The article reveals the tactical and forensic features of interrogation in criminal proceedings in the conditions of the existence of a conflict situation at the stage of pre-trial investigation. The author’s recommendations regarding the sequence of presentation of physical evidence of a material nature to a suspect in the commission of a criminal offense and the subsequent selection of testimony about the circumstances of the commission of the offense are submitted for consideration and discussion in general. Also, the tactical-forensic methods of interrogation previously worked out and already formed by criminologists-practitioners are considered. Modern (innovative) procedural rules and tactical interrogation techniques are being developed, taking into account the variable position of the suspect: sincere confession and denial of his participation in the committed criminal offense. The authors of the article state and outline the legal aspects regarding the legality of using forensic and procedural methods of obtaining and collecting the evidence base. The meaning is revealed and an assessment is made of these novels and the latest approaches in implementing the tasks of the Criminal and Criminal Procedure Codes of Ukraine regarding the protection of individuals, society, and the state from criminal offenses, protection of the rights, freedoms and legitimate interests of participants in criminal proceedings, as well as in the legal provision of protection of public safety and of the constitutional system of Ukraine from criminal and illegal encroachments, thereby ensuring the peace and security of mankind. The need for further research in the appropriate direction is substantiated, as the latter will create prospects for theoretical and practical studies and contribute to solving problematic issues in procedural law and criminology. Attention was drawn to the need for further cooperation between scientists and practitioners in the field of material and procedural law, namely: criminal law, process, and criminology.