Merging Point Research Articles

Robust and Fast CAD Model Tessellation for Inspection

The digital manufacturing deviation inspection can be used to assess the dimension, form, and position errors, which is more efficient, more consistent, and more robust than manual inspection. CAD models are used as the nominal data and compared with the scanned data of parts to obtain manufacturing errors. CAD model tessellation is a pivotal step in deviation inspection, which directly determines the reliability of analytical results. It requires that the generated triangle mesh has dense vertices, high approximation accuracy, and consistent orientation. A single surface patch tessellation method is proposed, and the adaptive quadtree is first constructed to divide the domain into small spatial grids in the parameter space of the patch; then, a clip-based method is presented to triangulate boundary grids, and inner grids could be triangulated by the constrained Delaunay triangulation method. Furthermore, the mesh patches should be spliced and reoriented consistently, which is very important for deviation analysis. To solve this problem, a robust gap healing method based on merging boundary points of patches is developed, so that all boundary vertices of adjacent patches could completely coincide along the common edges, and all mesh patches would be stitched into a complete mesh without gaps. Finally, the face normal of mesh is adjusted to obtain a consistent orientation. Experiments on industrial CAD models demonstrate that the proposed method could realize faster and more robust mesh generation than the state-of-the-art approaches, including three commercial and two open-source software.

Construction of a Wide-Area 3D Point Cloud Map by Merging Point Cloud Maps

Construction of a Wide-Area 3D Point Cloud Map by Merging Point Cloud Maps

合流路での車列間に入るための車速制御方法

A method of controlling the acceleration required for merging between the vehicles on a main road was investigated. The vehicles on the main road usually keep speed near junctions. In order to prevent collisions, at the time of merging, the speed of ego vehicle, and the inter-vehicle distance of object vehicles on the main road and the distance to the merging point are measured previously. Using these parameters, we derived a calculation method of the acceleration required for safe merging between the vehicles on a main road. In addition, as the acceptable upper and lower limits of the vehicle's acceleration are defined. It is possible to predict whether the vehicle can safely merge with acceptable acceleration/deceleration.

The fuel consumption impact of the turning point location for the point merge system

The fuel consumption impact of the turning point location for the point merge system

The fuel consumption impact of the turning point location for the point merge system

The fuel consumption impact of the turning point location for the point merge system

Assessing the quality consistency of Rong'e Yishen oral liquid by five-wavelength maximization profilings and electrochemical fingerprints combined with antioxidant activity analyses

Quality consistency control of traditional Chinese medicine (TCM) is often essential for providing reference and procedure to guarantee the safety and effectiveness of TCM. Taking Rong'e Yishen oral liquid (REYS) as an example, five-wavelength maximization profilings (FWMPs) of 21 samples were constructed to fully manifest the maximum UV absorption characteristics at multi-wavelength. The preliminary analysis of FWMPs by principal component analysis (PCA) suggested us focusing on evaluating the quality consistency qualitatively and quantitatively by systematically quantified fingerprint method (SQFM). Meanwhile, electrochemical fingerprints (ECFPs) were established and the related characteristic parameters were deeply analyzed. All the samples had inhibitory effect on the electrochemical oscillation system, and the oscillation life (tol) was linear with the added volume and temperature in a certain range, respectively (r > 0.94). The merging point method was first introduced to process ECFP to facilitate its evaluation with SQFM. The evaluation results of FWMPs and the merged ECFPs were integrated in an equal weight for assessing the sample quality completely, and 21 samples were classified into two grades with good quality consistency. Furthermore, 2, 2-azino-bis (3 - ethyl - benzthiazoline - 6 - sulfonic acid) (ABTS) scavenging assay was applied to study the antioxidant activity of samples using vitamin C as a positive control. Partial least squares (PLS) model and bivariate correlation analysis (BCA) was used for FWMP-ABTS efficacy relationship and FWMP-merged ECFP efficacy relationship respectively. 15 of the 48 co-possessing peaks made important contributions to the two efficacy relationships simultaneously. This study suggested a comprehensive and reliable approach for quality consistency control of complex TCM or herbal medicine.

