Metal Nanoparticles Research Articles

Promotion of Probabilistic Bit Generation in Mott Devices by Embedded Metal Nanoparticles.

Considerable attention has been drawn to the use of volatile two-terminal devices relying on the Mott transition for the stochastic generation of probabilistic bits (p-bits) in emerging probabilistic computing. To improve randomness and endurance of bit streams provided by these devices, delicate control of the transient evolution of switchable domains is required to enhance stochastic p-bit generation. Herein, we demonstrate that the randomness of p-bit streams generated via the consecutive pulse inputs of pump-probe protocols can be increased by the deliberate incorporation of metal nanoparticles (NPs), which influence the transient dynamics of the nanoscale metallic phase in VO2 Mott switches. Among the vertically stacked Pt-NP-containing VO2 threshold switches, those with higher Pt NP density show a considerably wider range of p-bit operation (e.g., up to ∼300% increase in ΔVprobe upon going from (Pt NP/VO2)0 to (Pt NP/VO2)11) and can therefore be operated under the conditions of high speed (400 kbit/s), low power consumption (14 nJ/bit), and high stability (>105,200 bits) for p-bit generation. Thus, our study presents a novel strategy that exploits nanoscale phase control to maximize the generation of nondeterministic information sources for energy-efficient probabilistic computing hardware. This article is protected by copyright. All rights reserved.

Silver Nanoparticle-Embedded Carbon Nitride: Antifungal Activity on Candida albicans and Toxicity toward Animal Cells.

The development of engineered nanomaterials has been considered a promising strategy to control oral infections. In this study, silver-embedded carbon nitrides (Ag@g-CN) were synthesized and tested against Candida albicans, investigating their antifungal action and biocompatibility in animal cells. Ag@g-CN was synthesized by a simple one-pot thermal polymerization technique and characterized by various analytical techniques. X-ray diffraction (XRD) analysis revealed slight alterations in the crystal structure of g-CN upon the incorporation of Ag. Fourier transform infrared (FT-IR) spectroscopy confirmed the presence of Ag-N bonds, indicating successful silver incorporation and potential interactions with g-CN's amino groups. UV-vis spectroscopy demonstrated a red shift in the absorption edge of Ag@g-CN compared with g-CN, attributed to the surface plasmon resonance effect of silver nanoparticles. Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) confirmed the 2D layered sheet like morphology of both materials. The Ag 3d peaks found in X-ray photoelectron spectroscopy (XPS) confirmed the presence of metallic Ag0 nanoparticles in Ag@g-CN. The Ag@g-CN materials exhibited high antifungal activity against reference and oral clinical strains of C. albicans, with minimal inhibitory concentration (MIC) ranges between 16-256 μg/mL. The mechanism of Ag@g-CN on C. albicans was attributed to the disruption of the membrane integrity and disturbance of the biofilm. In addition, the Ag@g-CN material showed good biocompatibility in the fibroblastic cell line and in Galleria mellonella, with no apparent cytotoxicity observed at a concentration up to 1000 μg/mL. These findings demonstrate the potential of the Ag@g-CN material as an effective and safe antifungal agent for the treatment of oral fungal infections.

Light as an Orthogonal Synthetic Parameter in Metal Nanoparticle Growth

Light as an Orthogonal Synthetic Parameter in Metal Nanoparticle Growth

Comparative Investigation of Thermal Properties Improvement of Nano-Enhanced Organic Phase Change Materials

Thermal energy storage (TES) using phase change materials (PCMs) is one of the potential solutions for stockpiling thermal energy and utilizing it for different applications, which results in effective energy usage. The main drawback of organic PCMs in practical applications is poor heat transfer due to low thermal conductivity (TC). Therefore, investigations into nano-enhanced PCMs are being explored to improve their thermophysical properties. In this work, the various thermophysical characteristics of nano-enhanced lauryl alcohol as a PCM were investigated using carbon-based and metallic nanoparticles. The results indicated that the addition of nanoparticles improved its thermal properties and affected other physical properties, such as viscosity. The latent heat was degraded with the addition of nanoparticles. The results revealed that by adding MWCNTs and CuO nanoparticles, a maximum of 82.6% and 49.6% improvement in TC was achieved, respectively. The maximum drop in latent heat during melting and freezing for the PCM with MWCNTs was about 10.1% and 9.3%, respectively, whereas for the PCM with CuO, they were about 11% and 10.3%, respectively. The lowest supercooling for the PCM with MWCNTs and CuO nanoparticles was 8.6 and 8.3 °C, respectively. The present work confirms that nano-enhanced PCMs can be a potential material for storing thermal energy for various applications.

