Mixed Pattern Research Articles

Golden gazes: Gaze direction and emotional context promote prosocial behavior by increasing attributions of empathy and perspective-taking.

Prosocial behavior is fundamental to societies. But when and toward whom do humans act generously? We investigate the impact of a listeners' gaze direction and the emotional context of the story heard on (a) perceptions of their social cognition skills and (b) prosocial decisions toward them. In three experiments (two preregistered, N = 486), human participants witnessed prerecorded video encounters between a listener (visible) and a speaker (audible, not visible). The listener either established eye contact, averted gaze, or showed a mixed gaze pattern (gaze direction), while the speaker told a neutral or negatively valenced autobiographic episode (emotional context). Participants rated the listeners' empathy and perspective-taking after each video and played the trust game (Study 1) or the dictator game (Study 2) with the listener. Replicating previous findings, occasional gaze avoidance, especially during negative narrations, increased attributions of social understanding to the listener. Critically, mediation analyses revealed that listeners perceived as empathic and taking perspective were ultimately treated with more trust and generosity in strategic and nonstrategic economic games, suggesting that social signals and contextual cues can serve as an indication of another's reputation, thereby promoting indirect reciprocity. Last, in Study 3, we show that emotional context, but not listeners' gaze behavior, promoted the spread of generosity toward anonymous, previously unobserved individuals in a dictator game, driven by social cognition skills attributed to the listener. We conclude that social signals and contextual cues can be important drivers of cooperation in societies via mechanisms such as indirect reciprocity and social contagion of generosity. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Suburban Blues: Urbanicity, healthcare service mix and spatial patterns of admissions for depression

Abstract Objectives Medical practice variation is a key target for policy makers aiming to improve the efficiency of healthcare delivery. Studies point to strong regional variation in healthcare utilization in Austria which seems to be a by-product of institutional rules and healthcare service mix rather than variance in epidemiology. Methods We use a set of routine healthcare data on hospital admissions for depressive episodes (ICD-10 F320-F329) of adult Austrian patients from 2009 to 2014 on the municipality level to explore spatial patterns of supply-induced demand by nearby hospitals (“Roemer's law”) in hospital admission rates. The dataset covers 99,844 hospital episodes of 69,555 patients in 2,114 municipalities. We estimate a random effects spatial autoregressive model to regress log hospital admission rates on hospital supply and urbanicity as proxies for the municipalities’ healthcare service mix alongside a set of relevant socio-economic/-demographic characteristics. Preliminary results Hospital admission rates per 1,000 inhabitants in the population for depressive episodes vary strongly between municipalities (min=0, max=37.7, mean=1.9, SD = 1.8). We find higher admission rates in the population of suburban municipalities (0.10, 95%-CI: 0.58 - 0.13) and municipalities with hospitals (0.07, 95%-CI: 0.01 - 0.1), regardless of hospital type and size. The spatial structure suggests positive spill-over effects on the hospital admission rates between neighbouring municipalities. Conclusions Our results suggest that high admission rates are a seemingly suburban phenomenon and that healthcare service mix is a driving factor for admission rates. Though it is not clear whether the regional variation in medical practice reflects under- or oversupply of hospital care, promoting timely access to primary care and early-stage treatments may reduce the burden of avoidable hospitalizations for patients and public budgets, and close a gap of unmet need for care of vulnerable populations. Key messages • Hospital admission rates for depression of adults per 1,000 inhabitants in the population for depressive episodes vary strongly between municipalities. • Hospital supply and urbanicity are major driving factors of the spatial patterns in regional varation of hospital admissions.

Perceived and functional parental health literacy and vaccine hesitancy among Cypriot parents

