The evaluation of decommissioning scenarios is critical to the successful development and execution of a decommissioning project. In the past, many experts have used a physical mock-up system to find the exact work processes and the working positions. Nowadays, these jobs are being done by a Digital Mock-Up (DMU) system. The DMU, which is a technology to realize an effective work process by using virtual environments through representing the physical and logical schema and the behavior of a real decommissioning work, can save on the cost and time, reduce the risk of making later changes, and develop various decommissioning scenarios. In this research, a decommissioning DMU system was developed for simulating the relevant dismantling processes. Decommissioning data-computing modules which can calculate a dismantling schedule, quantify a radioactive waste, visualize a radioactive inventory, estimate a decommissioning cost, and estimate a worker’s exposure were also developed to qualitatively assess the decommissioning information. And an analytic hierarchy process (AHP) model was developed to evaluate the decommissioning scenarios which reflected the quantitative and qualitative considerations. To establish the proper scenario for the thermal column in KRR-1, the developed decommissioning DMU system was applied to evaluate the two candidate scenarios of it.