MIMIC Model Research Articles

The Impact and Detection of Uniform Differential Item Functioning for Continuous Item Response Models.

Psychometricians have devoted much research and attention to categorical item responses, leading to the development and widespread use of item response theory for the estimation of model parameters and identification of items that do not perform in the same way for examinees from different population subgroups (e.g., differential item functioning [DIF]). With the increasing use of computer-based measurement, use of items with a continuous response modality is becoming more common. Models for use with these items have been developed and refined in recent years, but less attention has been devoted to investigating DIF for these continuous response models (CRMs). Therefore, the purpose of this simulation study was to compare the performance of three potential methods for assessing DIF for CRMs, including regression, the MIMIC model, and factor invariance testing. Study results revealed that the MIMIC model provided a combination of Type I error control and relatively high power for detecting DIF. Implications of these findings are discussed.

Immunogenicity and protective efficacy of RSV G central conserved domain vaccine with a prefusion nanoparticle

Respiratory syncytial virus (RSV) G glycoprotein has recently reemerged as a vaccine antigen due to its ability to elicit potent neutralizing antibodies and ameliorate disease in animal models. Here we designed three constructs to display the G central conserved domain (Gcc) focused on inducing broad and potent neutralizing antibodies. One construct displaying Gcc from both RSV subgroups trimerized via a C-terminal foldon (Gcc-Foldon) was highly immunogenic in mice and in MIMIC, a pre-immune human in vitro model. To explore an optimal RSV vaccine, we combined the Gcc-Foldon antigen with a stabilized pre-fusion-F nanoparticle (pre-F-NP) as a bivalent vaccine and detected no antigenic interference between the two antigens in the MIMIC model. In RSV-primed macaques, the bivalent vaccine elicited potent humoral responses. Furthermore, both Gcc-Foldon and the bivalent vaccine conferred effective protection against RSV challenge in mice. This two-component vaccine could potentially provide effective protection against RSV infection in humans and warrants further clinical evaluation.

COVID-19 Pandemic and International Students' Mental Health in China: Age, Gender, Chronic Health Condition and Having Infected Relative as Risk Factors.

International students in China were among the first group of individuals to be affected by the COVID-19 pandemic. However, the pandemic’s impact on their mental health is underexplored. This study—utilizing web-based survey data (N = 381), presents preliminary reports using ANOVA and MIMIC analytic approaches. Following the clinical demarcation of the 21-item version of the Depression Anxiety Stress Scales (DASS-21), we found 24.6%, 38.3%, and 43.6% of the students to suffer mild to extreme stress, anxiety, and depression, respectively. Female students reported significantly higher levels of stress and depression than males. Older students’ reports of stress were more substantial than younger students. Students who reported having a relative infected with the virus (vs. those without) experienced significantly higher anxiety and stress. Those who reported having pre-existing chronic health condition(s) (vs. those without) also reported significantly higher stress, anxiety, and depression levels. Moreover, students with an exercise routine (vs. those without) experienced significantly lower levels of stress, anxiety, and depression. Last, our MIMIC model results indicate that foreign students’ age, gender, chronic health status, and having a relative infected with the virus constitute significant risk factors explaining variations in foreign students’ experience of psychological distress. Implications for international students’ management have been thoroughly discussed.

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats.

