Engine lubricants globally face the challenge of meeting the demands of new engine technologies while enhancing energy efficiency and reducing emissions. Lubricants must enhance their performance and sustainability, improve reliability in complex and harsh environments, and minimize environmental impact and health risks. This study explores the influence of two different formulations of low viscosity lubricants, tested through actual road endurance trials, on a hybrid vehicle’s aftertreatment system performance and overall emission levels. The study includes 120,000 km of endurance testing in four different challenging environments in China, as well as 90,000 km of endurance testing in a typical urban and highway driving cycle in a large city. Results indicate that emissions from the test vehicles during the 120,000 km and 210,000 km durable Worldwide harmonized Light vehicle Test Cycles (WLTCs) meet China’s Stage 6 light-duty vehicle emission standards, with the 210,000 km Real Driving Emission test (RDE) results also conforming to these standards. Relative to fresh TWC, the light-off temperature increased by a mere 60 °C, and the oxygen storage capacity declined by around 19% following endurance testing. Additionally, the GPF exhibited satisfactory performance after 210,000 km of endurance testing, showing lower backpressure values compared to the fresh-coated samples, with no notable ash buildup observed in the substrate. Drawing on the outcomes of actual road endurance testing, this study illustrates that employing low-to-mid-ash-content, low-viscosity lubricants is both compatible and reliable for aftertreatment systems in present or advanced hybrid technologies. Premium lubricants facilitate vehicles in sustaining compliant and stable emission performance, even amid harsh environments and complex operating conditions. Furthermore, the tested lubricants effectively inhibit excessive aging of the aftertreatment system over prolonged mileage. Moreover, this study discusses the feasibility of rapid aging evaluation methods for aftertreatment systems based on engine test benches, juxtaposed with actual road endurance testing. These findings and conclusions offer crucial references and guidance for enhancing lubricant performance and sustainability. Subsequent studies can delve deeper into the correlation between lubricant performance and environmental impact, alongside optimization strategies for lubricants across various vehicle models and usage scenarios.