Amelogenesis imperfecta (AI) is a condition that severely affects tooth enamel. In most cases aesthetics and function are compromised while solutions are scarce and have high cost. The purpose of this case report is to describe a rehabilitation case of a 13-year-old male patient diagnosed with amelogenesis imperfecta. A minimally invasive oral rehabilitation was planned using digital workflow for planning, 3D printing of crowns and S-PRG fillers as an aesthetic and functional solution, with lower cost, in the face of the AI case presented. Case report: 13-year-old male with pain, sensitivity, and aesthetics complaints, the patient has been diagnosed with Amelogenesis Imperfecta Hypomaturation-Hypoplastic, Type IV (AIHHT – OMIM: 104510). Treatment was divided into three phases, preventive and sensitivity management, minimally invasive oral rehabilitation – CAD-CAM and orthodontic treatment. It is possible to conclude that digital flow and 3D printing have many benefits for dentistry such as treatment predictability, chairside and lower material waste, cost and working time. It can also be concluded that digital dentistry allows oral rehabilitation following minimal intervention principles and that it was a successful treatment with aesthetic, function and quality of life improvements.