Simple SummaryAlthough heart failure is a long-term chronic disease, it can also lead to arrhythmia, triggering cardiac arrest, and eventually death. Our study is a randomized and blinded preclinical assessment of the efficacy of the Mn porphyrin compound, MnTnBuOE-2-PyP5+ (BMX-001), commonly known as a superoxide dismutase mimic, in both mouse and rat models of cardiac arrest and resuscitation. Our study indicates that MnTnBuOE-2-PyP5+ improves survival, neurologic function recovery, and behavioral performance in animals suffering from cardiac arrest. The results support the development of Mn Porphyrin-based therapeutics for the treatment of heart failure and cardiac arrest.Introduction Cardiac arrest (CA) and resuscitation induces global cerebral ischemia and reperfusion, causing neurologic deficits or death. Manganese porphyrins, superoxide dismutase mimics, are reportedly able to effectively reduce ischemic injury in brain, kidney, and other tissues. This study evaluates the efficacy of a third generation lipophilic Mn porphyrin, MnTnBuOE-2-PyP5+, Mn(III) ortho meso-tetrakis (N-n-butoxyethylpyridinium-2-yl)porphyrin (MnBuOE, BMX-001), in both mouse and rat models of CA. Methods Forty-eight animals were subjected to 8 min of CA and resuscitated subsequently by chest compression and epinephrine infusion. Vehicle or MnBuOE was given immediately after resuscitation followed by daily subcutaneous injections. Body weight, spontaneous activity, neurologic deficits, rotarod performance, and neuronal death were assessed. Kidney tubular injury was assessed in CA mice. Data were collected by the investigators who were blinded to the treatment groups. Results Vehicle mice had a mortality of 20%, which was reduced by 50% by MnBuOE. All CA mice had body weight loss, spontaneous activity decline, neurologic deficits, and decreased rotarod performance that were significantly improved at three days post MnBuOE daily treatment. MnBuOE treatment reduced cortical neuronal death and kidney tubular injury in mice (p < 0.05) but not hippocampus neuronal death (23% MnBuOE vs. 34% vehicle group, p = 0.49). In rats, they had a better body-weight recovery and increased rotarod latency after MnBuOE treatment when compared to vehicle group (p < 0.01 vs. vehicle). MnBuOE-treated rats had a low percentage of hippocampus neuronal death (39% MnBuOE vs. 49% vehicle group, p = 0.21) and less tubular injury (p < 0.05) relative to vehicle group. Conclusions We demonstrated the ability of MnBuOE to improve post-CA survival, as well as functional outcomes in both mice and rats, which jointly account for the improvement not only of brain function but also of the overall wellbeing of the animals. While MnBuOE bears therapeutic potential for treating CA patients, the females and the animals with comorbidities must be further evaluated before advancing toward clinical trials.

Remediation and detoxification of oil contaminated marine intertidal sites through lipopeptide assisted washing strategy: An experimental and kinetic validation approach

This paper presents a tightly coupled experimental and kinetic approach for efficient remediation of oil spill from contaminated marine intertidal zone surface through a methodical strategy that deals with biosurfactant mediated washing strategy. The study deals with production, optimization and characterization of lipopeptide biosurfactant from Bacillus subtilis T1 and its application in remediation of oil contaminants from mimic model system of various marine intertidal zone i.e. woodland-Group1, saltmarsh-Group2, mangrove-Group3 and mudflats-Group4. Results demonstrates enhanced washing performance with oil desorption rate of 35 % in Group 4, 17.22 %, 15.6 % and 11 % in Group 3, 2 and 1 along with bio surfactant recovery rate of 41 %, 48.7 %, 51.71 % and 50.3 % respectively. Further, the washing strategy was efficient in soil detoxification with highest rate in Group 4. The kinetic validation depicts good match among experimental data and Lagergren pseudo second order data.

Guidelines for inflammation models in mice for food components

AbstractInflammation is one of the major health threats to humans, and it is associated with various chronic diseases, including metabolic syndrome, type 2 diabetes, cardiovascular diseases, and several types of cancer. For example, colonic inflammation can result in the damage of the intestinal barrier, as indicated by invasion of immune cells and reduced tight junctions. Inflammatory responses can also lead to erythema and edema on skin. The intervention of dietary components offers striking possibilities for the prevention of inflammation by modulating the inflammatory signaling pathways and microbiota–inflammation axis. Thus, the preclinical animal models are of critical importance for investigating the anti‐inflammatory effects of food components. This guideline introduces two inflammatory mouse models: dextran sulfate sodium‐induced colonic inflammation and 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced skin inflammation. These mimic models offer the potential to assess food components in attenuating the colonic and skin inflammation in humans.

