In this article, the interannual variability of sea ice in the Antarctic sea ice regions between 2013–2018 is studied using a global ocean sea ice coupled model and satellite observation. The numerical model reasonably well simulates satellite observed interannual variability of sea ice concentration (SIC) and sea surface temperature (SST) in the Antarctic regions of Southern Ocean during all four austral seasons; summer (December–February), autumn (March–May), winter (June–August), and spring (September–November).A comparison of satellite and model shows that, during last two decades between 2001–2020, summertime of 2016–2017 had the lowest (highest) SIC (SST) across the Antarctic sea ice regions. Mixed layer heat budget analysis has been performed to comprehend how thermodynamic processes affect changes in SIC and SST in the Antarctic sea ice regions. The strong positive net atmospheric heat flux and the negative ocean vertical entrainment during summertime of 2016–2017 resulted in increased SST compared to other years, which lead to decreased SIC during above years. Also, loss of sea ice during summertime of 2016–2017 in the Antarctic sea ice regions are linked with significant decrease of wind stress magnitude and increase of wind stress curl.