Methyl Ester Administration Research Articles

Administration of prostaglandins by various routes for induction of abortion merits and demerits

Prostaglandin F2alpha and its methyl analogues were used for induction of abortion in 598 patients with gestational age from 9 to 20 weeks. Different routes of administration were studied and various dosages given. The incidence of gastrointestinal side effects were within acceptable range for all methods. Both intra-amniotic injections of 50 mg PGF2alpha and 2.5 mg 15-methyl PGF2alpha as well as intramuscular and vaginal administration of 15-methyl PGF2alpha or its methyl ester, respectively, were highly effective in termination of pregnancy. The intramuscular route was, however, associated with the highest frequency of gastrointestinal side effects. If both efficacy and side effects were taken into consideration, the intra-amniotic and vaginal routes were superior. The ease of administration as well as the applicability over a wider range of gestation in termination of pregnancy may, however, in many situations speak in favour of the repeated vaginal administration of 15-methyl PGF2alpha methyl ester.

Repeated vaginal administration of 15-methyl PGF 2α methyl ester for termination of pregnancy in the 13th–20th week of gestation

Abstract In a comparative multicentre trial, vaginal suppositories containing 1.5 mg 15-methyl prostaglandin F 2α methyl ester were administered at 3-hour intervals to 310 patients. Abortion of the fetus occurred within 24 hours in 274 patients (88.4%) and within 30 hours in 285 patients (91.9%). The mean induction-abortion interval was 14.2 hours. Abortion was complete in 49.9 per cent of the cases. The most common side effects were vomiting and diarrhoea. The mean frequency of vomiting and diarrhoea was 2.8 episodes per patient for both types of side effects, while temperature elevation above 38 °C occurred in 11.7 per cent of the cases. Repeated vaginal administration of 15-methyl PGF 2α methyl ester is an effective, noninvasive method for termination of second trimester pregnancy. Further development of suppositories should achieve a longer action combined with a decrease in gastrointestinal side effects.

Mitosis in the ascites tumor in the rat after administration of trimethylcolchicinic acid methyl ester alone or in combination with phlorhizin

The mitoses blocking in rat ascite tumours has been studied after administration of different doses of d-tartrate of trimethylcolchicinic acid methyl ester (NCI 1136). The number of mitoses gradually increases until the 7th hour. Then a diminution is observed for the smallest doses, while it is unmodified for the mean doses and increases again for the large and small doses repeated. The association of Florizine prolonges and enhances the mitotic blocking. The modifications induced by NCI 1136 are repaired between the 24th and 72nd hour after injection: the smallest the dose administered, the most precocious the reparation. The capacity of NCI 1136 to prolonge the life of the tumour bearing animal is discussed and its action on mitoses is compared to that obtained with colchicine.

Biotin and Scaly Dermatosis of the Chick

ConclusionBiotin-deficiency is brought about in the chick reared on a heated ration of low biotin content (O.1γ/g). This deficiency is produced in the absence of dietary egg white which is essential for the development of the avitaminosis in the rat. Deficiency symptoms are completely cured by administration of crystalline biotin methyl ester. The chick can be used in a quantitative biological assay of biotin.