The flight efficiency analysis on the Multi-Arrival Route Point Merge System

AbstractThis study proposes a new operational concept of the Point Merge System, called Multi-Arrival Route Point Merge System (MAR-PMS), which is an air traffic control method used to sequence aircraft arrivals in a given terminal control area. The proposed concept enables the additional arrival routes that have an angular difference to each sequencing leg. Furthermore, a time-indexed 0-1 linear programming model is formulated. The obtained results are validated in a real time simulation. The comparison results of PMS and MAR-PMS show that the average reduction of 19% of total flight time, 23% of total flight distance, and 19% in total fuel burned and reduction in CO2 emissions in favor of a proposed concept.

Exploration and Practice of Ideological and Political Theories Teaching in Operations Research Courses Based on the “Trinity”

This study analyzes the background of ideological and political theories teaching in operations research courses and provides a design framework for ideological and political theories teaching in operations research courses based on “trinity” according to real teaching practices. This article summarizes the merging point of ideological and political theories teaching in operations research courses, taking ability and knowledge as its carrier and ideological and political theories teaching as its core, as well as discusses four methods of ideological and political theories teaching: online and offline interactive teaching, stimulating independent learning by practical application, seminar-style flipped classroom, and promoting theoretical teaching through competition and scientific research.

A Graph-Based Optimal On-Ramp Merging of Connected Vehicles on the Highway

Connected and automated vehicles (CAVs) are a very promising alternative for reducing fuel consumption and improving traffic efficiency when vehicles merge at on-ramps. In this study, we propose a graph-based method to coordinate CAVs to merge at the highway ramp. First, the optimized vehicles were divided into groups to pass the merging point. Then we built a directed graph model for each group of vehicles, where each path of the graph corresponds to one of all possible merging sequences. The improved shortest path algorithm is proposed to find the optimal merging sequence for minimizing total fuel consumption. The results of the simulation showed that the proposed graph-based method reduced fuel consumption and ensured high traffic efficiency; moreover, the vehicles can form a platoon after passing the merge point.

Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs Inducing Synergistic Anti-Myeloma Activity

INTRODUCTIONTranscription factors (TFs) are convergence points of signaling cascades that coordinate cell differentiation, proliferation and survival and are commonly deregulated in cancer, including multiple myeloma (MM). They contribute to the initiation of MM and promote tumor cell growth and drug resistance. Both cMyc, a merging point of the PI3K-, and JunB, a merging point of the MEK/MAPK-signaling pathway, play pivotal roles in MM. Exciting novel approaches to inhibit TFs like proteolysis-targeting-chimera (PROTAC) promise to lead to selective tumor cell death with little/no consequence for normal cells. However, redundancy phenomena of transcriptional programs are likely to challenge their efficacy. Here, we report our final results on combined targeting of distinct c-Myc & JunB transcriptional programs for MM therapy.METHODSMM cell lines and patient MM cells were analyzed. Following CRISPR-loss-of-function screens for cMyc & JunB across MM cell lines and correlation analyses in MM patient datasets, the functional relevance of BRD4/c-Myc- and MEK/JunB-induced TF programs was delineated using genomic and chemical approaches in 2D and 3D models of the bone marrow (BM) microenvironment. Specifically, effects of single or combined targeting of cMyc- and JunB-induced TF-programs were analyzed by flow cytometry, western blot, RNAseq, qPCR and luciferase assays. In vitro and ex vivo results were finally verified in a MM xenograft mouse model.RESULTSWhile CRISPR loss-of-function screens across various MM cell lines confirmed their growth dependency on cMyc and JunB, we did not observe correlative expression levels among these TFs, neither in the publicly available GSE6477 nor in the CoMMpass dataset. In contrast, a significant positive correlation was observed between Brd4 and cMyc, and MEK and JunB expression levels, respectively. The existence of two distinct Brd4/cMyc and MEK/JunB transcriptional programs in MM cells was subsequently supported by a lack of changes in cMyc mRNA/protein levels and resultant transcriptional activity upon JunB knockdown, and vice versa. Likewise, MZ-1, a novel PROTAC which targets Brd4, resulted in the inhibition of BMSC/IL-6- induced cMyc- but not JunB- upregulation. Conversely, neither the MEK inhibitor trametinib nor doxycycline-induced knockdown of BMSC/IL-6- induced JunB upregulation in TetshJunB/MM.1S cells reduced Brd4/c-Myc mRNA/protein levels. Importantly, the activity of MZ-1 and trametinib was predicted by Brd4 and JunB expression levels using mathematical models, respectively. Further, combination of MZ-1 with trametinib or JunB knockdown synergistically inhibited tumor cell proliferation, and induced cell death in a 2D and a dynamic 3D model of the MM-BM milieu. Finally, our in vitro and ex vivo results were confirmed in vivo, utilizing BMSC:TetshJunB/MM.1S vs. BMSC:TetshSCR/MM.1S-carrying NSG mice treated with MZ-1 with/without doxycycline or trametinib.CONCLUSIONIn summary, our data demonstrate for the first time the existence of non-overlapping cMyc and JunB-regulated TF programs providing a rationale for combined cMyc:JunB targeting treatment strategies in MM. DisclosuresVallet: Pfizer: Honoraria; MSD: Honoraria; Roche Pharmaceuticals: Consultancy. Podar: Celgene: Consultancy, Honoraria; Roche Pharmaceuticals: Research Funding; Janssen Pharmaceuticals: Consultancy, Honoraria; Amgen Inc.: Consultancy, Honoraria.

