Μm Pulses Research Articles

Mid-infrared optical parametric amplifier based on a LGSe crystal and pumped at 16 μm

We demonstrate the generation of 22.6 μJ of combined energy at 3 μm for sub-300fs pulses at a repetition rate of 1 kHz using a LGSe optical parametric amplifier (OPA). The LGSe OPA is pumped by the 140-fs 1.6 μm pulses from a 300-mW KTA optical parametric chirped pulse amplifier (OPCPA) based on an all-optical synchronization scheme. By using a highly-nonlinear fiber, the output of an erbium-doped fiber laser operating at 1560 nm is shifted to 1050 nm in order to coherently seed a Nd:YLF regenerative amplifier. The LGSe OPA is seeded using the MIR coming from the amplification of the 1.6 μm in the OPCPA.

Efficient 287 μm fiber laser passively switched using a semiconductor saturable absorber mirror

A passively switched Ho(3+), Pr(3+) codoped fluoride fiber laser using a semiconductor saturable absorber mirror (SESAM) is demonstrated. Q-switching and partial mode-locking were observed with the output power produced at a slope efficiency of 24% with respect to the absorbed pump power. The partially mode-locked 2.87 μm pulses operated at a repetition rate of 27.1 MHz with an average power of 132 mW, pulse energy of 4.9 nJ, and pulse width of 24 ps.

White light generation over three octaves by femtosecond filament at 39 µm in argon

We report the first (to our knowledge) experimental results and numerical simulations on mid-IR femtosecond pulse filamentation in argon using 0.1 TW peak-power, 80 fs, 3.9 μm pulses. A broadband supercontinuum spanning the spectral range from 350 nm to 5 μm is generated, whereby about 4% of the mid-IR pulse energy is converted into the 350-1700 nm spectral region. These mid-IR-visible coherent continua offer a new, unique tool for time-resolved spectroscopy based on a mid-IR filamentation laser source.

Amplification of multi-gigawatt 3 ps pulses in an atmospheric CO_2 laser using ac Stark effect

The 3 ps pulses are amplified to ~20 GW peak power in a TEA CO(2) laser using ac Stark broadening. Demonstration of such broadband coherent amplification of 10 μm pulses opens opportunities for a powerful mid-IR source at a high-repetition rate.

Asynchronous midinfrared ultrafast optical parametric oscillator for dual-comb spectroscopy

Two asynchronous, broadband 3.3 µm pulse trains with a stabilized repetition-rate difference of up to 5 kHz were generated using an ultrafast optical parametric oscillator. The two oscillation channels, each producing ~100 mW average power, ran essentially independently, and weak non-phase-matched sum-frequency mixing between them provided a timing signal that indicated when the asynchronous pulses coincided. The system has immediate applications in incoherent asynchronous optical sampling and, with additional carrier-envelope-offset stabilization, could be applied to coherent dual-frequency-comb spectroscopy.

Femtosecond Carrier Dynamics and Nonlinear Effects in Quantum Cascade Lasers

Quantum cascade lasers (QCLs) are complicated unipolar semiconductor devices based on intersubband transitions and resonant tunneling. In this study, femtosecond mid-infrared (Mid-IR) pulses are employed to investigate the nature of carrier transport through the active and injector regions of a room temperature, pulse biased ultrastrong coupling design QCL. Despite the low average power (<;1 mW) of femtosecond Mid-IR pulses, the efficient coupling of these pulses into the QCL waveguide made the study of nonlinear effects in QCLs possible. Biased just below threshold, we observed ultrafast gain recovery within the first 200 fs mainly contributed by electrons resonant tunneling through a much thinner injector barrier than that of conventional designed QCLs, which overcomes the interface-roughness-induced detuning of resonant tunneling. Oscillation or overshooting within the first picosecond is caused by electron relaxation from continuum region excited by strong pump beam, as well as coherent electron tunneling transport from injector to active region. The former feature is supported by the observation of second harmonic generation (SHG) with emission of λ≈2.2 μm pulses and measured positive photoconductivity. The transport of electrons through the injector region contributes to a slower gain recovery. A much longer recovery (hundreds of picoseconds) can be explained as electrons are depleted from upper stages down to lower stages in real space.

