Ml Of Alcohol Research Articles

Alcohol in cough medicines hazard to disulfiram user.

To the Editor.— The use of disulfiram (Antabuse) as an adjunct to alcoholism treatment programs is well known in this country, and may be increasing. 1 The minimal dose of alcohol necessary to evoke a reaction in the disulfiram treated patient is somewhat controversial, 2 although it has been suggested that as little as 7 ml of alcohol may cause typical reactions. 3 Thus, in disguised forms, alcohol could represent a serious hazard for patients receiving disulfiram. Our experience with a patient who had a disulfiram-alcohol reaction following the ingestion of a single dose of an over-the-counter, widely advertised cough medication, containing 25% alcohol, serves to emphasize the dangers of alcohol-containing preparations in these unique patients. Report of a Case.— The patient, a 46-year-old white man, was admitted to the hospital because of the abrupt onset of nausea, vomiting, and flushing of several hours' duration. He had been a heavy

FATAL POISONING WITH PODOPHYLLUM RESIN.

<h3>To the Editor:—</h3> I read with interest the communication, "Podophyllum Resin Poisoning With Complete Recovery" (<i>JAMA</i><b>189:</b>639 [Aug 24] 1964), by Balucani and Zellers. Their case being only the fifth case of podophyllum resin poisoning in the literature, I would like to report a short history of another, this one a legal matter for which all records were sent to me by the Turkish health authorities. The patient was a 45-year-old woman with a Krukenberg tumor of the ovary. The entire abdomen was infiltrated by metastases and the tumor was considered inoperable. To test the antitumoral effect of podophyllum resin, the physician in charge injected intravenously 6 ml of a podophyllum resin solution (1.5 gm of podophyllum resin in 100 ml of alcohol). The patient died a short time later. She had received 90 mg of podophyllum resin, and chemical analysis showed that this amount of the resin contains

Al合金中のSi迅速容量定量法

Normally Si in Al alloy and Al-Si alloy is determined gravimetrically or, in certain cases, colorimetrically, but the former is a time-consuming method and the latter is not suitable for high silicon alloy. The method presented here consists of formation of K2SiF6 and its titration with alkali according to the following new analytical procedure. Transfer 0.2 to 0.5 g of the sample to a 300 mL polyethylene conical beaker. Add 60 mL of hot (1:1) HNO3 and 5 mL of HF. Dissolve the sample without heating and dilute with water to 100 mL. Cool rapidly to 20°C and add KNO3 until the solution is saturated. Filter through No. 5A filter paper with a polyethylene funnel. Wash with cold washing solution (dissolve 150 g. KNO3 in 850 mL of distilled water, add 150 mL of alcohol, and then cool to below 20°C until the washings are acid-free. Transfer the paper and the precipitate to a 500 mL conical beaker, add 200 mL of carbon dioxide-free boiling water, shake thoroughly, and titrate while still hot with NaOH solution, using 5 drops (3%) of phenolphthalein indicator, until a faint pink color appears. Deduct the blank from the main titration. 1 mL of 0.5 N NaOH\fallingdotseq0.3508%Si. With Al alloys, this method is only interfered by Ti, Ta and Zr; consequently, as long as these elements do not exceed 0.5% of the sample, succeessful results will be always obtained. Therefore this method can be applied to a number of Al alloys and Al-Si alloys, Furthermore, this method is more rapid, simple and accurate than the usual method and the whole procedure can be carried out within 50 minutes. Hence, this method is a very suitable method for the purpose of industrial routine analysis.