Abstract With the change in knowledge production mode, “inter-specialization of drama, film and literature” has become an important cradle of innovation. In this paper, under the perspective of new media, we have constructed an interdisciplinary talent cultivation mode of drama, film, and literature and its quality evaluation index system, and after standardizing the indexes by using the extreme value method, we calculate the index weights of the inter-disciplinary talent cultivation quality evaluation system by using the entropy weight method. Combining the indicators obtained at all levels and the gray correlation analysis method, the quality level of interprofessional talent training in drama, film, and literature is comprehensively evaluated. To further explore the effectiveness of inter-specialty talent cultivation in drama, film, and literature, a quantitative analysis is carried out with the drama, film, and literature major of T College of Arts as an example. The results show that: In the evaluation of talent cultivation quality, the weight values of ideological and moral level and relocatable ability are 0.342 and 0.207, and the overall proximity of the overall level of interprofessional talent cultivation of drama, film, and literature from 2018 to 2022 has been increased by 0.16. The enhancement of the quality of interprofessional talent cultivation of drama, film, and literature needs to break down the current professional barriers, coordinate the planning, share the resources, and collaborate in the cultivation of human beings to ensure that inter-professional education is steadily promoted and the quality of talent cultivation is effectively improved.