Characterization of the SubstitutedN-Triazole Oxindole TROX-1, a Small-Molecule, State-Dependent Inhibitor of Cav2 Calcium Channels

Biological, genetic, and clinical evidence provide validation for N-type calcium channels (Ca(V)2.2) as therapeutic targets for chronic pain. A state-dependent Ca(V)2.2 inhibitor may provide an improved therapeutic window over ziconotide, the peptidyl Ca(V)2.2 inhibitor used clinically. Supporting this notion, we recently reported that in preclinical models, the state-dependent Ca(V)2 inhibitor (3R)-5-(3-chloro-4-fluorophenyl)-3-methyl-3-(pyrimidin-5-ylmethyl)-1-(1H-1,2,4-triazol-3-yl)-1,3-dihydro-2H-indol-2-one (TROX-1) has an improved therapeutic window compared with ziconotide. Here we characterize TROX-1 inhibition of Cav2.2 channels in more detail. When channels are biased toward open/inactivated states by depolarizing the membrane potential under voltage-clamp electrophysiology, TROX-1 inhibits Ca(V)2.2 channels with an IC(50) of 0.11 μM. The voltage dependence of Ca(V)2.2 inhibition was examined using automated electrophysiology. TROX-1 IC(50) values were 4.2, 0.90, and 0.36 μM at -110, -90, and -70 mV, respectively. TROX-1 displayed use-dependent inhibition of Ca(V)2.2 with a 10-fold IC(50) separation between first (27 μM) and last (2.7 μM) pulses in a train. In a fluorescence-based calcium influx assay, TROX-1 inhibited Ca(V)2.2 channels with an IC(50) of 9.5 μM under hyperpolarized conditions and 0.69 μM under depolarized conditions. Finally, TROX-1 potency was examined across the Ca(V)2 subfamily. Depolarized IC(50) values were 0.29, 0.19, and 0.28 μM by manual electrophysiology using matched conditions and 1.8, 0.69, and 1.1 μM by calcium influx for Ca(V)2.1, Ca(V)2.2, and Ca(V)2.3, respectively. Together, these in vitro data support the idea that a state-dependent, non-subtype-selective Ca(V)2 channel inhibitor can achieve an improved therapeutic window over the relatively state-independent Ca(V)2.2-selective inhibitor ziconotide in preclinical models of chronic pain.

High-power mid-infrared tunable optical parametric oscillator based on 3-mm-thick PPMgCLN

The experimental results of a high-power tunable mid-IR laser are presented. The optical parametric oscillator (OPO) with a 3-mm-thick PPMgCLN crystal was pumped by a 1.064 μm pulse laser. When the pump power of the 1.064 μm laser was 151 W at 10 kHz, and the operating temperature of the PPMgCLN with 5% MgO doping was 100°C, average output power of 23.7 W at 3.91 μm was obtained with a slope efficiency of 18.2% for the idler resonant OPO. The variation of the 3.91 μm output power was about ±4% in 10 min continuous operation. The beam quality factor M 2 was less than 2.6. The average output power of 27.4 W at 3.91 μm was also obtained with 151 W pump power and the slope efficiency of 20.9% for the signal resonant OPO by changing the coating parameters of the OPO cavity mirrors. The mid-IR wavelength tunability of 3.7–4.0 μm can be achieved by adjusting the temperature of a 29 μm period PPMgCLN crystal from 200 to 30°C.

