Minisci-type Reactions Research Articles

Alkylations and hydroxymethylations of pyrazines via green Minisci-type reactions.

A new general methodology utilizing Minisci-type chemistry has been developed that cleanly and efficiently prepares alkyl- and (hydroxymethyl)pyrazines. The new methods eliminate toxic catalysts and halogenated solvents, providing a greatly improved route to these natural products which are prevalent in many natural systems as bacterial volatiles, plant volatiles, and insect pheromones.

Pyridazines-XXXIX n-substituted 1,2-dihydro-1,2-diazines formed in homolytic alkoxycarbonylation reactions of pyridazines

Pyridazine and C-alkylpyridazines were found to yield M-ethoxycarbonyl-l,2-dihydropyridazines 1 - 6 when subjected to conditions of homolytic ethoxycarbonylation. This is the first example of an attack of a radical at the nitrogen atom of a N-heteroarene in Minisci-type reactions.