Abstract Background Assessing the association of perceived health literacy (PHL) and functional health literacy (FHL) with childhood vaccination hesitancy (VH) among parents is important in the context of developing targeted responses given that VH is of increasing public health concern. Methods A cross-sectional study was conducted with a convenience sample of parents of children, aged 6 months to 15 years old, presenting in pediatric primary care centers across 3 Cypriot cities. Participants responded to the HLS-EU-Q47 and the NVS (Newest Vital Sign), a self-rated and performance-based tool of health literacy (HL), respectively. They also completed a questionnaire tapping on attitudes and practices regarding childhood vaccinations. Parents were classified according to the overall and domain-specific PHL and FHL, and associations with VH were explored. Results Amongst 207 parents (82.6% female, 86.0% tertiary education), higher PHL was associated with certain positive attitudes and practices related to childhood vaccination e.g. childhood vaccination according to health science, whereas higher FHL appeared to be associated with certain negative attitudes and practices e.g. more concerns about side effects of vaccines. Lack of accurate information was the only reported vaccination barrier associated with lower PHL (34.28, SD = 7.54 versus 36.51, SD = 7.20 p = 0.04), whereas no vaccination barrier was associated with FHL. No significant associations between PHL and VH were observed. In contrast, higher FHL was associated with VH (p = 0.01) with parents categorized as ‘refusers’ (3.67, SD = 2.64) or ‘hesitant acceptors’ (3.15, SD = 2.74) having higher FHL than parents categorized as ‘delayers’ (2.95, SD = 2.63) or ‘non-hesitant acceptors’ (2.99, SD = 2.42). Conclusions Assessing both PHL and FHL led to a more comprehensive understanding on the influence of parental HL towards childhood vaccination which can guide the design and implementation of interventions to address VH among parents. Key messages • While parental HL is associated with childhood VH, a mixed pattern emerged depending on whether HL was operationalized using a perceived or functional measure. • While health education at clinical and population level are needed to counteract parental VH, the association of parental HL with childhood vaccination attitudes and practices is not straightforward.

Food security and trajectories of childhood overweight: Results from the Growing Up in Scotland Study

Abstract Background Inequalities in childhood obesity have widened since 2010 in Scotland, raising concerns for future adult and child health. Increasing food insecurity may contribute to the trend, however evidence for an association with childhood overweight is mixed. We estimate the association between food insecurity and trajectories of overweight among primary school aged children in Scotland. Methods Data were from 1824 children in the Growing Up in Scotland Study, a nationally representative cohort born 2004/5. Height and weight were measured at ages 4, 6, 8 and 10 years, and classified as overweight/obese using age and sex standardised cut-offs. Observed trajectories included: never, always, increasing, decreasing, and mixed patterns of overweight (including obesity). Associations between household food insecurity, measured at age 2, and overweight trajectory were estimated using multinomial regression (never overweight as baseline), adjusted for area deprivation, lone parenting, and mother education. Results Most children were never overweight (54.8%), while 12.6% were overweight throughout. Children with high household food insecurity (6.2%) had nearly twice the risk of experiencing persistent overweight (including obesity) than those with no food insecurity (RRR 1.84, 95% CI 1.02-3.30). Additional analysis showed an even larger association for persistent obesity (RRR 2.53, 95% CI 1.06-6.08). Risk of experiencing increasing, decreasing or mixed patterns of overweight were also elevated. Associations were similar for boys and girls. Conclusions Food insecurity is associated with persistent childhood overweight and obesity. The cost-of-living crisis has exacerbated barriers to accessing healthy, nutritious food. Interventions to tackle childhood food security are vital to avoid storing up future health inequalities. Key messages • The cost-of-living crisis is exacerbating food insecurity among UK families. • Food insecurity is associated with persistent overweight and obesity during childhood in Scotland.

Lobular-Like Features and Outcomes of Mixed Invasive Ductolobular Breast Cancer (MIDLC): Insights from 54,403 Stage I-III MIDLC Patients.

Mixed invasive ductolobular breast cancer (MIDLC) is a rare histological subtype of breast cancer (BC), with components of both invasive ductal cancer (IDC) and invasive lobular cancer (ILC). Its clinicopathological features and outcomes have not been well characterized. The National Cancer Database 2010-2017 was reviewed to identify women with stage I-III BCs. Univariate analysis was performed using Chi-square or Wilcoxon rank-sum tests and multivariable analysis with logistic regression to predict surgical decisions. Survival was assessed using multivariable Cox proportional hazards regression analysis. We identified 955,828 women with stage I-III BCs (5.7% MIDLC, 10.3% ILC, and 84.0% IDC). MIDLC was more like ILC than IDC in terms of multicentricity (14.2% MIDLC, 13.0% ILC, 10.0% IDC), hormone receptor positivity (96.6% MIDLC, 98.2% ILC, 81.2% IDC), and use of neoadjuvant chemotherapy (NAC; 5.8% MIDLC, 5.2% ILC, 10.8% IDC). 744,607 women underwent upfront surgery. The mastectomy rates were 42.3% for MIDLC, 46.5% for ILC, and 33.3% for IDC (all p<0.001). With 5.5 years of median follow-up, the adjusted overall survival in the upfront surgery hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) biological subgroup was better in MIDLC (hazard ratio 0.88, p<0.001) and ILC (hazard ratio 0.91, p<0.001) than in IDC. Like ILC, MIDLC also had a lower pathological complete response to NAC than IDC (12.3% MIDLC, 7.3% ILC, 28.6% IDC). MIDLC displays a mixed pattern of characteristics favoring features of ILC compared with IDC, with favorable 5-year overall survival compared with IDC within the HR+/HER2- subtype who underwent upfront surgery.

