Considering the long-term growth of tourism, the environmental impact of aesthetic waste is necessary to manage sustainably. However, the current municipal solid waste management (MSWM) mostly lacks capacity and excludes the relevant stakeholders to involve tourism waste management comprehensively. Synergy was recruited as an important mechanism for enhancing the current MSWM, which had never been applied previously. Also, the private sector (accommodation and trades) and people sector (residents and tourists) were included in the multi-stakeholder approach for an effective MSWM study. Thus, this study aims to explore the stakeholders of the public sector and relevant stakeholders in beach recreation to find the synergistic opportunities for enhancing MSWM in the eastern region of Thailand. Primary data was gathered by semi-structured interviews and questionnaire surveys, as part of a mixed-methods methodology. Descriptive statistics, chi-square testing, regression, and content analysis were applied for data analysis. The finding shows that, in addition to the challenging, potential, and cross-sector synergy identified in the literature, this study discovered synergistic opportunities with other types of partnership specifically. To shed light on synergy and multi-stakeholder studies, the benefits derived and ecosystem must be indicated to stimulate partnership and enhance the MSWM in coastal tourism destination sustainability.