HER2 siRNA Facilitated Gene Silencing Coupled with Doxorubicin Delivery: A Dual Responsive Nanoplatform Abrogates Breast Cancer.

The present study investigated the concurrent delivery of antineoplastic drug, doxorubicin, and HER2 siRNA through a targeted theranostic metallic gold nanoparticle designed using polysaccharide, PSP001. The as-synthesized HsiRNA@PGD NPs were characterized in terms of structural, functional, physicochemical, and biological properties. HsiRNA@PGD NPs exposed adequate hydrodynamic size, considerable ζ potential, and excellent drug/siRNA loading and encapsulation efficiency. Meticulous exploration of the biocompatible dual-targeted nanoconjugate exhibited an appealing biocompatibility and pH-sensitive cargo release kinetics, indicating its safety for use in clinics. HsiRNA@PGD NPs deciphered competent cancer cell internalization, enhanced cytotoxicity mediated via the induction of apoptosis, and excellent downregulation of the overexpressing target HER2 gene. Further in vivo explorations in the SKBR3 xenograft breast tumor model revealed the appealing tumor reduction properties, selective accumulation in the tumor site followed by significant suppression of the HER2 gene which contributed to the exclusive abrogation of breast tumor mass by the HsiRNA@PGD NPs. Compared to free drugs or the monotherapy constructs, the dual delivery approach produced a synergistic suppression of breast tumors both in vitro and in vivo. Hence the drawings from these findings implicate that the as-synthesized HsiRNA@PGD NPs could offer a promising platform for chemo-RNAi combinational breast cancer therapy.

Nanoparticles for the treatment of spinal cord injury

Abstract Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

The role of Au and Pd in photocatalytic activation of molecular oxygen: A mechanistic study

Activation of molecular oxygen plays an important role in photocatalytic selective oxidation reactions and complete degradation of organic pollutants. Noble metal cocatalysts are often employed to modulate the activation of oxygen to reach an optimum photocatalytic performance. However, the role of the metal nanoparticles (NPs) still remains unclear and deserves investigation for the design of efficient photocatalysts. Here, Au and Pd NPs are deposited on the TiO2 photocatalyst to study the promotional mechanism of O2 dissociation with the presence of glycerol under irradiation by near-ambient-pressure photoelectron spectroscopy and in-situ spectrometry approaches. While both Au and Pd NPs can dissociate O2 into activated oxygen species, a relatively strong bonds of dissociated oxygen atom is observed on Au NPs than on the Pd NPs. This results in a moderate reduction rate of O2 and eventually favors a mild oxidation reaction process for Au, and a rapid reduction rate of O2 and eventually a deep oxidation reaction process for Pd, respectively.

GOLD PLASMONIC ARRAY STRUCTURES FOR SENSING APPLICATIONS

This article is devoted to the theoretical study of the plasmonic properties of periodically arranged arrays of gold nanoparticles. The Comsol Multiphysics software, which is based on the finite element method, was used to build 3D numerical models for the simulation and conduct research. In this work the electric field distribution and optical characteristics of the spherical gold nanoparticles array were studied. Individual localized surface plasmon resonance modes are influenced when metallic nanoparticles are in the close proximity and as a result the electric near- fields can couple, resulting in a new hybrid mode. We mainly focused here on the investigation of two crucial questions, particularly, influences of the gap between the nanoparticles and the refractive index of the surrounding medium on the resulting optical response of the gold nanoparticles arrays. The array of periodically arragement gold nanoparticles is characterized by an enhanced local electric field between the nanoparticles, which is inversely proportional to the gap between the particles. The field strength and optical properties (reflection, transmission, and absorption) can be conveniently manipulated by changing the gap between particles. In additional, their potential applications as sensetive plasmonic sensors element have been considered. The studied structure has a significant potential for practical applications due to its wide range of the operating wavelengths and ease of the high-throughput fabrication. In the course of the study, it was established that the change in the distance between the surface of nanoparticles by 1 nm leads to a significant shift in the spectral transmission and reflection curves on the spectral range. In addition, these studies showed that an increase in the distance between the surfaces of nanoparticles leads to the decrease in the near-field interaction between gold nanoparticles in the array. Therefore, the obtained results can be successfully used in the manufacture of highly sensitive plasmon sensors with the possibility of controlling the sensitivity and the working spectral range.