Uncovering the global ranking of greenhouse gases intensity, efficiency and structural transformation

This study incorporated the index decomposition analysis to drive the GHGs emissions intensity and separate the impact into true efficiency and structural transformation of economic activities on GHGs emissions. The global perspective is investigated in three aspects; (i) global groups of countries regarding income level, (ii) global countries bifurcated into geo-political regions and, (iii) hundred countries are taken to perform individual country level analysis, by taking 20 years (2000–2019) data. The hundred countries are ranked regarding GHGs intensity, efficiency and economic activities with respect to (i) for the latest year performance, (ii) twenty years average performance and, (iii) annual average reduction of GHGs emissions, comparable with base year 2000. Income-based countries groups explicate the improvement of GHGs intensity for HIC only and the economic transformation contributed to it. Efficiency index for all income groups while economic activities of LMIC, MIC and UMIC deteriorated the GHGs emissions. Global geo-political regions explicate the mixed pattern of GHGs intensity. Efficiency index is best for Azerbaijan and least for Uzbekistan. While ranking average GHGs emission reduction countries; Zimbabwe is the best and Qatar is the last country in the intensity list.

Vertical distribution of groundwater age in and around the freshwater–saltwater transition zone determined using noble gases and carbon isotopes

The distribution of groundwater ages in coastal aquifers are complicated because of the heterogeneity of the hydrogeology and the mixing of terrestrial and marine water sources. Therefore, multiple studies verifying the groundwater age distribution via borehole surveys are required to better understand groundwater flow in coastal aquifers. This study examined groundwater age distributions in coastal aquifers adjacent to a high-elevation volcano (Mt. Fuji, Japan) by analyzing geochemical and isotopic tracers retrieved from drilling 350- and 160-m-deep boreholes. Brackish groundwater samples collected from the boreholes had high helium isotope ratios, indicating a large contribution of mantle-derived helium. Groundwater ages determined from carbon and helium isotopes indicate that terrestrial groundwater recharged at high elevations flows from the volcano to the coast, mixing with seawater in a transition zone. The groundwater age at the freshwater–saltwater transition zone and the upper part of the saltwater zone is older than that of the underlying saline water. The distributions of the groundwater age in the study area confirm that the conventional groundwater flow system in coastal aquifers is applicable even in deep aquifers. The complex patterns of groundwater age and mixing derived from geochemical and isotopic tracers can guide sustainable use of groundwater resources and the subsurface.

Computed tomographic imaging features to differentiate gastric schwannomas from gastrointestinal stromal tumours: a matched case–control study

To investigate clinical data and computed tomographic (CT) imaging features in differentiating gastric schwannomas (GSs) from gastric stromal tumours (GISTs) in matched patients, 31 patients with GSs were matched with 62 patients with GISTs (1:2) in sex, age, and tumour site. The clinical and imaging data were analysed. A significant (P < 0.05) difference was found in the tumour margin, enhancement pattern, growth pattern, and LD values between the 31 patients with GSs and 62 matched patients with GISTs. The GS lesions were mostly (93.5%) well defined while only 61.3% GIST lesions were well defined.The GS lesions were significantly (P = 0.036) smaller than the GIST lesions, with the LD ranging 1.5–7.4 (mean 3.67 cm) cm for the GSs and 1.0–15.30 (mean 5.09) cm for GIST lesions. The GS lesions were more significantly (P = 0.001) homogeneously enhanced (83.9% vs. 41.9%) than the GIST lesions. The GS lesions were mainly of the mixed growth pattern both within and outside the gastric wall (74.2% vs. 22.6%, P < 0.05) compared with that of GISTs. No metastasis or invasion of adjacent organs was present in any of the GS lesions, however, 1.6% of GISTs experienced metastasis and 3.2% of GISTs presented with invasion of adjacent organs. Heterogeneous enhancement and mixed growth pattern were two significant (P < 0.05) independent factors for distinguishing GS from GIST lesions. In conclusion: GS and GIST lesions may have significantly different features for differentiation in lesion margin, heterogeneous enhancement, mixed growth pattern, and longest lesion diameter, especially heterogeneous enhancement and mixed growth pattern.

