Metabolic Illness Research Articles

Study of the Human Physiological Aspect of all Component of Medo Dhatu

According to Ayurveda, human physiology is dependent on the balance of Dosha, Dhatu, and Mala. Dhatus are regarded to be one of the body's most fundamental functioning and structural components. According to Ayurveda, human physiology consists of seven primary Dhatus. Medo Dhatu ranks fourth among the seven Dhatus. Lipids are discussed in terms of Sneha Dravya in Ayurveda, which includes Meda, Vasa, Majja, and so on. Sneha is the essence of our bodies. Acharya Sushruta states that the human body is made up of Snehasara, the most Vishuddhatara form of Sneha, and that Prana is dependent on it. Meda is mostly found in Udara, although it is also known as Sarakta Meda in Anu (little) Asthi and Majja in Sthoola (big) Asthi. Mamsa contains a pure form of Meda known as Vasa. Although these three are the most visible Sneha sites, Meda Dhatu is given special attention because of their relevance in lipid metabolism and participation in the development of numerous metabolic illnesses such as Medoroga and Prameha. The present review article focused on all physiological component of Medodhatu and its role in maintaining the physiology.

The systematic review on Madhumeha w.r.t. Diabetic Neuropathy and its management: A review article

The world's fastest-growing major illness is diabetes mellitus. It's a metabolic illness that could lead to an insufficiency or malfunction in the production of insulin. Many of the Samhitas contain detailed descriptions of Madhumeha. Diabetic neuropathy is most common complication of Diabetes, approximately 50% of patients with diabetes eventually develop neuropathy. Symptoms of diabetic neuropathy not directly mentioned in Ayurveda but symptoms like Suptata, Chumchumayan, Karpada Daha, seen in Prameha either in Prameha prodomal stage, exhibition stage or in complication stage. As Samprapti of diabetic neuropathy not clearly mentioned in Samhitas so, after reviewing different Samhitas, a Samprapti has been suggested with possible management of Diabetic neuropathy in Ayurveda i.e., Shodhan and Samana Chikitsa and mode of action of Shodhan Chikitsa.

Epigenetics in obesity: Mechanisms and advances in therapies based on natural products.

Obesity is a major risk factor for morbidity and mortality because it has a close relationship to metabolic illnesses, such as diabetes, cardiovascular diseases, and some types of cancer. With no drugs available, the mainstay of obesity management remains lifestyle changes with exercise and dietary modifications. In light of the tremendous disease burden and unmet therapeutics, fresh perspectives on pathophysiology and drug discovery are needed. The development of epigenetics provides a compelling justification for how environmental, lifestyle, and other risk factors contribute to the pathogenesis of obesity. Furthermore, epigenetic dysregulations can be restored, and it has been reported that certain natural products obtained from plants, such as tea polyphenols, ellagic acid, urolithins, curcumin, genistein, isothiocyanates, and citrus isoflavonoids, were shown to inhibit weight gain. These substances have great antioxidant potential and are of great interest because they can also modify epigenetic mechanisms. Therefore, understanding epigenetic modifications to target the primary cause of obesity and the epigenetic mechanisms of anti-obesity effects with certain phytochemicals can prove rational strategies to prevent the disease and develop novel therapeutic interventions. Thus, the current review aimed to summarize the epigenetic mechanisms and advances in therapies for obesity based on natural products to provide evidence for the development of several potential anti-obesity drug targets.

Kynurenines, Neuronal Excitotoxicity, and Mitochondrial Oxidative Stress: Role of the Intestinal Flora.

The intestinal flora has been the focus of numerous investigations recently, with inquiries not just into the gastrointestinal aspects but also the pathomechanism of other diseases such as nervous system disorders and mitochondrial diseases. Mitochondrial disorders are the most common type of inheritable metabolic illness caused by mutations of mitochondrial and nuclear DNA. Despite the intensive research, its diagnosis is usually difficult, and unfortunately, treating it challenges physicians. Metabolites of the kynurenine pathway are linked to many disorders, such as depression, schizophrenia, migraine, and also diseases associated with impaired mitochondrial function. The kynurenine pathway includes many substances, for instance kynurenic acid and quinolinic acid. In this review, we would like to show a possible link between the metabolites of the kynurenine pathway and mitochondrial stress in the context of intestinal flora. Furthermore, we summarize the possible markers of and future therapeutic options for the kynurenine pathway in excitotoxicity and mitochondrial oxidative stress.