Connections between Children's Eating Habits, Mental Health, and Parental Stress.

Background Obesity and eating disorders are increasing in occidental countries and can undermine physical and psychological health. Therefore, preventing the insurgency of unhealthy eating habits in childhood is fundamental. Parents can play an important role in assisting pediatricians, psychiatrists, and clinical psychologists in the diagnosis of eating disorders because they have an active role in observing and assessing the quality of their children's eating habits. Methods In our study, we collected data from a sample of children (n = 125) and their parents (n = 161) without symptoms related to eating disorders. Parents assessed the eating habits, behavior problems, and mental health of their children and parental stress. In addition, we measured body mass index, anxiety, and lifestyle in children. Data were analyzed with bivariate correlation and MIMIC models. Results Both mothers' and fathers' assessments of children's eating habits are reliable. Unhealthy eating habits are connected with children's behavioral problems and parental stress. We did not find significant differences in feeding styles and ways of assessing the quality of eating habits between mothers and fathers. Our study showed greater sensitivity of mothers toward the physical fitness of their children rather than fathers. Conclusions Mothers and fathers both proved to be good observers of their children's eating behavior, and they could cooperate with medical and psychological operators in preventing the risk of obesity.

Privacy-preserving mimic models for clinical named entity recognition in French

A vast amount of crucial information about patients resides solely in unstructured clinical narrative notes. There has been a growing interest in clinical Named Entity Recognition (NER) task using deep learning models. Such approaches require sufficient annotated data. However, there is little publicly available annotated corpora in the medical field due to the sensitive nature of the clinical text. In this paper, we tackle this problem by building privacy-preserving shareable models for French clinical Named Entity Recognition using the mimic learning approach to enable the knowledge transfer through a teacher model trained on a private corpus to a student model. This student model could be publicly shared without any access to the original sensitive data. We evaluated three privacy-preserving models using three medical corpora and compared the performance of our models to those of baseline models such as dictionary-based models. An overall macro F-measure of 70.6% could be achieved by a student model trained using silver annotations produced by the teacher model, compared to 85.7% for the original private teacher model. Our results revealed that these privacy-preserving mimic learning models offer a good compromise between performance and data privacy preservation.

Conformational Analysis of Fluoro-, Chloro-, and Proteo-Alkene Gly-Pro and Pro-Pro Isosteres to Mimic Collagen.

Collagen is the most abundant human protein, with the canonical sequence (Gly-Pro-Hyp)n in its triple helix region. Cis-trans isomerization of the Xaa-Pro amide has made two of these amide bonds the target of alkene replacement: the Gly-Pro and the Pro-Hyp positions. The conformations of Gly-Pro and Pro-Pro (as a Pro-Hyp model) fluoro-, chloro-, and proteo-alkene mimic models were investigated computationally to determine whether these alkenes can stabilize the polyproline type II (PPII) conformation of collagen. Second-order Møller-Plesset (MP2) calculations with various basis sets were used to perform the conformational analyses and locate stationary points. The calculation results predict that fluoro- and chloro-alkene mimics of Gly-Pro and Pro-Pro can participate in n→π* donation to stabilize PPII conformations, yet they are poor n→π* acceptors, shifting the global minima away from PPII conformations. For the proteo-alkene mimics, the lack of significant n→π* interactions and unstable PPII-like geometries explains their known destabilization of the triple helix in collagen-like peptides.