Direct Synthesis of Calcium Lactate through the Reaction of Glycerol with Calcium Hydroxide Catalyzed by Bimetallic AuCu/SiO2 Nanocatalysts

Bimetallic AuCu/SiO2 nanosized catalysts were prepared using the wet chemical reduction technique. From among Au0.1–1.5Cu10/SiO2 catalysts, the Au0.5Cu10/SiO2 catalyst gave the highest yield of calcium lactate of 87% at a glycerol conversion of 96% when the reaction of glycerol with calcium hydroxide at a mole ratio of calcium hydroxide to glycerol of 0.8:1 was conducted under an anaerobic atmosphere at 200 °C for 2 h. The interactions between metallic Au0 and Cu0 nanoparticles facilitate calcium lactate formation. The simulation of glycerol consumption rate with an empirical power-function reaction kinetics equation yielded a reaction activation energy of 44.3 kJ∙mol−1, revealing that the catalytic reaction of glycerol with calcium hydroxide to calcium lactate can be conducted by overcoming a mild energy barrier. The synthesis of calcium lactate through the catalytic reaction of glycerol with calcium hydroxide on a bimetallic AuCu/SiO2 nanosized catalyst under a safe anaerobic atmosphere is an alternative to the conventional calcium lactate production technique through the reaction of expensive lactic acid with calcium hydroxide.

A Review on Metallic Nanoparticles

Metallic nano-particles are nano scale metals that fall between one to one hundred nano meters in length, breadth, and thickness. Faraday looked into the possibility of metallic nanoparticles in solution for the first time in 1856. These days, it is possible to create and modify these nanomaterials with different chemical functional groups, enabling them to engage with medicines, ligands, and antibodies. Applications for metallic nanoparticles in biotechnology, therapeutics, and medication and gene delivery are numerous. The features, benefits, drawbacks, and attributes of metal nanomaterials are outlined in this review. This review also highlights how metallic nanomaterials work as catalysts, which is necessary for stabilization. It provides the readers with detailed information on the synthesis by various methods and characterization, with a particular focus on therapeutic application along with potential side effects and their future perspectives. Recent headway has opened the way to site-specific targeting and drug delivery by these metallic nano particles. Keywords: Surface Atom and Quantum Dot, Metal Nano particle, Gold, Platinum, and Silver Nano particle, Catalyst.

A comparative study of single and dual sintering processes of metal nanoparticles for flexible electronics application

The introduction of metallic nanoparticles (NPs) has revolutionized the fabrication of flexible electronic devices. Metallic NPs have numerous applications in the electronics industry due to their unique shape and size‐dependent properties compared to their bulk counterparts. However, the application of metallic NPs requires additional post‐processing procedures to remove stabilizing agents and additives, to achieve superior electrical conductivity. In this study, the sintering of printed metal NP patterns, including silver (Ag) and copper (Cu) NPs, fabricated on flexible polyimide substrates is explored using single and dual sintering methods. The single sintering methods involve exposing the printed metal NPs to either laser irradiation or thermal treatment. In the case of the dual sintering methods, one approach is to subject the printed metal patterns to thermal treatment followed by laser irradiation, while the other approach involves exposing the printed metal patterns to laser irradiation followed by thermal treatment. Moreover, this study identifies and compares the effects of these various sintering methods on the physical, electrical, chemical, and mechanical properties of the Ag and Cu NP patterns. Finally, the study suggests that dual sintering methods are more effective in improving the electrical conductivity and mechanical properties of the NP patterns under optimized sintering conditions.This article is protected by copyright. All rights reserved.

