Metastasis Of Tongue Cancer Research Articles

両側頚部郭清術後のＭＲＳＡ腸炎例

The number of patients with postoperative enterocolitis caused by MRSA has been rapidly increasing since the use of antibiotic prophylaxis consisting of extended-spectrum cephems. We encountered a case of postoperative enterocolitis due to MRSA. The patient was an 26-year-old female who had bilateral cervical lymph node metastasis of tongue cancer; the enterocolitis appearred after we performed bilateral neck dissection. We used prophylactic antibiotics (FMOX) following the operation to prevent infection. Abdominal pain, high fever, and white watery diarrhea appeared seven days after the operation. MRSA was detected in her feces. Toxic shock syndrome toxin I (TSST-I) was induced by this MRSA. The patient was treated with oral vancomycin (2g/day), to which this MRSA showed sensitivity. The patient showed improvement in her symptoms, serum CRP level, and, leucocytosis after 12 days.

舌癌のリンパ節転移を疑った耳下腺下極の腺リンパ腫の２症例

舌癌のリンパ節転移を疑った耳下腺下極の腺リンパ腫の２症例

Second Place — Resident Clinical Science Award 1994: Tumor Angiogenesis, the P53 Antigen, and Cervical Metastasis in Squamous Cell Carcinoma of the Tongue

A more accurate method of detecting nodal disease in squamous cell carcinoma of the tongue is needed so that treatment of the neck with its associated morbidity can safely be reserved for patients who actually have metastatic disease. Tumor angiogenesis and the expression of the p53 antigen--which have each been shown to be predictive of metastasis in breast and colon cancer, respectively--are examined for their ability to predict neck metastasis in tongue cancer. Fifty-seven patients with T1 and T2 squamous cell carcinoma of the oral tongue, whose neck disease was examined by dissection or by 2-year follow-up, were studied. Twenty-eight patients (49%) were node positive and 29 patients (51%) were node negative. The primary tumors were immunohistochemically stained for the p53 antigen and for factor VIII, which allowed the blood vessels within the tumor to be quantitated. The mean vessel counts per x200 high-power field were 59.8 and 61.5 for node-positive and node-negative patients, respectively (p = 0.8). Node-positive patients showed overexpression of p53 43% of the time, vs. 61% for node-negative patients (p = 0.17). Multivariate analysis confirmed that no difference in tumor angiogenesis or the expression of the p53 antigen was found between tumors that had metastasized and those that had not. Therefore neither tumor angiogenesis nor the p53 tumor marker is clinically useful in determining lymph node metastasis in these patients.

A clinical evaluation of preventive radiotherapy for the neck metastasis of tongue cancer

Forty patients of Tx No squamous cell carcinoma of mobile tongue were treated at Kobe University, Departments of Otolaryngology and Radiology between November 1975 and October 1980. Twenty-three patients had preventive neck irradiation prior to the local treatment. Six of these patients subsequently developed a neck nodal metastasis. The primary lesion was uncontrolled in 4 of these 23 cases.Eight of the 17 without neck irradiation subsequently developed a neck nodal metastasis within 1 year and the primary lesion was uncontrolled in 7 of these 17 cases. The rate of lymph node metastasis in T1 and T2 patients with neck irradiation was significantly lower than that in those without neck irradiation. Post-irradiation necrosis of the mandible occurred in 3 of the 23 patients with preventive irradiation. We consider that the preventive neck irradiation for the patients with T1 and T2, No tongue cancer is effective in destroying subclinical metastasis and the mandible should not be included in the irradiation field.