Comparative study of allopathy and ayurveda for treatment of diabetes mellitus

These days, one of the most prevalent non-communicable diseases is diabetes mellitus. It has an impact on people worldwide of all ages and their families, and it heavily strains national budgets and healthcare systems. In the short term, implementing a comprehensive healthcare management program for individuals with diabetes can result in significant improvements in clinical outcomes and costs. Millions of people throughout the world suffer from diabetes mellitus, a chronic metabolic illness. To avoid complications and enhance the quality of life for those with diabetes, management is crucial. The two main methods used to treat diabetes are Ayurveda, an ancient system of traditional medicine, and Allopathy, a conventional medical system. The purpose of this study is to compare and contrast these two methods for treating diabetes. The study includes a thorough analysis of the research on diabetes treatment in allopathy and ayurveda, as well as clinical studies and expert opinions.

Comparison of pain during heel prick in preterm neonates receiving only expressed breast milk and expressed breast milk with kangaroo mother care

Background: Newborns' heels are sampled for blood, which is crucial in the identification of genetic and metabolic illnesses. Repeated painful stimulation impairs the future development of their normal motor and cognitive functions. Hence it is necessary to find out suitable remedy to alleviate the pain. The aim of this study was to observe the premature newborns' response to pain (Heel prick) by giving either single (EBM) or combined (EBM and KMC). Methods: The analytical cross-sectional study was conducted in NICU of SMIMER. hospital, Surat from March 2022 to February 2023. The study included 56 premature newborns, divided into three groups. Group A received only EBM, Group B received EBM and KMC (15 minutes), and Group C received EBM and KMC (30 minutes) before the heal prick. The pain was assessed by PIPP score in all three groups at the end of 30,60 and 120 seconds after the procedure. Data were analyzed using SPSS 24 and a one-way ANOVA test was applied. Results: The PIPP score after 60 seconds between Group A with B and A with C was statistically significant (p<0.05) whereas Group B with C was insignificant (p>0.05). The score after 60 seconds between Group A with B and A with C was statistically significant (p<0.05) whereas Group B with C was insignificant (p>0.05). Conclusions: EBM with KMC (15 minutes) duration had an effective impact on pain relief as compared to EBM with KMC (30 minutes) duration at the interval of 60 seconds.

The Role of GLP-1, GIP, MCP-1 and IGFBP-7 Biomarkers in the Development of Metabolic Disorders: A Review and Predictive Analysis in the Context of Diabetes and Obesity.

Metabolic illnesses, including obesity and type 2 diabetes, have become worldwide epidemics that have an effect on public health. Clinical investigations and further exploration of these mechanisms could lead to innovative, effective, and personalized treatment strategies for individuals. It is important to screen biomarkers in previous studies to discover what is missing. Glucagon-like peptide-1's role in insulin secretion and glucose control highlights its diagnostic and therapeutic potential. Glucose-dependent insulinotropic peptide's influence on postprandial satiety and weight management signifies its importance in understanding metabolic processes. Monocyte chemoattractant protein-1's involvement in inflammation and insulin resistance underlines its value as a diagnostic marker. Insulin-like growth factor-binding protein-7's association with insulin sensitivity and kidney function presents it as a potential target for these diseases' management. In validating these biomarkers, it will be easier to reflect pathophysiological processes, and clinicians will be able to better assess disease severity, monitor disease progression, and tailor treatment strategies. The purpose of the study was to elucidate the significance of identifying novel biomarkers for type 2 diabetes mellitus and obesity, which can revolutionize early detection, risk assessment, and personalized treatment strategies. Standard literature searches of PubMed (MEDLINE), EMBASE, and Cochrane Library were conducted in the year 2023 to identify both original RCTs and recent systematic reviews that have explored the importance of identifying novel biomarkers for T2D and obesity. This search produced 1964 results, and then was reduced to randomized controlled trial and systematic reviews, producing 145 results and 44 results, respectively. Researchers have discovered potential associations between type 2 diabetes mellitus and obesity and the biomarkers glucagon-like peptide-1, glucose-dependent insulinotropic peptide, monocyte chemoattractant protein-1, and insulin-like growth factor-binding protein-7. Understanding the role of those biomarkers in disease pathogenesis offers hope for improving diagnostics, personalized treatment, and prevention strategies.

