As nanotechnology is expanding its application in engineering science, it provides ample opportunities to explore fluid properties with the help of nanoparticles for growing significance in different industries. Heat and energy management are the major concerned areas to the industries as well as researchers. This article carried out the investigation of gyrotactic microorganisms incorporated in Casson nanofluid, with activation energy, Hall, Joule heating, and other parameters. The major interest of this article was to explore the characteristic of the bioconvective magneto Casson nanofluid by analyzing the influence of the key parameters on the heat, flow, concentration and microbial concentration profiles. Thepreliminary borderline circumstances with prevailing partial differential equations by use of appropriate similarity variations were rewritten as ordinary differential equations (ODEs) and ultimate borderline environments correspondingly. Furthermore, we used the Spectral Quasi-Linearization (SQLM) method for the numerical calculation of ODEs to get the consequences of the key parameters. Analysis of the flow in both directions i.e. the tangential and circumferential, temperature, solutal, and microbial distribution with activation energy, and the ion-slip, Hall current, and other interesting parameters was done by their pictorial views. The quantities of physical attention were examined and reflected the flattering outcomes. The increasing Casson nanofluid parameter reduces the velocity outline of the flow while expanding the temperature outline, on the other side the microbial, and solutal profiles was enriched by the rising values of the activation energy constraint. The rising of temperature profile has been observed for the increasing values of the thermal radiation as well as buoyancy ratio parameters. The effect of different parameters on engineering interest quantities was also considered. The growing Casson fluid parameter, minimize the local Nusselt number approximately 43%, while the quantities of local Sherwood and local density of microbial increase by approximately 16% and 22%, correspondingly. The local Nusselt number decreases about 87%, however, the local quantities of Sherwood, and density of microbial increase by about 13% and 12%, respectively for increasing values of thermal radiation.