This research aimed to explanatorily investigate the path and aspect of the inter-regional brain drain of Korean youth for college enrollment and employment utilizing ‘2018 Graduates Occupational Mobility Survey(GOMS) dataset focusing on the Southeast area of Korea. To achieve the purpose of this study, we analyzed the first brain drain which includes the outflow of human resources due to the college entrance, and then the second brain drain involving the regional movement for employment or graduate school entrance. The results of this study showed that there were obviously net outflows of college students from southeast area to metropolitan area, and within the southeast area youths of Ulsan and Kyungnam were more likely to move to Busan for college entrance. Furthermore, there were net outflows of college graduates for employment from southeast area to metropolitan area as well. Meanwhile, the college graduates of Busan were more likely to be employed by the job located in Ulsan and Kyungnam. Based on the above results, this study provided that it is needed to enhance the education, research and student support competency of regional colleges, and establish more assertive ‘affirmative action’ policy to retain regional youth in the original areas.