Direct observation of two-color pulse dynamics in passively synchronized Er and Yb mode-locked fiber lasers

We report direct experimental observation of interesting pulse synchronization dynamics in a cavity-combined Er and Yb mode-locked fiber lasers by measuring the relative position between the two-color pulses in the shared fiber section. The influence of the 1.03 μm pulse on the 1.56 μm single pulse as well as bound soliton pairs can be clearly identified as an effective phase modulation through the XPM effect with the walk-off effect taken into account. For the 1.56 μm single pulse under synchronization, the dependence of the relative position variation and the center wavelength shift on the cavity mismatch detuning is found analogous to the typical characteristics of FM mode-locked lasers with modulation frequency detuning. Moreover, depending on the cavity mismatch, the passively synchronized 1.56 μm bound soliton pairs are found to exhibit two different dynamical behaviors, i.e., phase-locked (in-phase) as well as non-phase-locked. The physical origins for these two kinds of bound soliton pairs are investigated experimentally by disclosing their locations with respective to the copropagating 1.03 μm pulse.

Fast ignition integrated experiments with Gekko and LFEX lasers

Based on the successful result of fast heating of a shell target with a cone for heating beam injection at Osaka University in 2002 using the PW laser (Kodama et al 2002 Nature 418 933), the FIREX-1 project was started in 2004. Its goal is to demonstrate fuel heating up to 5 keV using an upgraded heating laser beam. For this purpose, the LFEX laser, which can deliver an energy up to10 kJ in a 0.5–20 ps pulse at its full spec, has been constructed in addition to the Gekko-XII laser system at the Institute of Laser Engineering, Osaka University. It has been activated and became operational since 2009. Following the previous experiment with the PW laser, upgraded integrated experiments of fast ignition have been started using the LFEX laser with an energy up to 1 kJ in 2009 and 2 kJ in 2010 in a 1–5 ps 1.053 µm pulse. Experimental results including implosion of the shell target by Gekko-XII, heating of the imploded fuel core by LFEX laser injection, and increase of the neutron yield due to fast heating compared with no heating have been achieved. Results in the 2009 experiment indicated that the heating efficiency was 3–5%, much lower than the 20–30% expected from the previous 2002 data. It was attributed to the very hot electrons generated in a long scale length plasma in the cone preformed with a prepulse in the LFEX beam. The prepulse level was significantly reduced in the 2010 experiment to improve the heating efficiency. Also we have improved the plasma diagnostics significantly which enabled us to observe the plasma even in the hard x-ray harsh environment. In the 2010 experiment, we have observed neutron enhancement up to 3.5 × 107 with total heating energy of 300 J on the target, which is higher than the yield obtained in the 2009 experiment and the previous data in 2002. We found the estimated heating efficiency to be at a level of 10–20%. 5 keV heating is expected at the full output of the LFEX laser by controlling the heating efficiency.

Surface modification of the titanium implant using TEA CO2 laser pulses in controllable gas atmospheres – Comparative study

Interaction of a TEA CO2 laser, operating at 10.6μm wavelength and pulse duration of 100ns (FWHM), with a titanium implant in various gas atmospheres was studied. The Ti implant surface modification was typically studied at the moderate laser beam energy density/fluence of 28J/cm2 in the surrounding of air, N2, O2 or He. The energy absorbed from the TEA CO2 laser beam is partially converted to thermal energy, which generates a series of effects, such as melting, vaporization of the molten material, shock waves, etc. The following titanium implant surface changes and phenomena were observed, depending on the gas used: (i) creation of cone-like surface structures in the atmospheres of air, N2 and O2, and dominant micro-holes/pores in He ambient; (ii) hydrodynamic features, most prominent in air; (iii) formation of titanium nitride and titanium oxide layers, and (iv) occurrence of plasma in front of the implant. It can be concluded from this study that the reported laser fluence and gas ambiences can effectively be applied for enhancing the titanium implant roughness and creation of titanium oxides and nitrides on the strictly localized surface area. The appearance of plasma in front of the implants indicates relatively high temperatures created above the surface. This offers a sterilizing effect, facilitating contaminant-free conditions.