The management of post-stroke pain

Stroke is a metabolic illness that causes significant impairment in the working-age population. Disability develops due to the consequences of neurological deficiencies and the failure of the medical rehabilitation process. Post-stroke pain is one of the causes of this failure. In a post-stroke patient, pain is an unpleasant physical and emotional experience. In contrast, range of motion barriers might cause the medical rehabilitation procedure to fail. This paper aims to review the various methods of post-stroke pain management that can be used as an alternative therapy that helps post-stroke patients' rehabilitation. The PubMed database was used to search for different kinds of literature. The study includes clinical studies, pilot studies, and randomized control trials published between January 2015 and June 2023. The authors omit several publications to ensure that the final selection of papers includes only the most relevant and reputable sources of information on post-stroke pain, post-stroke pain management, and pain as a measure of outcome. There are 28 publications to be reviewed. The most prevalent cause of post-stroke pain was hemiplegic shoulder pain in numerous studies that have an impact on the post-stroke recovery process. In conclusion, the options for post-stroke therapy range from conservative rehabilitation to interventional therapy. Several innovative experimental rehabilitation treatment approaches have been studied. However, the findings do not outperform conventional rehabilitation treatment.

Evaluation of In vitro Antioxidant and Antidiabetic activity of a Polyherbal formulation

Recent years have seen significant improvements in the identification, management, and study of metabolic illnesses, particularly diabetes. In addition to the present synthetic medicines, current research is focused on developing an alternate source of medication from natural resources for managing diabetes. Objective: To investigate the antioxidant and antidiabetic efficacy of a poly-herbal formulation (PHF) by in vitro models. Methods: The Polyherbal formulation was screened for the presence of phytochemical constituents. The total phenolic and flavonoids content of the formulation was also analysed. The in vitro antioxidant and antidiabetic activity of the formulation (PHF) were calculated. Results: The Polyherbal formulation showed presence of phenols, flavonoids, steroids, and saponins. The IC50 value of PHF4 was found to be 42.70µg/ml in DPPH radical scavenging assay. It has shown high levels of phenols (172.6±0.68 mg/g), flavonoids (137.3±0.91 mg/g) and had IC50 values of 422.50 µg/ml and 438.71 µg/ml for amylase and glucosidase, respectively. Conclusion: The results indicate that Polyherbal Formulation (PHF4) had significant antioxidant activity as well as a strong inhibitory effect on α -amylase and α -glucosidase. However, for further validation of the above findings, in vivo antidiabetic study of polyherbal formulation will be carried out using animal models.

Benefit-Risk Assessment of ChatGPT Applications in the Field of Diabetes and Metabolic Illnesses: A Qualitative Study.

The use of ChatGPT and artificial intelligence (AI) in the management of metabolic and endocrine disorders presents both significant opportunities and notable risks. To investigate the benefits and risks associated with the application of ChatGPT in managing diabetes and metabolic illnesses by exploring the perspectives of endocrinologists and diabetologists. The study employed a qualitative research approach. A semi-structured in-depth interview guide was developed. A convenience sample of 25 endocrinologists and diabetologists was enrolled and interviewed. All interviews were audiotaped and verbatim transcribed; then, thematic analysis was used to determine the themes in the data. The findings of the thematic analysis resulted in 19 codes and 9 major themes regarding the benefits of implementing AI and ChatGPT in managing diabetes and metabolic illnesses. Moreover, the extracted risks of implementing AI and ChatGPT in managing diabetes and metabolic illnesses were categorized into 7 themes and 14 codes. The benefits of heightened diagnostic precision, tailored treatment, and efficient resource utilization have potential to improve patient results. Concurrently, the identification of potential challenges, such as data security concerns and the need for AI that can be explained, enables stakeholders to proactively tackle these issues. Regulatory frameworks must evolve to keep pace with the rapid adoption of AI in healthcare. Sustained attention to ethical considerations, including obtaining patient consent, safeguarding data privacy, ensuring accountability, and promoting fairness, remains critical. Despite its potential impact on the human aspect of healthcare, AI will remain an integral component of patient-centered care. Striking a balance between AI-assisted decision-making and human expertise is essential to uphold trust and provide comprehensive patient care.

Author Response to Comment on: "Benefit-Risk Assessment of ChatGPT Applications in the Field of Diabetes and Metabolic Illnesses: A Qualitative Study".

Author Response to Comment on: "Benefit-Risk Assessment of ChatGPT Applications in the Field of Diabetes and Metabolic Illnesses: A Qualitative Study".

