In the process of coal seam mining, there are often hard thick key layers in the overlying strata. Due to the high strength and good integrity of the hard thick key layer, after the hard thick key layer is broken, the overlying strata will collapse and lose stability in a large area, which is very easy to induce dynamic disasters such as rock burst, mine earthquake, coal wall caving, and roof slab caving. Aiming at the hard and thick key layer overlying the working face, the dynamic response of the mine under the strong mine earthquake induced by the breaking of the main key layer of high-level magmatic rock is numerically simulated and analyzed by using FLAC2D numerical simulation software, and the variation laws of the stress field, displacement field, and velocity field of the coal seam roadway under different boundary conditions and different focal heights are studied. The research shows that the roof of solid coal roadway is prone to vibration in a small range, and the displacement increases and decreases with the disturbance. The displacement of the floor and two sides of the solid coal roadway and the top floor and two sides of the roadway along the goaf continues to increase in the initial stage of the disturbance, and the displacement will remain stable with the continuation of the disturbance. The displacement of both sides and roof and floor of gob roadway can reach stability in the later stage of disturbance, and with the increase of the number of adjacent goaf, the longer it takes for the displacement of surrounding rock to reach stability. When the focal height is lower than 90 m, the variation of surrounding rock response increases sharply with the decrease of focal height. When a strong earthquake occurs in the low rock stratum, the impact damage of roadway surrounding rock is almost inevitable. The influence degree of strong earthquake on the stability of roadway surrounding rock is arranged as follows: gob-side roadway (mined out on one side) > solid coal roadway (mined out on both sides) > solid coal roadway (mined out on one side). The evolution process also shows that the working face boundary conditions have an important influence on the energy propagation of mine earthquake. With the increase of the number of adjacent goafs, the faster the energy attenuation rate of mine earthquake propagation is. The research results have important reference significance for the safe mining of working face under similar geological conditions.