Improvement of shoot morphogenesis in vitro and assessment of changes of the activity of antioxidant enzymes during acclimation of micropropagated plants of Desert Teak

The aim of the study was to develop an improved and rapid regeneration system via axillary shoot proliferation for Tecomella undulata, an important endangered medicinal tree in India. The Murashige and Skoog (MS) medium augmented with different concentrations (0.1, 0.3, 0.5, 0.7, 1.0, 2.5, 5.0, 7.5 and 10.0 μM) of Thidiazuron (TDZ) was tested for the ability to induce axillary shoot development from cotyledonary node explants excised from 7-day-old sterile seedlings. Among the tried concentrations of TDZ, 0.7 μM showed optimum response in inducing maximum number (25.00 ± 2.30) of shoots and shoot length (4.06 ± 0.58 cm) after 3 weeks of incubation. The regenerated shoots when subcultured on MS medium lacking TDZ gave twofold shoot multiplication rate with maximum number (43.00 ± 2.86) of shoots per explant and longer shoot length (7.40 ± 0.34 cm) during the fourth subculture passage. Attempts were also made to study the morphogenetic effect of medium pH and sucrose concentration on axillary shoot induction and proliferation. The highest efficiency of shoot regeneration was recorded in MS medium supplemented with 0.7 μM TDZ and 3% sucrose at pH 5.8 after 3 weeks of culture. Different concentrations of Indole-3-butyric acid (IBA) were tested to determine the optimum conditions for ex vitro rooting of microshoots. The best result was accomplished with IBA (200 μM) pulse treatment given to the basal end of the microshoots for 30 min followed by their transfer in plastic cups containing soilrite and eventually established in natural soil with 80% survival rate. During acclimatization of plants, catalase (CAT) activity increased reaching maximum at 28th day after transplantation, while superoxide dismutase (SOD) activity increased reaching a maximum in the 21 days. Likewise, changes in the glutathione reductase (GR) and Ascorbate peroxidase (APX) were also detected. The observed changes reflect the plant’s capacity to develop antioxidant mechanisms during acclimatization which determine the ability to survive in oxidative stress. The standardized protocol for mass propagation of Tecomella undulata should eliminate the dependence on natural stands of plants for pharmaceutical purposes, and will also serve as a means of conservation as the species is highly overexploited.

Second harmonic generation in quantum cascade lasers pumped by femtosecond mid-infrared pulses

Second harmonic generation (SHG) pulses at λ ∼ 2.25 µm have been obtained from a 4.5 µm quantum cascade laser (QCL) when it is resonantly pumped by transverse magnetic polarized 120 fs, λ = 4.5 µm pulses through the QCL’s front facet at room temperature. The measured SHG spectrum narrows when the bias across the QCL increases due to the electron population re-distribution and subband realignment. The expected quadratic dependence of the SHG with pump power is observed but saturates at higher pump powers. The linear to nonlinear power conversion efficiency is calculated (∼2 µW/W2) and compared with theoretical calculation. This experiment provides an alternative way of investigating the carrier dynamics in QCLs.

THE IMPACT OF PULSE DURATION AND BURN GRADE ON SIZE OF RETINAL PHOTOCOAGULATION LESION

Shorter pulses used in pattern scanning photocoagulation (10-20 milliseconds [ms]) tend to produce lighter and smaller lesions than the Early Treatment Diabetic Retinopathy Study standard 100-ms exposures. Smaller lesions result in fewer complications but may potentially reduce clinical efficacy. It is worthwhile to reevaluate existing standards for the number and size of lesions needed. The width of the coagulated zone in patients undergoing retinal photocoagulation was measured using optical coherence tomography. Lesions of "moderate," "light," and "barely visible" clinical grades were compared for 100, 200, and 400 μm spot sizes and pulse durations of 20 ms and 100 ms. To maintain the same total area as in 1,000 standard burns (100 ms, moderate) with a 400-μm beam, a larger number of 20-ms lesions are required: 1,464, 1,979, and 3,520 for moderate, light, and barely visible grades, respectively. Because of stronger relative effect of heat diffusion with a smaller beam, with 200 μm this ratio increases: 1,932, 2,783, and 5,017 lesions of 20 ms with moderate, light, and barely visible grades correspond to the area of 1,000 standard burns. A simple formula is derived for calculation of the required spot spacing in the laser pattern for panretinal photocoagulation with various laser parameters to maintain the same total coagulated area.