Predicting the formation of mixed pattern hemorrhages in ruptured middle cerebral artery aneurysms based on a decision tree model: A multicenter study

ObjectiveMixed-pattern hemorrhages (MPH) commonly occur in ruptured middle cerebral artery (MCA) aneurysms and are associated with poor clinical outcomes. This study aimed to predict the formation of MPH in a multicenter database of MCA aneurysms using a decision tree model. MethodsWe retrospectively reviewed patients with ruptured MCA aneurysms between January 2009 and June 2020. The MPH was defined as subarachnoid hemorrhages with intracranial hematomas and/or intraventricular hemorrhages and/or subdural hematomas. Univariate and multivariate logistic regression analyses were used to explore the prediction factors of the formation of MPH. Based on these prediction factors, a decision tree model was developed to predict the formation of MPH. Additional independent datasets were used for external validation. ResultsWe enrolled 436 patients with ruptured MCA aneurysms detected by computed tomography angiography; 285 patients had MPH (65.4%). A multivariate logistic regression analysis showed that age, aneurysm size, multiple aneurysms, and the presence of a daughter dome were the independent prediction factors of the formation of MPH. The areas under receiver operating characteristic curves of the decision tree model in the training, internal, and external validation cohorts were 0.951, 0.927, and 0.901, respectively. ConclusionAge, aneurysm size, the presence of a daughter dome, and multiple aneurysms were the independent prediction factors of the formation of MPH. The decision tree model is a useful visual triage tool to predict the formation of MPH that could facilitate the management of unruptured aneurysms in routine clinical work.

Strong reciprocal ratio consensus of modified second-order multi-agent systems with periodically time-varying topologies

The strong reciprocal ratio consensus problem of modified second-order discrete-time multi-agent systems (DTMASs) with periodically time-varying topologies is investigated. The strong reciprocal ratio consensus is a new consensus and covers the strong ratio average-consensus as a special case. Modified second-order DTMAS is a variant of second-order DTMAS. A distributed control protocol is designed to achieve the strong reciprocal ratio consensus and it is the first time that ratio strategy is combined with second-order DTMASs. Furthermore, our work covers several cases where dynamically changing topologies are directed or undirected, connected or disconnected, or even mixed patterns of connected and disconnected graphs.

Pattern dynamics of a harvested predator–prey model

This paper investigates the pattern dynamics of a harvested predator–prey model with no-flux boundary conditions. Firstly, we analyze the positive equilibrium types of the local temporal model. We find that they can be classified as nodes, foci, or centers depending on the harvesting coefficient within a certain parameter range. Furthermore, the direction of the Hopf bifurcation is determined by employing the first Lyapunov coefficient. In the subsequent analysis, we present the conditions for the existence of Turing instability and classify the different pattern selections using amplitude equations with the assistance of weakly nonlinear analysis by treating the harvesting coefficient as a critical parameter. Finally, the spot patterns and mixed patterns are respectively displayed in 2D space, on spherical and torus surfaces with various harvesting coefficient values. Especially, we can numerically demonstrate that the diffusion rate of the prey population will strongly affect the pattern structures of the model. These results can provide a reference for understanding the interaction dynamics of the model.

Effects of experimental warming at the microhabitat scale on oak leaf traits and insect herbivory across a contrasting environmental gradient