The significance of victim ideality in interactions between crime victims and police officers

A crime victim's first contact with the police may strongly influence subsequent investigations and prosecutions, as well as the crime's impact on the victim. The outcomes of such contacts may depend strongly on the degree to which the victim exhibits the characteristics of an ideal victim. This study sought to find valid ways of evaluating the constructs of victim ideality and police empathy, and to clarify the relationship between the two considering background factors, and outcomes. With a cross-sectional design data were collected from approximately 300 crime victims from cities in Colombia using a questionnaire. The data were analyzed using SEM, MIMIC, and logistic regression models. Being an ideal victim was found to influence the empathy displayed by police (as perceived by the victims), which in turn influenced factors important to citizens exposed to crime. Several areas in need of development based on the principles of procedural justice are identified.

The Shadow Economy in Pakistan: An Analysis with MIMIC Model

This paper explicitly presents the estimation of the size and development of the shadow economy. The study examines the impact of multiple exogenous causes (observed variables) on the shadow economy (latent variable) and the size of the shadow economy influencing the performance of multiple macroeconomic indicators. In order to accomplish this econometric analysis, a MIMIC Model (Multiple Indicators Multiple Causes Model) is applied over the period 2011 to 2021. The results indicate that the tax burden, business freedom, unemployment rate, and Gross Domestic Product are the key driving forces of the shadow economy in Pakistan. The findings are potentially beneficial for the policymakers in identifying and dealing with the shadow economic activities as well as developing the strategies relevant to the economic policy.

Telestroke Assessment With Perfusion CT Improves the Diagnostic Accuracy of Stroke vs. Mimic.

Background and Purpose: CT perfusion (CTP) has been implemented widely in regional areas of Australia for telestroke assessment. The aim of this study was to determine if, as part of telestroke assessment, CTP provided added benefit to clinical features in distinguishing between strokes and mimic and between transient ischaemic attack (TIA) and mimic.Methods: We retrospectively analysed 1,513 consecutively recruited patients referred to the Northern New South Wales Telestroke service, where CTP is performed as a part of telestroke assessment. Patients were classified based on the final diagnosis of stroke, TIA, or mimic. Multivariate regression models were used to determine factors that could be used to differentiate between stroke and mimic and between TIA and mimic.Results: There were 693 strokes, 97 TIA, and 259 mimics included in the multivariate regression models. For the stroke vs. mimic model using symptoms only, the area under the curve (AUC) on the receiver operator curve (ROC) was 0.71 (95% CI 0.67–0.75). For the stroke vs. mimic model using the absence of ischaemic lesion on CTP in addition to clinical features, the AUC was 0.90 (95% CI 0.88–0.92). The multivariate regression model for predicting mimic from TIA using symptoms produced an AUC of 0.71 (95% CI 0.65–0.76). The addition of absence of an ischaemic lesion on CTP to clinical features for the TIA vs. mimic model had an AUC of 0.78 (95% CI 0.73–0.83)Conclusions: In the telehealth setting, the absence of an ischaemic lesion on CTP adds to the diagnostic accuracy in distinguishing mimic from stroke, above that from clinical features.

Gender Differences in the Score and Influencing Factors of Social Participation among Chinese Elderly

ABSTRACT This study measured the social participation score of the Chinese elderly, described its decayed trajectory based on birth cohort, and analyzed the gender differences of factors that affected the social participation of the elderly based on MIMIC model by groups. Results showed that age, economic status, and living status were the influencing factors with significant gender differences on social participation level of Chinese elderly. At any age, the social participation of Chinese elderly women was lower than that of elderly men, and this gap widened with age. Social participation of older women was more vulnerable to economic conditions. Living with children had a significant negative impact on the social participation of elderly women. There was no significant gender difference in the influence of marital status and educational level on the social participation of the elderly.

How the shadow economy can be detected in National Accounts

The paper examines how indicators of the shadow economy correspond to the National Accounts values. More precisely, we focus on household accounts assuming that the shadow economy should be visible in the difference between household income and consumption, as household (disposable) income is grossly underreported. Household consumption seems therefore to be a more accurate indicator in this context, as most shadow economy income is eventually spent on consumption. This implies that household savings figures should be negatively related to the values of the shadow economy; consequently, if the values relating to the shadow economy are high, savings should be low, or even negative, and vice versa. We verify this hypothesis using European cross-country data covering the years 1991–2017 with the application of MIMIC model calculations as a point of reference. The estimation results lend very little support to the hypothesis assuming that the shadow economy depresses household savings, even though we can otherwise explain comparatively well the cross-country variation in household savings and consumption growth rates.

