Two stability-indicating chromatographic methods were developed for the analysis of dapsone in presence of its oxidative degradants. Forced degradation studies were performed on the drug substance using 30% hydrogen peroxide. The degradation products were identified by infrared spectroscopy and mass spectrometry, and a pathway is illustrated. The first method was based on thin-layer chromatographic separation of the drug from its oxidative degradants, followed by densitometric measurement of the intact drug spot at 289 nm. The developing system used for separation is ethyl acetate-toluene in the ratio 1:1 (v/v). The linear range was 0.5–6.0 μg/spot, with mean recoveries of 99.37 ± 0.96%. The second method was based on reversed-phase liquid chromatographic separation of the drug from its oxidative degradants on a C18 column, using the mobile phase methanol-water (65:35, v/v) at the controlled temperature of 25°C. Quantification was achieved by UV detection at 289 nm, based on peak area. The linear range wa...