Trajectory Optimization of CAVs in Freeway Work Zone considering Car-Following Behaviors Using Online Multiagent Reinforcement Learning

Work zone areas are frequent congested sections considered as the freeway bottleneck. Connected and autonomous vehicle (CAV) trajectory optimization can improve the operating efficiency in bottleneck areas by harmonizing vehicles’ manipulations. This study presents a joint trajectory optimization of cooperative lane changing, merging, and car-following actions for CAV control at a local merging point together with upstream points. The multiagent reinforcement learning (MARL) method is applied in this system, with one agent providing a merging advisory service at the merging point and controlling the inner-lane vehicles’ headway for smooth outer-lane vehicle merging, while other agents provide lane-changing advisory services at advance lane-changing points to control how vehicles make lane changes in advance and perform corresponding headway adjustment, similar to and jointly with the merging advisory service. Uniting all agents, the coordination graph (CG) method is applied to seek the global optimum, overcoming the exponential growth problem in MARL. Using MATLAB and the VISSIM COM interface, an online simulation platform is established. The simulation results show that MARL is effective for online computation with in-timing response. More importantly, comparisons of the results obtained in various scenarios demonstrate that the proposed system obtained smoother vehicle trajectories in all controlled sections, rather than only in the merging area, indicating that it can achieve better traffic conditions in freeway work zone areas.

Time Evolution of a System of Particles Obeying Coulomb’s Law and the High-speed Rollover of Suprathermal Tails in the Solar Wind

Abstract In this article, we show through a series of rigorous mathematical steps, starting with Liouville’s equation and solving it for the case of two protons using the method of characteristics, that a velocity distribution function, f(u), is formed that exhibits a power law, f ∝ u γ , where γ is −9/2, and an exponential-type rollover at large speeds, providing a potential explanation for the observations of suprathermal ions in the solar wind. The solution is valid for all times and all background conditions, though the power law does at some point merge with the core of the distribution. When it does so, a final distribution is found that agrees with overall energy conservation. Analytical approximations to the solution are discussed, along with explanations for the various phases that the solution undergoes.

Aircraft Sequencing and Scheduling in Parallel-Point Merge Systems for Multiple Parallel Runways

The Point Merge System (PMS) is one of the approaches that offer systematic sequencing in terminal maneuver area (TMA) which was developed at the EUROCONTROL Experimental Centre in 2006. The Parallel-Point Merge System (P-PMS) is used in TMAs with high air traffic density as a combination of two PMSs with opposite directions. However, it is difficult to optimize arrival sequences in such a system because of the additional separation requirements at common points as well as at merge points. Additionally, it is important to operate at maximum efficiency with parallel runway systems when using the runway reassignment process. Reassigning arriving/departing aircraft to a different runway, however, can significantly affect delays and fuel consumption depending on the difference in taxi-in/out times. This effect is overlooked in most aircraft sequencing and scheduling optimization studies with PMS. This study proposes single and multi-objective programming models for a TMA with P-PMS to minimize total fuel consumption, total flight time, and total delay including taxi-in/out times. The models were implemented on the current layout of Istanbul Airport having two PMS with two merge points, three common points, and five parallel runways. The considered traffic scenarios included both dependent and independent runway operations for mixed arrival–departure sequences. The results revealed that arrival–departure sequencing considering taxi-in/out times resulted in shorter delays up to 77.5% and low level of fuel consumption up to 8.7%.