Analyzing the effect of supply chain strategies and collaboration on performance improvement using MIMIC model

Analyzing the effect of supply chain strategies and collaboration on performance improvement using MIMIC model

MicroRNA-7188-5p and miR-7235 regulates Multiple sclerosis in an experimental mouse model

The short non-coding microRNAs (miRNAs) have emerged as reliable modulators of various pathological conditions including autoimmune diseases in mammals. The current study, aims to identify new potential differential expressed miRNAs and their downstream mRNA targets of the autoimmune disease, Multiple sclerosis (MS). The study identifies a new set of miRNA(s) that are probably implicated in MS using computational tools. The study further carried-out different in vivo and in vitro experiments to check these identified miRNAs could be role in as therapeutic and prognostic applications. Preliminary insilico screening revealed that miR-659-3p, miR-659-5p, miR-684, miR-3607-3p, miR-3607-5p, miR-3682-3p, miR-3682-5p miR-4647, miR-7188-3p, miR-7188-5p and miR-7235 are specifically elevated in the secondary lymphoid cells of EAE mice. In addition, expression of the downstream target mRNA of these miRNAs such as FXBO33, SGMS-1, ZDHHC-9, GABRA-3, NRXN-2 were reciprocal to miRNA expression in lymphoid cells. These confirmed by applying the mimic and silencing miRNA models, suggesting new inflammatory target genes of these promising miRNA markers. The in vivo adoptive transfer model revealed that the suppression of miRNA-7188-5p and miR-7235 changed the pattern of astrocytes and CNS pathophysiology. The current study opens a new miRNA and their mRNA targets in MS disease. The absence of miRNA-7188-5p and miR-7235 enhanced the disease alleviation, confirms the regulatory effect of these targets. These optimized results highlights new set of miRNA’s with therapeutic potential in experimental MS. Further studies are required to confirm these miRNA as therapeutic biomarker.

Myrmecomorphy in early nymphs of Acontista concinna (Perty) (Mantodea: Acanthopidae: Acontistini), with notes on a new chromatic form

Summary Ant resemblance is common among praying mantis nymphs but switching the model of resemblance across the post-embryonic instars has been previously recorded only for Mantoida maya Saussure & Zehntner and Acontista aurantiaca (Burmeister). This work describes in detail the myrmecomorphy of early nymphs of Acontista concinna (Perty), based on ample material reared from oothecae collected in the field. Mimic models are proposed, and the possible occurrence of transformational mimicry is discussed. The 1st instar nymphs are defended as mimics of Pseudomyrmex gibbinotus (Forel) (Formicidae), but sudden and intense changes in colour and size during the transition to the 2nd instar make them similar to larger ants, namely Camponotus Mayr. This is maintained throughout the 3rd instar, but disappears on the 4th instar, giving place to typical mantid nymphs. A dark brown chromatic form for females of A. concinna is recorded for the first time, and its existence casts further doubts about the value of overall body colour in separating Acontista Saussure & Zehntner from Raptrix Terra.

