PurposeTo ensure the safety of aircraft fuel tanks, the FAA issued an airworthiness clause (25.981(b)) suggesting that the risk of combustion and explosion be reduced by installing a Flammability Reduction Means or an Ignition Mitigation Means. The airflow distribution method has a significant effect on the inerting performance. Therefore, this study aims to determine an optimum airflow distribution method of the inerting system.Design/methodology/approachThis paper establishes the calculation model of the oxygen concentration in the ullage of a multi-bay fuel tank, calculates the oxygen concentration in the ullage of an aircraft tank in single-flow and dual-flow modes under series and parallel ventilation methods and analyses the inerting performance of the tank under different airflow distribution methods.FindingsThe results show that: (1) the bleed flow rate required to achieve whole process inerting of multi-bay fuel tank in dual-flow mode is lower than that in single-flow mode; (2) under the parallel ventilation method, the decrease of oxygen concentration and the uniformity of each bay are better than that in the series ventilation method; (3) dual-flow mode staged ventilation method can be used to achieve the whole process inerting of the tanks under the minimum engine bleed consumption.Originality/valueThe novelty of this paper is to analyze and optimize the airflow distribution method of the inerting system under the whole flight envelope to minimize the engine bleed consumption.