Green and chemical syntheses of silver nanoparticles: Comparative and comprehensive study on characterization, therapeutic potential, and cytotoxicity

The emergence of metallic nanoparticles through green synthesis has garnered significant recognition, shaping global research efforts towards eco-friendly practices, often termed as the green revolution. Specifically, the green synthesis of silver nanoparticles (AgNPs) has made considerable strides in the past decade, becoming a prominent fixture in the realm of science and technology. The study explores the synthesis and characterization of silver nanoparticles (AgNPs) using Cassia fistula L. flowers extract through chemical co-precipitation (CM_AgNPs) and green methods (CFF_AgNPs). Characterization techniques, including scanning electron microscopy (SEM), transmission electron microscopy (TEM), attenuated total reflectance fourier-transform infrared (FTIR), and X-ray diffraction (XRD), revealed irregular morphologies with agglomeration, polycrystalline nature, and intrinsic functional groups involved in capping AgNPs. Antioxidant assessment demonstrated superior antioxidative activity (84.48 %) in green-synthesized nanoparticles compared to chemically synthesized ones (75.87 %), and they exhibited dose-dependent anti-inflammatory effects with IC50 values CFF_AgNPs_30.19 μg/mL and CM_AgNPs _34.14 μg/mL respectively. The lower IC50 value of CFF_AgNPs_30.19 μg/mL signifies finer and better activity due to the presence of phytochemicals present in it. Whereas for CM_AgNPs the IC50 value is a 34.14 μg/mL which is solely due to AgNPs. To ensure the promising therapeutic aspects of AgNPs with a careful assessment of their safety profile, cytotoxicity of AgNPs on HEP3B cancer cells was evaluated through MTT assay, lactate dehydrogenase (LDH) release, and reactive oxygen species (ROS) level measurement. In the in vitro cytotoxicity evaluation, HEP3B demonstrated more pronounced dose-dependent adverse effects upon exposure to CFF_AgNPs compared to CM_AgNPs. This study underscores the bioactive potential of Cassia fistula L. mediated AgNPs, suggesting promising applications in biomedicine with environmental sustainability. The findings contribute to the growing interest in green synthesis methods for metallic nanoparticles and their potential benefits in various fields.

Mixture toxicity study of two metal oxide nanoparticles and chlorpyrifos on Eisenia andrei earthworms.

Co-exposure soil studies of pollutants are necessary for an appropriate ecological risk assessment. Here, we examined the effects of two-component mixtures of metal oxide nanoparticles (ZnO NPs or goethite NPs) with the insecticide chlorpyrifos (CPF) under laboratory conditions in short-term artificial soil assays using Eisenia andrei earthworms. We characterized NPs and their mixtures by scanning electron microscopy, atomic force microscopy,dynamic light scattering and zeta potential, and evaluated effects on metal accumulation, oxidative stress enzymes, and neurotoxicity related biomarkers in single and combined toxicity assays. Exposure to ZnO NPs increased Zn levels compared to control in single and combined exposure (ZnO NPs + CPF) at 72h and 7days, respectively. In contrast, there was no indication of Fe increase in organisms exposed to goethite NPs. One of the most notable effects on oxidative stress biomarkers was produced by single exposure to goethite NPs, showing that the worms were more sensitive to goethite NPs than to ZnO NPs. Acetylcholinesterase and carboxylesterase activities indicated that ZnO NPs alone were not neurotoxic to earthworms, but similar degrees of inhibition were observed after single CPF and ZnO NPs + CPF exposure. Differences between single and combined exposure were found for catalase and superoxide dismutase (goethite NPs) and for glutathione S-transferase (ZnO NPs) activities, mostly at 72h. These findings suggest a necessity to evaluate mixtures of NPs with co-existing contaminants in soil, and that the nature of metal oxide NPs and exposure time are relevant factors to be considered when assessing combined toxicity, as it may have an impact on ecotoxicological risk assessment.

