The study aimed to analyze how milling time (2 h-24 h) affects structural, mechanical, and tribological properties of Ti-15Mo alloys, these last has evaluated by using XRD, SEM, and a ball-on-disk tribometer. The wear tests were carried out under applied, loads of 2, 8 and 16 N respectively. Results revealed that crystallite size decreased to, 25.5 nm, while lattice parameter increased to 5.34 Å, and porosity reduced to 0.07%, Conversely, mean pore size decreased to 31 nm after 24 h. Moreover, relative density, and Young's modulus increased with prolonged milling. Coefficient of friction, wear, volume, and rate increased with applied load (2–16 N) but decreased with milling time, especially in binary titanium alloys under 16 N load. Optimal conditions were identified, at 24 h milling and 16 N load