MIMIC모형에 의한 태권도 수련생의 참가 동기가 수련만족도에 미치는 영향

본 연구에서는 태권도 수련생의 수련만족도를 파악하기 위해 참가 동기를 원인으로 심리 사회적 특성을 파악하여 만족도를 향상 시킬 수 있는 전략적 방안을 강구 하는데 궁극적인 목적이 있다. 조사대상은 충청도 소재 태권도장 초, 중등부 수련생을 대상으로 최총 318명의 설문지를 연구목적에 따라 분석하였다. 조사 도구는 참가 동기(양명환, 2000)와 수련만족도(남승우, 1997; 양현석, 1999; 오대영, 1995; 윤아영, 2012; 윤오남, 2002) 이며 5점 Likert 척도를 사용하여 였고, 기술통계와 mimic형 구조 방정식 모형분석을 SPSS 23과 Amos 23 버전을 사용하여 분석하였다. 결과는 다음과 같다. 첫째, 연구가설Ⅰ인 참가 동기는 신체적 만족에 영향을 미쳤다. 구체적으로 참가 동기에 학습 동기가 가장 높게 영향을 미치는 가운데 신체적 만족에 영향을 미쳤다. 둘째, 연구가설Ⅱ인 참가 동기는 정신적 만족에 영향을 미쳤다. 구체적으로 참가 동기에 학습 동기가 가장 높게 영향을 미치는 가운데 정신적 만족에 영향을 미쳤다. 셋째, 연구가설Ⅲ인 참가 동기는 기술습득 만족에 영향을 미쳤다. 구체적으로 참가 동기에 학습 동기가 가장 높게 영향을 미치는 가운데 기술습득 만족에 영향을 미쳤다. 넷째, 연구가설Ⅳ인 참가 동기는 자아방어 만족에 영향을 미쳤다. 구체적으로 참가 동기에 학습 동기가 가장 높게 영향을 미치는 가운데 자아 방어 만족에 영향을 미쳤다.

Catalytic, theoretical, and biological investigation of an enzyme mimic model.

Artificial catalyst studies were always stayed at the kinetics investigation level, in this work bioactivity of designed catalyst were shown by the induction of biomineralization of the cells, indicating the possible use of enzyme mimics for biological applications. The development of artificial enzymes is a continuous quest for the development of tailored catalysts with improved activity and stability. Understanding the catalytic mechanism is a replaceable step for catalytic studies and artificial enzyme mimics provide an alternative way for catalysis and a better understanding of catalytic pathways at the same time. Here we designed an artificial catalyst model by decorating peptide nanofibers with a covalently conjugated catalytic triad sequence. Owing to the self-assembling nature of the peptide amphiphiles, multiple action units can be presented on the surface for enhanced catalytic performance. The designed catalyst has shown an enzyme-like kinetics profile with a significant substrate affinity. The cooperative action in between catalytic triad amino acids has shown improved catalytic activity in comparison to only the histidine-containing control group. Histidine is an irreplaceable contributor to catalytic action and this is an additional reason for control group selection. This new method based on the self-assembly of covalently conjugated action units offers a new platform for enzyme investigations and their further applications. Artificial catalyst studies always stayed at the kinetics investigation level, in this work bioactivity of the designed catalyst was shown by the induction of biomineralization of the cells, indicating the possible use of enzyme mimics for biological applications.

The Role the Informal Economy Plays on Entrepreneurship with an Emphasis on Institutional Quality Index

The informal economy is one of the most important influencing factors on the type of entrepreneurial activity. In this study, the role of the informal economy on the formation of entrepreneurial activities (opportunity and necessity-based entrepreneurship) with an emphasis on the institutional quality index in selected oil producing countries during the period 2018–2008 has been investigated. This was done by using the three stage least squares model. In addition, the MIMIC model was used to extract the hidden variable of the informal economy volume and the principal components. Furthermore, the analysis model was used to extract the institutional quality index.The results show that increasing unemployment, increasing tax rates and increasing natural resource rent lead to an increase in the informal economy in these countries, whereas an increase in the informal economy leads to a decrease in opportunity-based entrepreneurship and increases necessity-based entrepreneurship. These results suggest that if the goal is to improve opportunity-based entrepreneurship, macroeconomic policies should be designed to reduce unemployment and lower tax rates and natural resources rent, thereby reducing the size of the informal economy in these countries. In such circumstances, an increase in opportunistic entrepreneurship is possible and an improvement in the economic growth of this field can be expected.