Forest microclimatic variation can result in substantial temperature differences at local scales with concomitant impacts on plant defences and herbivory. Such microclimatic effects, however, may differ across abiotically contrasting sites depending on background environmental differences. To test these cross‐scale effects shaping species ecological and evolutionary responses, we experimentally tested the effects of aboveground microhabitat warming on insect leaf herbivory and leaf defences (toughness, phenolic compounds) for saplings of sessile oak Quercus petraea across two abiotically contrasting sites spanning 9° latitude. We found higher levels of herbivory at the low‐latitude site, but leaf traits showed mixed patterns across sites. Toughness and condensed tannins were higher at the high‐latitude site, whereas hydrolysable tannins and hydroxycinnamic acids were higher at the low‐latitude site. At the microhabitat scale, experimental warming increased herbivory, but did not affect any of the measured leaf traits. Condensed tannins were negatively correlated with herbivory, suggesting that they drive variation in leaf damage at both scales. Moreover, the effects of microhabitat warming on herbivory and leaf traits were consistent across sites, i.e. effects at the microhabitat scale play out similarly despite variation in factors acting at broader scales. These findings together suggest that herbivory responds to both microhabitat (warming) and broad‐scale environmental factors, whereas leaf traits appear to respond more to environmental factors operating at broad scales (e.g. macroclimatic factors) than to warming at the microhabitat scale. In turn, leaf secondary chemistry (tannins) appears to drive both broad‐scale and microhabitat‐scale variation in herbivory. Further studies are needed using reciprocal transplants with more populations across a greater number of sites to tease apart plant plasticity from genetic differences contributing to leaf trait and associated herbivory responses across scales and, in doing so, better understand the potential for dynamics such as local adaptation and range expansion or contraction under shifting climatic regimes.

Differential effects on TDP-43, piezo-2, tight-junction proteins in various brain regions following repetitive low-intensity blast overpressure.

Mild traumatic brain injury (mTBI) caused by repetitive low-intensity blast overpressure (relBOP) in military personnel exposed to breaching and heavy weapons is often unrecognized and is understudied. Exposure to relBOP poses the risk of developing abnormal behavioral and psychological changes such as altered cognitive function, anxiety, and depression, all of which can severely compromise the quality of the life of the affected individual. Due to the structural and anatomical heterogeneity of the brain, understanding the potentially varied effects of relBOP in different regions of the brain could lend insights into the risks from exposures. In this study, using a rodent model of relBOP and western blotting for protein expression we showed the differential expression of various neuropathological proteins like TDP-43, tight junction proteins (claudin-5, occludin, and glial fibrillary acidic protein (GFAP)) and a mechanosensitive protein (piezo-2) in different regions of the brain at different intensities and frequency of blast. Our key results include (i) significant increase in claudin-5 after 1x blast of 6.5 psi in all three regions and no definitive pattern with higher number of blasts, (ii) significant increase in piezo-2 at 1x followed by significant decrease after multiple blasts in the cortex, (iii) significant increase in piezo-2 with increasing number of blasts in frontal cortex and mixed pattern of expression in hippocampus and (iv) mixed pattern of TDP-3 and GFAP expression in all the regions of brain. These results suggest that there are not definitive patterns of changes in these marker proteins with increase in intensity and/or frequency of blast exposure in any particular region; the changes in expression of these proteins are different among the regions. We also found that the orientation of blast exposure (e.g. front vs. side exposure) affects the altered expression of these proteins.

Investigation of driving forces in a phase field approach to mixed mode fracture of concrete

Concrete, with its heterogeneous internal structure of cement mortar and grains, exhibits complex quasi-brittle cracking where a gradual decrease in the material integrity is observed. In practical engineering, concrete structures are commonly under loading conditions that cause complex mixed mode fracture patterns. Hence, the prediction of failure mechanisms and patterns in concrete is a demanding task. In the past decades, computational fracture modeling of concrete has proven to be a suitable substitute for costly experimental testing. Among many fracture models, the phase field approach, owing to its ability to capture various crack phenomena without a need for ad hoc criteria, has gained significant attention. Although there exist phase field models applied to various failure mechanisms ranging from brittle to ductile fractures, only a limited number of them deal with the quasi-brittle cracking observed in concrete. Hence, in this work, a thermodynamically consistent phase field approach for quasi-brittle fracture is presented, and its performance for capturing the mixed mode failure patterns of concrete is investigated. Starting from a purely geometric approach, the evolution of fracture is associated with a constitutive crack driving functional. The crack driving force is related to an equivalent effective stress measure leading to a simple, yet versatile, framework in which various failure criteria can be implicitly incorporated into the framework. In particular, equivalent effective stresses based on the Rankine, Drucker–Prager, modified von Mises, and three-parameter failure criteria are derived. A unified form of the equivalent effective stress encompassing all the models is also proposed, which offers flexibility in choosing an appropriate driving force, and allows a simple implementation into a finite element framework. Utilizing this unified form, the effectiveness of the aforementioned driving forces in capturing complex mixed mode cracking in concrete is investigated by comparing the results obtained from computational simulations to existing experimental data. In particular, the load–displacement curves and the crack propagation paths are compared with the corresponding experimental observations, and a systematic study of the performance of different driving forces is detailed in this study.

