Event Abstract Back to Event TOLL-LIKE RECEPTOR 2, 4 AND 9 GENETIC VARIANTS IN MEXICAN PATIENTS WITH AMOEBIC LIVER ABSCESS Oswaldo Partida-Rodriguez1, Eric Hernandez1, Carmen Maldonado2, Miriam Nieves-Ramirez1, Olivia Valenzuela3, Ulises Magaña3, Edgar Rascon3, Valeria Zermeño1, Tobias Portillo1, Liliana Rojas1, Rene Cerritos1, Alicia Valadez1, Enrique Gonzalez1, Patricia Moran1 and Cecilia Ximenez1* 1 National Autonomous University of Mexico, Department of experimental Medicine, Mexico 2 Children's Hospital of Mexico Federico Gomez (HIM), Laboratory of Hematology, Mexico 3 University of Sonora (UNISON), Department of Chemistry and Biological Sciences, Mexico Toll-Like Receptors (TLRs) recognize Entamoeba histolytica molecular patterns generating a series of intracellular signaling that leads to the modulation of the innate immune system. Single nucleotide polymorphisms (SNPs) in TLR genes may influence their activity. We studied associations of TLRs SNPs with susceptibility to develop amoebic liver abscess (ALA) by Entamoeba histolytica in Mexican individuals from the State of Sonora and from Mexico City (DF). We typed by allelic exclusion the SNPs R677W and R753Q of TLR2, D299G and T399I of TLR4, and -1237T/C and 2848G/A of TLR9. We compared SNPs frequencies of ALA patients (Sonora n=32, DF n=32) with control individuals (Sonora n=58, DF n=21). The genotype TLR9 2848G/A in ALA patients from DF showed a statistically (p=0.008) increased frequency (63.3%) when compared with controls (25.0%), with an OR of 5.18 (95% CI 1.27-22.37). We will increase sample size in order to find out if the TLR9 2848G/A can be considered as a marker of susceptibility to ALA in population from the center of Mexico. Acknowledgements Work partially supported by PAPIIT IN206408, IN206405, PAPIME 200105 and SEP-CONACYT 79220. Keywords: TLRs (Toll-like receptors), Polymorphism, Single Nucleotide, Entamoeba histolytica, Amoebic liver abscess, Immunogenetics Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune receptors and signaling Citation: Partida-Rodriguez O, Hernandez E, Maldonado C, Nieves-Ramirez M, Valenzuela O, Magaña U, Rascon E, Zermeño V, Portillo T, Rojas L, Cerritos R, Valadez A, Gonzalez E, Moran P and Ximenez C (2013). TOLL-LIKE RECEPTOR 2, 4 AND 9 GENETIC VARIANTS IN MEXICAN PATIENTS WITH AMOEBIC LIVER ABSCESS. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00769 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Jun 2013; Published Online: 22 Aug 2013. * Correspondence: Prof. Cecilia Ximenez, National Autonomous University of Mexico, Department of experimental Medicine, Mexico City, Mexico, cximenez@servidor.unam.mx Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Oswaldo Partida-Rodriguez Eric Hernandez Carmen Maldonado Miriam Nieves-Ramirez Olivia Valenzuela Ulises Magaña Edgar Rascon Valeria Zermeño Tobias Portillo Liliana Rojas Rene Cerritos Alicia Valadez Enrique Gonzalez Patricia Moran Cecilia Ximenez Google Oswaldo Partida-Rodriguez Eric Hernandez Carmen Maldonado Miriam Nieves-Ramirez Olivia Valenzuela Ulises Magaña Edgar Rascon Valeria Zermeño Tobias Portillo Liliana Rojas Rene Cerritos Alicia Valadez Enrique Gonzalez Patricia Moran Cecilia Ximenez Google Scholar Oswaldo Partida-Rodriguez Eric Hernandez Carmen Maldonado Miriam Nieves-Ramirez Olivia Valenzuela Ulises Magaña Edgar Rascon Valeria Zermeño Tobias Portillo Liliana Rojas Rene Cerritos Alicia Valadez Enrique Gonzalez Patricia Moran Cecilia Ximenez PubMed Oswaldo Partida-Rodriguez Eric Hernandez Carmen Maldonado Miriam Nieves-Ramirez Olivia Valenzuela Ulises Magaña Edgar Rascon Valeria Zermeño Tobias Portillo Liliana Rojas Rene Cerritos Alicia Valadez Enrique Gonzalez Patricia Moran Cecilia Ximenez Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.