OAB-030: Combined targeting of distinct c-Myc and JunB transcriptional programs induces synergistic anti-myeloma activity

<h3>Background</h3> Transcription factors (TF) are convergence points of signaling cascades that coordinate cell differentiation, proliferation and survival and are commonly deregulated in cancer, including multiple myeloma (MM). They contribute to the initiation of MM, promote tumor cell growth and drug resistance. Both cMyc, a merging point of the PI3K-, and JunB, a merging point of the MEK/MAPK signaling pathway, play pivotal roles in MM pathogenesis. Exciting novel approaches to inhibit TFs like proteolysis-targeting-chimera (PROTAC) promise to lead to selective tumor cell death with little consequence for normal cells. However, redundancy phenomena of TF-programs are likely to challenge their efficacy. Here, we report our final results on the combined targeting of distinct cMyc and JunB transcriptional programs. <h3>Methods</h3> Following CRISPR-loss-of-function screens for cMyc and JunB across MM cell lines and correlation analyses in MM patient datasets, the functional relevance of Brd4/cMyc- and MEK/JunB-induced TF programs was delineated using genomic and pharmacological approaches in 2D and 3D models of the BM microenvironment. Specifically, effects of single or combined targeting of cMyc- and JunB-induced transcriptional programs were analyzed by FACS, WB, qPCR and luciferase assays. In vitro and ex vivo results were finally verified in a MM xenograft mouse model. <h3>Results</h3> While CRISPR-loss-of-function screens of MM cell lines confirmed the dependency on cMyc and JunB, we did not observe correlative expression levels among these TFs, neither in the publicly available GSE6477 nor in the CoMMpass dataset. In contrast, a significant positive correlation was observed between MEK and JunB, and Brd4 and cMyc expression levels, respectively. The existence of two distinct Brd4/cMyc and MEK/JunB transcriptional programs in MM cells was supported by stable cMyc levels and resultant transcriptional activity upon JunB knockdown, and vice versa. Likewise, MZ-1, a novel PROTAC which targets Brd4, resulted in inhibition of BMSC/IL-6-induced cMyc but not JunB-upregulation. Conversely, neither the MEK inhibitor trametinib nor doxycycline-induced knockdown of BMSC/IL-6-triggered JunB upregulation in TetshJunB/MM.1S cells reduced Brd4/cMyc mRNA/protein levels. Importantly, the activity of MZ-1 and trametinib was predicted by Brd4 and JunB expression levels using mathematical scoring models, respectively. Moreover, combinations of MZ-1 with trametinib or JunB knockdown synergistically inhibited tumor cell proliferation and induced cell death in a 2D and a dynamic 3D model of the MM-BM milieu. Finally, our results were verified in BMSC:TetshJunB/MM.1S vs BMSC:TetshSCR/MM.1S-carrying NSG mice treated with MZ-1 with/without doxycycline or trametinib. <h3>Conclusions</h3> In summary, our data demonstrate for the first time the existence of non-overlapping cMyc and JunB-regulated transcriptional programs providing the rationale for combined cMyc:JunB targeting strategies for MM therapy.

Klein tunneling of semi-Dirac-like fermions in graphene

In this work, the Klein tunneling of semi-Dirac-like fermions confined in a single-layer graphene under uniaxial strain is studied. We consider the universal Hamiltonian to obtain the analytical solution for the transmission probability through a two-dimensional electrostatic barrier in the strongly strained graphene at the so-called merging point. In this regard, the numerical results of the transmission probability for several values of the merging parameter are presented. We demonstrate that the barrier would be completely transparent on the normal incidence for all values of the merging parameter. Finally, we turn our attention to obtain the exact solution of the transmission probability for a potential step to better illustrate it.

Analytical and Numerical Bifurcation Analysis of Circuits Based on Nonlinear Resonators

This work presents new frequency-domain methods for the analysis and simulation of circuits based on a nonlinear resonator, with operation ranges delimited by turning points. Insightful analytical conditions fulfilled at these turning points are derived, which will enable an identification of the effect of each circuit element on their location in the solution curve. The cusp points, or co-dimension two bifurcations at which two turning points merge into one, thus delimiting the multivalued intervals, are directly calculated for the first time to our knowledge. In addition, a new numerical method, compatible with the use of commercial harmonic balance, is presented for the straightforward tracing of the multivalued solution curves, together with a new procedure to determine the locus of turning points in terms of any two analysis parameters. This relies on the use of a new mathematical condition to obtain a surface of turning points in the space defined by the two parameters and the input power. The methods have been applied to a wireless power-transfer system based on a recently proposed configuration, obtaining very good agreement with the experimental results.