Morphological effect on Core@shell AuAg nanoparticles for detecting p‐aminothiophenol dimerization by surface‐enhanced Raman spectroscopy

AbstractA series of non‐spherical metallic Au and bimetallic core@shell AuAg nanoparticles (NPs) have been synthesized for SERS improvements. The bimetallic core@shell AuAg NPs were obtained through a controlled overgrowth of an Ag shell onto the surface of two types of non‐spherical Au NPs, used as seeds, Au nanooctaheda (Au NOc) and Au nanotriangles (Au NTs). This Ag overgrowth was able to produce bimetallic core@shell structures such as nanocubes and nanopyramids, respectively. Transmission electron microscopy (TEM) was used to determine the particle size and particle morphology for metallic and bimetallic NPs, and energy‐dispersive X‐ray (EDX) elemental mapping analysis confirmed the core@shell structure of the bimetallic NPs. The plasmonic absorption bands exhibited for each nanosystem were observed by UV–vis spectroscopy. The concentration of Au and Ag in the bimetallic systems was determined by inductively coupled plasma mass spectrometry (ICP‐MS). After synthesis and characterization, p‐aminothiophenol (PATP) was used as a model analyte to investigate the surface‐enhanced Raman spectroscopy (SERS) capabilities of the synthesized metallic and bimetallic nanosystems. In PATP, a dimerization reaction to 4,4′‐dimercaptoazobenzene (DMAB) is produced when it is adsorbed onto the surface of certain noble metals. This SERS analysis was performed at 10−4 M of PATP and by using two different laser wavelengths (532 and 785 nm) in all cases. In this context, we were able to detect the dimerization reaction of PATP to DMAB only for the bimetallic structures and under the 532 nm laser line. Moreover, we have found that the dimerization capacity also depends on the nanoparticle morphology.

Perovskite Oxide Catalysts for Enhanced CO2 Reduction: Embroidering Surface Decoration with Ni and Cu Nanoparticles

The imperative reduction of carbon dioxide into valuable fuels stands as a crucial step in the transition towards a more sustainable energy system. Perovskite oxides, with their high compositional and property adjustability, emerge as promising catalysts for this purpose, whether employed independently or as a supporting matrix for other active metals. In this study, an A-site-deficient La0.9FeO3 perovskite underwent surface decoration with Ni, Cu or Ni + Cu via a citric acid-templated wet impregnation method. Following extensive characterization through XRD, N2 physisorption, H2-TPR, SEM-EDX, HAADF STEM-EDX mapping, CO2-TPD and XPS, the prepared powders underwent reduction under diluted H2 to yield metallic nanoparticles (NPs). The prepared catalysts were then evaluated for CO2 reduction in a CO2/H2 = 1/4 mixture. The deposition of Ni or Cu NPs on the perovskite support significantly enhanced the conversion of CO2, achieving a 50% conversion rate at 500 °C, albeit resulting in only CO as the final product. Notably, the catalyst featuring Ni-Cu co-deposition outperformed in the intermediate temperature range, exhibiting high selectivity for CH4 production around 350 °C. For this latter catalyst, a synergistic effect of the metal–support interaction was evidenced by H2-TPR and CO2-TPD experiments as well as a better nanoparticle dispersion. A remarkable stability in a 20 h time-span was also demonstrated for all catalysts, especially the one with Ni-Cu co-deposition.

Recent Developments of Nanostructured Photocatalysts Based on Semiconducting Chalcogenides for Organic Reactions

Abstract:: The earth-abundant metal chalcogenide is a highly versatile semiconductor with unique electronic and optical properties that seem to outperform the photocatalytic properties of metal oxides and metal nanoparticles. For ages, researchers are reaping the benefits of its photocatalytic properties in numerous reactions. However, the high charge recombination rates, poor compositional stability, and a smaller number of catalytically active sites restrict its application. The development of different kinds of heterojunctions by the combination of metal-chalcogenides with other conducting and semiconducting materials like metal oxides, metal nanoparticles, g-C3N4, single-atom catalysts, and MOF results in superior photocatalytic activity. This review provides insight into the various classes of metal-chalcogenide-based heterostructures and their application in various organic transformations. A brief overview of the synergistic properties arising from the development of such heterostructures helps to understand the surface interactions so that highly stable, efficient, and selective metal-chalcogenide-based heterostructures can be developed for industrially important photocatalytic organic transformations. This review also describes the role of mediators in boosting the stability and catalytic efficiency of the metal chalcogenides. Moreover, a thorough emphasis on the morphological impact of photocatalysts in various reactions will help with the development of metal chalcogenide heterostructures with tunable morphology and bandgap.

Biomaterials for Targeting Endoplasmic Reticulum in Cancer.