Impact of lifestyle modification on nonalcoholic fatty liver with prediabetes and type 2 diabetes

Prediabetes is characterized by impaired glucose uptake and insulin sensitivity in the muscle, as well as a significant risk of developing diabetes, chronic renal disease, cardiovascular disease, and death. A definite bidirectional connection exists between pre-diabetes, diabetes, and NAFLD. The presence of NAFLD is associated with the subsequent development of new-onset type 2 diabetes (T2DM). There was a 6-fold rise in new-onset diabetes in people whose fatty liver severity progressed from mild to moderate or severe over 5 years, and a decrease in T2DM incidence comparable to that in those without steatosis. Insulin resistance is a common pathophysiological mechanism across metabolic illnesses, including prediabetes, diabetes, and NAFLD. As a result, better names for metabolically linked metabolic fatty liver disease have been considered. Lifestyle is the cornerstone of treatment for patients with prediabetes, T2DM, and NAFLD. Several significant randomized controlled trials show that a customized low-calorie meal plan and behavioral change are highly effective in preventing or delaying prediabetes, type 2 diabetes, and improving other cardiometabolic markers (such as blood pressure, lipids, and inflammation). Several drugs already approved for the treatment of prediabetes and diabetes are beneficial for NAFLD/NASH.

Benefit-Risk Assessment of ChatGPT Applications in the Field of Diabetes and Metabolic Illnesses: Correspondence.

Benefit-Risk Assessment of ChatGPT Applications in the Field of Diabetes and Metabolic Illnesses: Correspondence.

Exploring the Impact of Social Media on Attaining HbA1c Targets in Individuals with Type 2 Diabetes Mellitus in Iraq: A Cross-Sectional Study.

Type 2 diabetes mellitus (T2DM) is a persistent metabolic illness causing elevated glucose levels due to insulin resistance. Social media has been found to positively impact diabetes management by boosting motivation, adherence, emotional support, and sharing evidence-based information, thereby enhancing patients' glycemic control efforts and achieving HbA1c targets. Primarily to examine the influence of social media within a random sample Iraqi population of T2DM patients on the control of diabetes, as measured by HbA1c levels. A multicentric cross-sectional study involves patients diagnosed with T2DM recruited between December 30, 2019 and November 8, 2023. Patients diagnosed with T2DM, who visited the outpatient clinic at least twice during the study period, were included. The sample size comprised 2921 patients. Various social media platforms available including, Facebook, WhatsApp, Instagram, Telegram, X (formerly known as Twitter), and Viber, were reported. The study involves 2921 participants with a mean age of 53.3 years, 56% of them successfully reached their HbA1c target within a mean of 18.17 months. A significant correlation was found between achieving the target and using social media (P = .0001), with a shorter average duration among social media users compared to non-users. A family history of diabetes also significantly correlated with achieving the desired outcome, suggesting a probable positive correlation (P = .019). The study reveals a significant association between social media usage and glycemic control, introducing the importance of technology-based interventions in enhancing diabetes self-management, highlighting the relationships between social media engagement and HbA1c target achievement.

Toxicological Assessment and Anti-diabetic Effects of Combined Extract of Chirata, Fenugreek and Sesame on Regulating TNF-α, TGF-β and Oxidative Stress in Streptozotocin Induced Diabetic Rats.

Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum are used as traditional medicines to treat diabetes mellitus. A collection of metabolic illnesses known as diabetes mellitus (DM) involves chronic hyperglycemia caused by flaws in insulin secretion, function, or both. Innate immunity and inflammation both play important roles in the etiology of diabetes- related microvascular problems. This study aims to examine the anti-diabetic effects and the acute toxicity of combined extract (1:1:1) of Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum. To address the demand for higher effectiveness and safety, the current effort aims to construct anti-diabetic preparations containing methanolic extract from herbal medications. The OECD 423 method was used to investigate acute toxicity in rats. Rats were used as test subjects, and rats were given a 35 mg/kg BW injection of streptozotocin to develop diabetes. The diabetic control group was given Glibenclamide 0.25 mg/kg BW, while the experimental group's diabetic rats received 125 mg/kg BW and 250 mg/kg BW of a combined methanolic extract of all plants. Among the measurements looked at were acute oral toxicity, behavioral changes, body weight, serum glucose levels, lipid profiles, oxidative stress, renal function tests, and inflammatory mediators. All the rat groups' histopathologies of the kidney, liver, and stomach were compared. The data were evaluated using analysis of variance, and a post hoc test was then carried out. The combined extracts' medium lethal doses (LD50) were higher than 2000 mg/kg, indicating that they are not poisonous under the conditions that can be observed. Streptozotocin-induced diabetic rats' elevated blood glucose was found to be considerably lower (p 0.01) in the treated group of rats. In the treated group of rats, it was discovered that the damage and disarray in the cells typical of Streptozotocin-induced DM had been repaired. The treated group of rats returned to normal levels of the lipid profile, hyperglycemia, decreased serum protein and liver glycogen, increased liver function, and kidney function markers seen in the rats of the DM control group. The evaluated combined methanolic extract can be considered safe for use in rats. Combining methanolic extract from all selected medicinal plants (Swertia chirayita, Trigonella foenum-gracum and Sesamum indicum) has a potential anti-diabetic effect and can be safely developed as an alternative medicine.

