In this article, we presented a novel WO3-FePc day-night dual reaction centers photocatalyst covalently modified by iron-tetra (N-carbonylacrylic) aminephthalocyanine (FePc), in which WO3 as an electron-storage reservoir and FePc as a photosensitizer and Fenton reaction center, which synergistically improve photocatalytic activity. The photocatalytic performance of WO3-FePc was evaluated using Rhodamine B (RhB) as a model pollutant, and it exhibited remarkable efficiency, with degradation of 93.0% RhB achieved under visible light irradiation for 60 min, and 40.4% RhB degraded in the dark, corresponding to approximately 12.4 times the performance of WO3 and 7.8 times that of FePc. In addition, the removal rates of methylene blue (MB), tetracycline hydrochloride (TC•HCl) and K2Cr2O7 (Cr (VI)) by WO3-FePc under visible light were 99.9%, 99.9% and 81.5% in 20 min, respectively. The rapid charge separation and the synergistic effect between the photocatalytic center and the Fenton center lead to excellent photocatalytic performance. This study prepared a highly efficient photocatalyst WO3-FePc that can act continuously during both day and night, and its distinctive day-night dual reaction center provides a new way to overcome the limitations of traditional photocatalytic technology.