Energy-scalable pulsed mid-IR source using orientation-patterned GaAs

Coherent mid-IR sources based on orientation-patterned GaAs (OPGaAs) are of significant interest in diverse scientific, medical, and military applications. The generation of long-wavelength mid-IR beams in OPGaAs using optical parametric oscillation exhibits limitations in the obtainable pulse energy and peak power. The master oscillator power amplifier concept is demonstrated in OPGaAs, by which a mid-IR source based on optical parametric oscillation can be scaled to high energy by amplification of the output of the optical parametric oscillator in an optical parametric amplifier (OPA). A fivefold increase in the pulse energy is obtained using this method by amplifying 3.85μm pulses in an OPGaAs OPA pumped by a Th,Ho:YLF Q-switched laser.

Doubly Q-switched GdVO 4/Nd:GdVO 4 laser with AO modulator and Cr 4+:YAG saturable absorber under direct 879 nm diode pumping to the emitting level

In this letter, a doubly Q-switched 1.06 μm pulse laser with AO modulator and Cr 4+:YAG saturable absorber by direct pumping grown-together composite GdVO 4/Nd:GdVO 4 crystal is demonstrated for the first time. Compared to purely AO Q-switching, the simultaneous use of AO Q-switch and Cr 4+:YAG saturable absorber can generate shorter pulses and more symmetric temporal profiles. The thermal lens effect of laser crystal was analyzed.

Sum-Frequency Generation of High-Energy and High-Beam-Quality Ultraviolet Pulses

Sum-frequency generation of UV pulses exceeding 25 mJ and with beam quality has been demonstrated by mixing the third harmonic pulses of a flash lamp pumped 1.06 μm Nd:YAG laser with 1.7 μm pulses from an optical parametric oscillator pumped by the same laser in a compact setup.

Regenerative amplification of picosecond 10-μm pulses in a high-pressure optically pumped CO2 laser

A model is developed and numerical calculations are performed for the regenerative amplification of seed picosecond 10-μm radiation pulses in a high-pressure optically pumped CO2 laser. It is established that by varying the cavity parameters, the conditions of efficient regenerative amplification may be optimised for the case of a relatively short-duration (50 ns) solid-state Cr:Er:YSGG laser and 'long-duration' (250 ns) electrodischarge chemical HF laser. It is shown that the schemes of a CO2 amplifier with optical pumping presented allow obtaining the pulses with the duration of 3ps, output energy of 1–5 mJ, and peak power of ∼1 GW at the pump energy of 150–200 mJ.

Improved sensitivity of terahertz detection by GaAs photoconductive antennas excited at 1560 nm

The terahertz detection by photoconductive antennas (PCAs) based on low-temperature grown (LTG) GaAs with 1.5 μm pulse excitation was revisited. We found that the detection efficiency can be improved by a factor of 10 (20 dB) by reducing the excitation spot size and the gap length of the PCA, maintaining the low noise feature of the PCA on LTG GaAs. As a result, the signal-to-noise ratio higher than 50 dB was obtained at a reasonable incident power of 9.5 mW, suggesting that the scheme is promising for the detection of terahertz waves in practical time domain systems.

Generation of 13.9 µm radiation from CO2 by cascade lasing or externally applied CO2 laser

13.9 µm radiation from the 1000-0110 transition can be obtained from a CO2 laser by saturating the 0001-1000, 10.6 µm transition with an internally generated q-switched pulse or by the application of an external 10.6 µm pulse. Because of Fermi resonance between the symmetric stretch and the bending modes, decay of population from the 1000 level is fast, and such lasers operate at low power and energies. A theoretical model was developed to study such lasers. The results of the calculations indicate that a large-aperture E-beam-sustained discharge is effective for excitation of the cryogenically cooled gain medium, which uses He rich mixture at low pressure. The system is scalable and capable of generating large powers and energies.