Impact of Online Promoting Techniques on Moving Forward the Status of Businesses within the covid-19 Circumstance: Ghana as the Merging Point.

The expanding improvement of data innovation and communication has delivered a wide impact on commerce processes. The Web has made it conceivable to reach universal markets as the foremost successful means of electronic showcasing or marketing with worldwide scope. Be that as it may, in Ghana, numerous companies were ignorant of the need of utilizing different showcasing and online promoting strategies and their impacts on companies' circumstances until basic circumstances such as this so-called pandemic. This article looks at the definitions and standards of showcasing and online deals, e-commerce, their pros and cons to thrust companies and teach to utilize this kind of marketing and business. This ponder demonstrates that this sort of promoting and exchange as a vital and competitive advantage has contributed altogether to deals development and expanded the share of the inner and outside market share to Ghanaian companies within the competitive age. With the expanding world competition and the predominance of the Coronavirus, get to worldwide markets has gotten to be more complicated, and the require for modern worldwide devices and strategies can be of incredible offer assistance in this respect. The shrewd utilize of e-commerce innovation can offer assistance Ghanaian companies move forward exchange proficiency, make more dynamic cooperation within the worldwide exchange field and offer assistance fortify the country’s position on territorial and worldwide markets.

Visuality 2021: Media and Communication

The article provides a synopsis of the issues discussed in the 6th international scientific conference Visuality 2021: Media and Communication. The background for the discussions was the tranformations of ways to communicate, also incrusted with the up-todate reflection on the influence of lockdown under COVID-19. The effects of the novel mediated communication on politics, education and art were discussed from different angles. Some presenters focused on the opening of new oppurtunities, others were worried about the disapperance of reality and authenticity. The possibility of visuality to communicate the most abstract scientific and philosophical ideas was also discussed, and visuality proved to be a merging point of many streams of human being in the world. In addition to most up-to-date challenges, the discussion also encompassed a broad historical perspective, down to the Rennaissance.

The evaluation of Istanbul airspace design from the perspective of complexity and safety

The approach, descent, and climb phases of flights in terminal maneuvering areas (TMAs) are some of the critical parts of a flight in which more than half of accidents happen. For an ANSP (Air Navigation Service Provider), to fulfill the responsibility with a high-quality service degree while maintaining safety, these difficult areas should be designed carefully and equipped with the most efficient procedures. Point merge system (PMS), which is defined as a systemized method for sequencing arrival flows, is launched in Istanbul's new TMA (LTFM TMA) being designed by DHMI (Devlet Hava Meydanları Isletmesi) to improve safety and efficiency. In this paper, the airspace complexity is based on adjusted density and structural index, and safety indicators. To investigate the effects of the radical changes made in re-organized LTFM TMA on the safety issue in comparison with the previous terminal maneuvering area, LTBA TMA, six months' data consisting of 75215 arrival and departure flights are used. Results reflect that the LTFM TMA, one of the world's busiest terminal airspaces, has statistically significantly lower scores in terms of conflict numbers per aircraft, complexity metrics, adjusted density, the hour of interactions, and flight hours than LTBA TMA. Lastly, there exists no longer a significant relationship between conflict types and complexity after launching the new design and structure.

Editorial: Introducing the IMPACT Journal and its First Issue

Welcome to this, the first issue of the International Modern Perspectives on Academia and Community Today (IMPACT) Journal. In creating this Journal and producing this first issue we have proven that multidisciplinary working is possible. Moreover, we have shown that as academics, we have the power to challenge the norms and work in innovative ways within the contexts of our institutions. Thinking and working in innovative ways reflects on our practices as we reimagine our work and role in working with the community. Through the creation of a multidisciplinary Journal, we intend to provide a platform that will not only host approaches used in various disciplines but will also act as a merging point by putting forward perspectives from the communities alongside academic work. In doing so, we hope to promote new forms of dialogue, which have the potential to generate new research directions, and help cement the notion that academia and community are intertwined rather than separate entities within the social relations. The purpose of academic practice is to serve the needs of the community as both members of the community and academics who adopt an advocacy standpoint. Therefore, we hope that through the collaborative working practices underpinning this initiative we can achieve our aim to promote community involvement and engagement and meaningful contribution in the short and long term.