Endoplasmic reticulum (ER) is one of the most important sub-cellular organelles which controls myriads of biological functions including protein biosynthesis with proper functional folded form, protein misfolding, protein transport into Golgi body for secretion, Ca2+ homeostasis and so on. Subsequently, dysregulation in ER function leads to ER stress followed by disease pathology like cancer. Hence, targeting ER in the cancer cells emerged as one of the futuristic strategies for cancer treatment. However, the major challenge is to selectively and specifically target ER in the sub-cellular milieu in the cancer tissues, due to the lack of ER targeting chemical moieties to recognize the ER markers. To address this, in last decade, numerous biomaterials were explored to selectively impair and image ER in cancer cells to induce ER stress. This review outlines those biomaterials which consists of carbon and silicon materials, lipid nanoparticles (liposomes and micelles), supramolecular self-assembled nanostructures, cell membrane coated nanoparticles and metallic nanoparticles. Moreover, we also discussed the challenges and possible solutions of this promising field to usher the readers towards next-generation ER targeted cancer therapy.

Plasma-deposited reactive species assisted synthesis of colloidal zinc-oxide nanostructures

A surface-wave microwave discharge is applied to deposit reactive oxygen and nitrogen species (RONS) into the liquid subsequently used as a medium for laser ablation of a Zn metallic target. It is shown that during laser ablation in plasma-treated liquids the H2O2 concentration decreases, while in deionized water (DIW) significant H2O2 is produced. Meanwhile, the pH—initially adjusted by applying reductive metals—increases in the acidic liquids and decreases in the alkaline ones. During months of storage the pH of colloids stabilize around pH 6, which insures the long-term stability of RONS. It is demonstrated that in DIW metallic Zn NPs are created, which gradually oxidize during storage, while in the plasma-treated liquids ZnO NPs are produced with the mean size of 18 nm. In the alkaline plasma-treated liquid the NPs form large aggregates, which slows the dissolution of NPs. In the acidic and neutral solutions besides NPs nanosheets are also formed, which during storage evolve into nanosheet networks as a result of the dissolution of NPs. The band gap of the colloidal ZnO is found to decrease with the formation of aggregates and nanosheet networks. The ZnO NPs ablated in plasma-treated liquids exhibit a high-intensity visible emission covering the green-to-red spectral region. The photoluminescence spectra is dominated by the orange-red emission—previously not detected in the case of laser-ablated ZnO NPs and attributed to the interstitial Zn and oxygen sites—and the yellow emission, which can be attributed to the OH groups on the surface. It is shown that during months of storage, due to the dissolution of NPs and formation of nanosheets, the intensity of the visible emission decreases and shifts to the blue-green spectral region.

Dynamic Active Sites In Situ Formed in Metal Nanoparticle Reshaping under Reaction Conditions

Dynamic Active Sites In Situ Formed in Metal Nanoparticle Reshaping under Reaction Conditions

Green Synthesis of Silver Nanoparticles and their Potential Applications in Mitigating Cancer.

In recent years, the field of nanotechnology has brought about significant advancements that have transformed the landscape of disease diagnosis, prevention, and treatment, particularly in the realm of medical science. Among the various approaches to nanoparticle synthesis, the green synthesis method has garnered increasing attention. Silver nanoparticles (AgNPs) have emerged as particularly noteworthy nanomaterials within the spectrum of metallic nanoparticles employed for biomedical applications. AgNPs possess several key attributes that make them highly valuable in the biomedical field. They are biocompatible, cost-effective, and environmentally friendly, rendering them suitable for various bioengineering and biomedical applications. Notably, AgNPs have found a prominent role in the domain of cancer diagnosis. Research investigations have provided evidence of AgNPs' anticancer activity, which involves mechanisms such as DNA damage, cell cycle arrest, induction of apoptosis, and the regulation of specific cytokine genes. The synthesis of AgNPs primarily involves the reduction of silver ions by reducing agents. Interestingly, natural products and living organisms have proven to be effective sources for the generation of precursor materials used in AgNP synthesis. This comprehensive review aims to summarize the key aspects of AgNPs, including their characterization, properties, and recent advancements in the field of biogenic AgNP synthesis. Furthermore, the review highlights the potential applications of these nanoparticles in combating cancer.