Multi-omics characterization of type 2 diabetes mellitus-induced gastroenteropathy in the db/db mouse model.

Gastrointestinal dysfunction are often associated with type 2 diabetes mellitus (T2DM), a complicated metabolic illness. Contributing factors have been proposed, including genetic predisposition, gene environmental, and lifestyle interactions, but the pathophysiology remains unknown. We aim to explore the possible causes behind gastrointestinal dysfunction caused by type 2 diabetes in this study. A comprehensive analysis of the gastric sinus metabolome, transcriptome, and proteome in db/db mice with gastrointestinal dysfunction was conducted. The model group of mice had considerably lower small intestine propulsion and gastric emptying rates, higher blood glucose levels, and were significantly obese compared to the control group. We identified 297 genes, 350 proteins, and 1,001 metabolites exhibiting significant differences between db/db and control mice (p < 0.05). Moreover, multi-omics analysis revealed that the genes, proteins, and metabolites in the T2DM-induced gastroenteropathy mice group were involved in arachidonic acid metabolism, glycerophospholipid metabolism and vitamin digestion and absorption. Specifically, Cbr3, Etnppl, and Apob were the major mRNAs associated with T2DM-induced gastrointestinal dysfunction, while Cyp2b10, Cyp2b19, Pgs1, Gpat3, Apoa4, and Tcn2 were the major proteins associated with T2DM-induced gastrointestinal injury, and 16(R)-HET, 5-HETE, LysoPC (22:0), and Pantothenic acid were the major metabolites associated with T2DM-induced gastrointestinal disorders. The mechanism of action of diabetic gastroenteropathy may be related to vitamin digestion and absorption, glycerophospholipid metabolism, and arachidonic acid metabolism.

The lived experience of young adults emotionally labouring with type 1 diabetes: Findings of an interpretive phenomenological study

BackgroundType 1 diabetes is a life-long metabolic illness. Typically diagnosed in childhood, adolescence, and young adulthood, this diagnosis is often associated with increased psychological vulnerability. Diabetes distress is associated with the daily demands of managing complicated medication and dietary regimes that are emotionally, psychologically, and physically taxing. Emotional labour may be required to manage or negotiate the demands of diabetes distress. Emotional labour is the process of managing feelings and expressions that come with fulfilling the emotional demands of necessary tasks or roles. However, the meaning of emotional labour has not been explored for young people living with Type 1 diabetes. MethodsUsing Interpretive Phenomenological Analysis, we conducted this study to explore the lived experience of emotional labour for young adults living with Type 1 diabetes in adulthood. ResultsThemes were identified that constituted sources of emotional labour inherent to participants’ experiences of diabetes management. The over-expenditure of emotional labour suggests profound implications for mental health outcomes and diabetes distress levels, and participant experiences revealed institutionally imbedded ableism that elicited further expenditure of emotional labour. ConclusionThe findings suggest that reconsideration of educational frameworks and praxis within diabetes healthcare may alleviate emotional labour and diabetes distress.

