To improve the comfort and smoothness of vehicle driving and reduce the vehicle vibration caused by uneven road surface. In this paper, a new active suspension control strategy is pro-posed by combining a fuzzy neural network and a proportional-integral-derivative (PID) controller, taking body acceleration as the main optimization target and adjusting the parameters of the PID controller in real time. Meanwhile, a fuzzy neural network parameter optimization algorithm combining a particle swarm optimization algorithm and gradient descent method is proposed to realize offline optimization and online fine-tuning of fuzzy neural network parameters. Finally, the active suspension model of a 2-degree-of-freedom 1/4 vehicle is established using MATLAB/Simulink, and the proposed control scheme is verified through simulation studies. The results show that the active suspension system with a particle swarm-optimized fuzzy neural network control method improves the spring mass acceleration, dynamic deflection of suspension, and dynamic tire deformation by 30.4%, 17.8%, and 15.5%, respectively, compared with the passive suspension. In addition, there are also 14.6%, 12.1%, and 11.2% performance improvements, respectively, compared to the PID-controlled active suspension system. These results indicate that the control strategy proposed in this paper can improve the vehicle driving performance and can support the design and development of active suspension systems.