combining a hypercaloric diet and low doses of streptozotocin. We measured serum TNF-α levels and correlated them with peripheral sensitization and the cardinal signs of T2DM in mice. Moderate intensity aerobic training decreased the symptoms of DPN and improved metabolic health in T2DM. Interestingly, decreased TNF-α serum levels correlated with reduced peripheral thermal sensitivity and mechanical sensitivity by aerobic training. Moderate intensity aerobic training counteracts the development and symptoms of DPN and improve metabolic health in T2DM. Decreased TNF-α correlates with reduced peripheral thermal sensitivity and mechanical sensitivity by aerobic training.

The effects of aerobic exercise on body composition in overweight and obese patients with gout: a randomized, open-labeled, controlled trial

BackgroundOverweight and obesity are typical risk factors for the increased prevalence and incidence of gout. The existing guidelines unequivocally indicated that exercise is highly advantageous for patients with gout. Nevertheless, there is still a lack of specific guidance and clinical evidence. The effects of exercise on improving gout, and the optimal frequency, timing, and types of exercise have not been fully clarified. The present trial aims to determine the effects of a specific aerobic exercise program on body composition in overweight and obese patients with gout.MethodsIn this randomized, open-labeled, controlled trial, a total of 60 overweight and obese patients with gout [body mass index (BMI) ≥ 24 kg/m2; age,18–55 years old] are equally randomized (1:1) into two groups (n = 30): moderate-intensity aerobic exercise group (MIAEG), heart rate reserve (HRR) = [(HRmax-HRrest) × 60% intensity] + HRrest, and control group (CG). The moderate-intensity aerobic exercise training program will be conducted for 30–40 min/session and 3 days/week for 12 weeks. Participants in the CG will be asked to avoid making changes in their exercise habits. There will be no limitation in the type of exercise. The primary outcome is the number of patients whose body fat is reduced after 12 weeks. The secondary outcomes include the changes in BMI, waist-to-hip ratio (WHR), insulin resistance index (IRI), serum uric acid (sUA), serum creatinine (SCr), estimated glomerular filtration rate (eGFR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), hepatic steatosis, and adverse effects after 12 weeks. One-way analysis of variance (ANOVA) will be used to compare the mean values of normally distributed variables between MIAEG and GC.DiscussionThe effect and optimal frequency of exercise for improving the status of overweight and obese patients with gout have not yet been determined. We design a 12-week randomized controlled trial and evaluate the effects of individualized aerobic exercise program on patients with gout. The results may assist such patients with a personalized scientific exercise program based on the disease status and motor abilities, so that patients are prone to exercise under the condition of low risk and achieve the greatest benefits.Trial registrationChiCTR2200062153. Registered on July 25, 2022, with ChiCTR. http://www.chictr.org.cn/

Effects Of Aerobic Exercise On BkCa Channels In Arterial Myocytes From Akap150 Smki Mouse

Large-conductance Ca2+-activated K+ channels (BKCa) play a key role in the maintenance of arterial tension. A-kinase anchoring protein 150 (AKAP150) participates in remodeling of ion channels and regulation of vascular tension. However, the role of vascular smooth muscle AKAP150 in aerobic exercise-mediated BKCa channel function is unclear. PURPOSE: To investigate the role of vascular smooth muscle AKAP150 in aerobic exercise-induced arterial and BKCa channel function restoration. METHODS: Using embryonic stem cell targeting technology, we generated the AKAP150 smooth muscle specific knock-in mice (AKAP150 smKI). The wild type (WT) and AKAP150 smKI mice were randomly assigned to sedentary (SED) or exercise (EX) group. WT-EX and AKAP150 smKI-EX were subjected to 12 weeks moderate-intensity aerobic training, and the vascular molecular and functional properties of mice were evaluated after training. RESULTS: The systolic blood pressure (SBP) of 3-month-old AKAP150 smKI mice was higher than that of WT (115.3 ± 0.3 vs. 106.9 ± 0.2 mmHg, p < 0.01). After training, the SBP decreased in AKAP150 smKI-EX (123.9 ± 0.6 vs. 118.4 ± 0.1 mmHg, p < 0.01) and WT-EX (114.1 ± 0.1 vs. 110.1 ± 0.4 mmHg, p < 0.01). AKAP150 smooth muscle specific knock-in significantly reduced the voltage dependence and calcium sensitivity of BKCa channel. Compared with WT-SED, V1/2 enlarged (45.69 ± 1.58 vs. 64.14 ± 2.65 mV, p < 0.01) and Kd increased (0.25 ± 0.09 vs. 1.53 ± 0.49 μmol/L, p < 0.01) in AKAP150 smKI. Aerobic training can effectively reverse these changes, with decreasing V1/2 (55.97 ± 4.30 mV, p < 0.01) and Kd (0.24 ± 0.05 μmol/L, p < 0.01) in AKAP150 smKI-EX. Meanwhile, the expression of AKAP150 was increased (~3.20-fold, p < 0.01), BKCa channel β1 subunit and β1/α subunit ratio were decreased (~0.51; ~0.60-fold, p < 0.01) in AKAP150 smKI-SED. After exercise, the expression of AKAP150 was decreased (~0.69-fold, p < 0.01), β1 subunit and β1/α ratio were increased (~2.08; ~2.43-fold, p < 0.01) in AKAP150smKI-EX. In WT-EX, β1 subunit and β1/α ratio were increased (~1.27; ~1.57-fold, p < 0.01). CONCLUSION: Aerobic training decreases the expression of AKAP150, and so upregulates the expression and function of BKCa channel in VSMCs, leading to the reduction of blood pressure. Supported by the National Natural Science Foundation of China 31771312, 32071174.