Identification of novel angiotensin converting enzyme (ACE) inhibitory peptides from Pacific saury: In vivo antihypertensive effect and transport route

Nature food-derived angiotensin converting enzyme inhibitory peptides (ACEIPs) can be potent and safe therapeutics for many medical illnesses, particularly hypertension. In this study, novel ACEIPs were screened and identified from Pacific saury by bio-activity guided approach through ultrafiltration membrane, Sephadex G-25 and RP-HPLC. The antihypertensive effect of ultrafiltration fraction was confirmed with spontaneous hypertensive rats' (SHRs) model. The peptides sequences of which gave the best activity was identified by Q-Orbitrap-MS/MS and selectively synthesized based on the binding energy of molecular docking. Five peptides VVLASLK, LTLK, LEPWR, ELPPK and LPTEK were synthesized, and the peptide LEPWR (IC50 = 99.5 μM) showed the best ACE inhibitory ability. Furthermore, LEPWR against ACE in a mixed competitive pattern and formed six hydrogen bonds with ACE. Additionally, the apparent permeability coefficient (Papp) of LEPWR was 3.56 ± 0.14 × 10−6 cm/s and paracellular transport across tight junctions was the main pathway across the Caco-2 monolayer. Therefore, the Pacific saury is a good material to prepare ACEIPs, but antihypertensive mechanism of peptide LEPWR on SHRs needs further investigation.

Prevalence of pulmonary arterial hypertension in post-tuberculosis lung fibrosis patients: A cross-sectional observational study

Introduction: Post-tuberculosis (TB) lung fibrosis is an infrequently reported cause of Pulmonary arterial hypertension (PAH). Pulmonary TB still being an important global health problem, especially in developing countries, PAH developing after pulmonary TB deserves attention. This study was undertaken to know the prevalence of PAH among patients with post-TB lung fibrosis. Methods: A cross-sectional observational study was carried out in two tertiary care hospitals in Kolkata over a period of 1 year. Sixty adult post-TB lung fibrosis patients without any cardiovascular or other pulmonary comorbidities were included in this study. Results: Out of the 60 patients with varying degrees of lung fibrosis confirmed radiologically, eight patients were found to have PAH (13.33% of the study population). Among the eight cases, six were males and two were females. Five of the males were smokers with a mean of 17.6 pack years of smoking. Out of the eight diagnosed PAH cases, three were mild PAH, four were moderate, and one case had severe PAH (grading based on 2D echocardiography findings). Pulmonary function test (PFT) revealed obstructive pattern in three cases, restrictive pattern in three cases, and mixed in two cases. On PFT, smokers with PAH exhibited obstructive pattern and mixed pattern, whereas the nonsmoker PAH cases exhibited restrictive pattern. Conclusion: All post-TB lung fibrosis cases must be followed up at regular intervals and screened to rule out PAH. Early diagnosis and prompt treatment of the cases will help to reduce morbidity and mortality of the disease which otherwise has a poor prognosis.

Non-Fickian solute transport in three-dimensional crossed shear rock fractures at different contact ratios

Solute transport in fractured rocks plays a crucial role in many subsurface processes, such as geothermal resource extraction and carbon capture and storage. This study conducted simulations of non-Fickian solute transport at varying contact ratios and voids in crossed shear fractures. Results indicated that increasing the contact ratio of the crossed fractures intensified the “tailing” phenomenon of non-Fickian solute transport, and has a negative relationship with the solute outflow concentration. Additionally, the anisotropy of intersections and the variations in their void structure both influence the redistribution and mixing of fluid and solute, therefore, we propose a method to determine the solute mixing patterns at the intersection. Ultimately, while the volume and magnitude of the separated vortex domain in the flow field can influence the non-Fickian solute transport, the “tailing” phenomenon is more significantly affected by its magnitude.

