The primary objectives of the current investigation were to design and characterize enteric-coated oil of ginger tablets in coconut water powdered form as a therapy for ulcerative colitis. One source that is both anti-inflammatory and high in electrolytes is a combination of ginger oil and powdered coconut water. By reducing inflammation and improving electrolyte and water balance, this combination will hasten the healing process. Starch 1500, microcrystalline cellulose, and ethyl cellulose were used to create enteric-coated tablets of ginger oil alone and in combination with coconut water powder. The results corroborated the findings that there were no unique interactions between any of the substances, as demonstrated by the examination of both tablets, which included morphology, micrometric features, and fourier transform infrared (FTIR) spectroscopic capabilities. We studied the dissolving characteristics of coated tablets at pH 1.2, 6.8, and 7.4 in a buffer. Quantification of gingerol was accomplished by use of reverse-phase high-performance liquid chromatography (RP-HPLC) technology. The selected formulation’s therapeutic efficacy was lastly confirmed using a colitis model generated by 2,4,6-trinitrobenzene sulfonic acid. Tablets containing either ginger oil or a powdered combination of ginger oil as well as coconut water were compared in the research. Myeloperoxidase, lipid peroxidase, and histological assessment were calculated using the colitis model. The colon/body weight ratio was also measured. Research on animals has shown that a combination of the coated oil of ginger and the oil of coconut tablets, as opposed to ginger oil tablets alone, considerably improved the sick conditions in Wistar rats. The gain in weight and clinical improvements in the macroscopic and microscopic factors of induced colitis served as evidence of this. These results demonstrate the potential of coated tablets formulated with coconut water powder for the targeted delivery of ginger oil to the colon as well as for the improvement of colon health through the balance of micronutrients and water content. It is not practical to increase the dosage to compensate for metabolic loss while using ginger oil because of its strong taste and strength. Therefore, the formulation of choice is enteric coating. As enteric coating tablets target the intestine as the site of action, it is possible to use less potent ginger oil. Due to the inclusion of coconut water powder, the formulation not only helps cure the illness state but also promotes and supports a speedy recovery.