In-silico Study of Epicathecin from Cinnamomum verum Against Insulin Receptor for Diabetes Mellitus

Obesity has become more common in recent years. Fatalism can raise the chance of fatal metabolic and cardiovascular diseases. Type 2 diabetes is one of the metabolic illnesses brought on by fat. Insulin receptor resistance, also known as non-insulin dependent type 2 diabetes, is a consequence of type 2 diabetes. Reduced insulin sensitivity and the inability of pancreatic beta cells to produce enough insulin to offset the development of resistance are the main causes of type 2 diabetes mellitus. Insulin receptor problems that decrease INSR expression on the cell surface and follow receptor abnormalities are the common mechanisms behind insulin receptor resistance. The single-nucleotide found in INSR. Increasing the expression of 4IBM is one strategy to combat its effects on insulin receptor function and increased risk of INSR-mediated illnesses. Based on earlier studies, cinnamon (Cinnamomum verum), a traditional plant, has been shown to have potential as a treatment for a number of illnesses, including diabetes mellitus. Using Autodock 4 and the Lamarckian genetic algorithm as a basis, this in-silico study intends to investigate the potential of active compounds found in cinnamon and their role as 4IBM protein inhibitors for therapy in type 2 diabetes mellitus. The binding energy ranged from -7.95 to -6.15 kcal/mol, according to docking data, with the compound epicatechin having the lowest binding energy and an inhibitory constant of 7.80. Further investigation into the active ingredients in cinnamon and their potential use in the treatment of diabetes mellitus can be based on the findings of this study.

POST-VACCINATED COVID-19 OXIDATIVE STRESS IN MENOPAUSE FEMALES

After 12 months of amenorrhea (absence of menses) and the irreversible termination of ovarian activity, menopause is identified. Menopause has a number of physiological implications, including increased abdominal obesity and a higher risk of cardiovascular and metabolic illness. Hot flashes (HF), headaches, back discomfort, stiff joints, weariness, and difficulty sleeping are all signs of menopause. Menopause begins around the age of 51. Menopause occurs prematurely in 0.3–1.1% of women. During menopause, oxidant stress (hydrogen peroxide and superoxidant anion) increases the formation of free radicals. Intermediates in enzymatic reactions that occur during cell metabolism (reactive oxygen species and reactive nitrogen) sometimes leak from enzyme molecules and interact with molecular oxygen, creating free oxygen free radicals. The molecular basis of cancer, neurodegenerative and cardiovascular diseases, diabetes, and autoimmune disorders is oxidative stress caused by free oxygen radicals. HF and irregular menses are common complaints among women, as seen in many blog entries, so there may be some research to be done. Oxidative stress causes COVID-19 post-vaccination side effects. Antioxidant supplements and menopausal hormonal treatment may lower oxidative stress and inflammation. The focus of this research is to see how oxidative stress and quality of life levels change after receiving the COVID-19 vaccination, which is used to treat HF associated with menopause.

Visceral adipose tissue triggers tau pathogenesis in transgenic mice

AbstractBackgroundAlzheimer’s disease (AD) is a complex disorder and multiple cellular and molecular mechanisms are involved in AD onset and progression. Recent evidences have suggested that metabolic alterations are an important pathological feature in disease progression in AD. Likewise, diabetes and obesity, two mayor metabolic illnesses, are risk factors for AD. These two overwhelming diseases are associated with a significant expansion of visceral adipose tissue. Here, we hypothesize that the visceral adipose tissue may serve as a key communicator organ between the brain and peripheral metabolic illnesses and affecting both types of disorders.MethodWe used histological stains, immunohistochemistry and biochemical means to determine changes in the visceral adipose tissue from WT and db/db mice. Moreover, similar techniques were used in 3xTg‐AD mice that received white fat pads from WT and db/db donors to determine any changes in amyloid and tau pathology.ResultOur study shows that recipient 3xTg‐AD mice from db/db fat pads mice develop profound changes in tau pathology due to increased CDK5 expression compared to 3xTg‐AD mice that received fad pads from WT mice. This increment in tau level was associated with elevated levels in IL‐1β and profound microglia activation. Moreover, we found the opposite effect on amyloid pathology, in which insoluble Aβ levels and Thioflavin positive plaques were reduced in recipient 3xTg‐AD mice from db/db fat pads compared to 3xTg‐AD mice that received fad pads from WT mice. These reduction in Aβ levels were correlated with an increment in microglia phagocytic capacity.ConclusionOverall, our study demonstrate a novel important crosstalk between Alzheimer´s disease and obesity/diabetes type II through visceral adipose cells and a differential effect on tau and Aβ pathology mediated by an activated immune response.This study was supported by Minister of Science and Innovation grant PID2019‐108911RA‐100 (D.B.V.), Alzheimer’s Association grant AARG‐22‐9282/9, Beatriz Galindo program BAGAL18/00052 (D.B.V.), University of Malaga grant PPIT.UMA.B1‐2021_32(LTE) and Institute of Health Carlos III (ISCiii) grant PI18/01557 (A.G.) co‐financed by FEDER funds from European Union.