How to Find a Bitcoin Mixer: A Dual Ensemble Model for Bitcoin Mixing Service Detection

Bitcoin is the first decentralized peer-to-peer cryptocurrency that has gained popularity by providing users with transaction anonymity. With the development of Bitcoin and the higher privacy requirements of users, mixing services have emerged to enhance Bitcoin anonymity by obfuscating the flow of funds. However, they are also widely used for illegal activities due to its strong anonymity, especially for money laundering. Therefore, detecting mixing services has great significance for Bitcoin anti-money laundering. In this paper, we propose a novel detection scheme to identify the addresses belonging to Bitcoin mixing services. Specifically, we first construct the Bitcoin mixing dataset, which summarizes a total of 26 features to describe the transaction behavior of addresses. Next, we design a new classification model, called the Dual Ensemble Classification Model. The model combines the advantages of multiple models based on different algorithms and obtains better classification performance. In order to detect more complex mixing patterns, we also extract transaction sub-graphs from the established Bitcoin address-transaction network. The sub-graphs are then classified using a kernel-based graph classification method, which is embedded in the model. Comprehensive experiments on three datasets demonstrate the effectiveness of our scheme, and the proposed model has a detection accuracy of 99.84% for the Bitcoin mixing service.

Mixing effect on bio-methanation, settleability and dewaterability in the anaerobic digestion of sewage sludge fractions

Biomethanation and dewaterability characteristics of primary sludge (PS), secondary sludge (SS) and mixed sludge (MS) fractions were assessed after anaerobic stabilization under parallel batch and continuous mixing conditions at 35℃ in order to investigate the performance of the separate digestion system. Similar methane conversion/yield values were obtained in PS, SS and MS digestion with continuous mixing’s positive effect only in PS digestion. Continuous mixing resulted in 50% increase in the methane yield (600(+/-100) mL/g VSadd.d. SS digestion produced a comparable methane yield at 650(+/-100) mL/g VSadd.d showing no effect due to mixing pattern. Settling and dewaterability characteristics of the stabilized PS were superior to stabilized SS samples. A reverse relationship was obtained between settling and dewaterability characteristics where intermittent mixing enhanced settling ability while continuous mixing resulted in higher dewaterability of the stabilized sludges. Polyelectrolyte (PE) addition showed a negative effect on the settleability of the sludges. Low degree mixing resulted in 50% sludge volume reduction and an SVI of 64 mL/g VS compared to 25% volume reduction and 82 mL/g SVI in the continuous mixing mode for the stabilized PS. A similar trend for the stabilized SS but weaker values with 25% volume reduction and an SVI 182 mL/g in the intermittent mixing mode compared to 15% volume reduction and 200 mL/g VS SVI indicated a much lower settleability in the continuous mixing mode and compared to stabilized PS.

Prevalence and risk factors of M tuberculosis infection in young people across 14 communities in Zambia and South Africa.

From 2018-2021 the TB Reduction through Expanded Antiretroviral Treatment and TB Screening (TREATS) project took place in 21 Zambian and South African communities. The TREATS Incidence of TB Infection Cohort Study was conducted in adolescents and young people (AYP), aged 15-24 years in 14 communities. We describe the baseline prevalence and risk factors of Mycobacterium tuberculosis (M. tuberculosis) infection among this cohort and explore the quantitative QFT-Plus interferon gamma (IFN-γ) responses. A random sample of approximately 300 AYP per community were recruited and information on TB/HIV risk factors, TB symptoms and social mixing patterns collected. QuantiFERON TB Gold Plus assay (QFT-Plus) was used to detect M. tuberculosis infection, following manufacturer's instructions. Logistic regression was used to determine factors associated with infection. 5577 eligible AYP were invited to participate across both countries, with 4648 enrolled. QFT-Plus results were available for 4529: 2552(Zambia) and 1977(South Africa). Overall, 47.6% (2156/4529) AYP had positive QFT-Plus results, the prevalence of infection in South Africa being twice that in Zambia (64.7% (1280/1977) vs 34.3% (867/2552) p<0.001). Infection was associated with age, household contact with TB and alcohol in Zambia but showed no associations in South Africa. The antigen tube differential (TB2-TB1>0.6 IU/ml) of the assay at baseline showed no evidence of association with recent TB exposure. The high prevalence of infection in AYP warrants urgent action to address TB control, especially in South Africa. Further research is required to delineate antigen tube responses of the QFT-Plus assay more precisely to fully realise the benefit of the additional TB2 tube in high TB/HIV burden settings.