Mercury Intake Research Articles

Public health risk of mercury in China through consumption of vegetables, a modelling study

Sample measurement of mercury (Hg) contents is a common method for health risk assessment of Hg through vegetable consumption in China. In the present work, we undertook the first modelling study which produced consistent health-risk maps for the whole eastern China. Regional maps of Probable Daily Intake (PDI) of Total mercury (THg) and Methylmercury (MeHg) over the studied area were produced, which were important for the researchers and policy-makers to evaluate the risk and to propose mitigation measures if necessary. The model predictions of air-borne Hg(0) concentrations agreed well with the observations and simulated Hg distribution over China as reported elsewhere. Our calculated PDIs of THg in vegetables were also comparable to those reported in the literature. There was 19% of the studied area with PDIs > 0.08µgkg−1 bw d−1 [half of the reference dose (RfD)]. The PDI for THg (MeHg) varied from 0.034 (0.007) to 0.162 (0.035)µgkg−1 bw d−1 with an average of 0.058 (0.013)µgkg−1 bw d−1. The highest calculated PDIs of THg over China was equal to the RfD, while the calculated PDIs of MeHg were well below the RfD of 0.1µgkg−1 bw d−1. The health risk was of concern through consumption of THg in leafy vegetables, rice/wheat and fish in Liaoning Provinces, Hunan, Zhejiang and Guizhou Provinces, with the associated PDIs exceeding the RfD. Despite this, the heath risk of MeHg exposure for the general population in southern China from the same foodstuff consumption was not a concern. The contribution of consumption through leafy vegetation should be considered when THg and MeHg exposures to the population are evaluated. The results improve our understanding in managing public health risk in China especially in large cities with high population, and thus have important contribution to enhance sustainable urbanization as one of the principle goals under the framework of the Nature-Based Solution (NBS).

Intentional ingestion of elemental mercury requiring multi-step decontamination and prophylactic appendectomy: a case report and treatment proposal

Background: Ingestion of elemental mercury (Hg0) is considered non-toxic. After massive ingestion, local intestinal complications may develop: retention within appendix is quite frequent but treatment is debated. We describe a case of intentional ingestion of Hg0 requiring multi-step decontamination and prophylactic appendectomy.Case detail: A 19-year-old woman was admitted to ED for abdominal pain. History revealed ingestion of large amount of Hg0 as suicide attempt. To prevent absorption, facilitate elimination, and avoid complications a conservative approach was started. Due to inefficacy of initial maneuvers colonoscopy with irrigation/aspiration was performed, repeated whole bowel irrigation was continued and second colonoscopy was performed to clean residual metal. Abdominal plain films confirmed the presence of retained mercury within the appendix in asymptomatic patient. To reduce risk of appendicitis, potential perforation, and possibly systemic toxicity, a prophylactic laparoscopic appendectomy was performed at day 5 with removal of all retained mercury without peritoneal spillage. Highest mercury concentration was 22.7 mcg/L in serum (1-4.5 mcg/L) and 5.1 mcg/L in urine (0.1–5 mcg/L).Conclusions: After ingestion, metal retention in appendix is quite frequent. Evidence about optimal treatment are different and based on case reports. A multi-step approach with multidisciplinary evaluation tailored to the patient is suggested.

Evaluation of the Dietary Intake of Cadmium, Lead and Mercury and Its Relationship with Bone Health among Postmenopausal Women in Spain.

Background: Heavy metals, such as lead, cadmium, and mercury, are absorbed through contaminated food sources and water. Few studies have investigated the extent to which dietary heavy metals are associated with low bone mineral density. Aims: We aimed to characterize the dietary intake of the heavy metals lead, cadmium and mercury among healthy, non-smoking postmenopausal women in Spain. Furthermore, we sought to establish a putative relationship between bone health and the intake of these heavy metals in this population. Study Design: The daily intake of the heavy metals considered for the different food groups was calculated by accounting for food content and consumption in 281 postmenopausal women. Bone measurements were performed using a Quantitative Bone Ultrasound (QUS), a Dual-Energy X-ray Absorptiometry (DXA) and a Peripheral Quantitative Computed Tomography (pQCT). Results: The average estimated dietary cadmium exposure among the 281 women studied was 29.87 μg/day (20.41–41.04) and 3.03 μg/kg body weight (b.w.; 2.17–4.40). Dietary lead exposure was 46.24 μg/day (38.11–54.77) and 4.87 μg/kg b.w. (4.00–6.14). The estimated dietary mercury exposure was 11.64 μg/day and 1.19 μg/kg b.w. (0.82–1.76). Participants were classified according to their heavy metal intake (above or below the respective medians). After further adjustment for potential confounding factors, no significant differences were found in all the measured parameters (p > 0.05). Conclusions: We did not find associations between bone health and the dietary intake of three heavy metals in postmenopausal women. Dietary intake of the measured heavy metals were within the recommended values.

Mercury pollution in vegetables, grains and soils from areas surrounding coal-fired power plants

Mercury contamination in food can pose serious health risks to consumers and coal-fired power plants have been identified as the major source of mercury emissions. To assess the current state of mercury pollution in food crops grown near coal-fired power plants, we measured the total mercury concentration in vegetables and grain crops collected from farms located near two coal-fired power plants. We found that 79% of vegetable samples and 67% of grain samples exceeded the PTWI’s food safety standards. The mercury concentrations of soil samples were negatively correlated with distances from the studied coal-fired power plants, and the mercury contents in lettuce, amaranth, water spinach, cowpea and rice samples were correlated with the mercury contents in soil samples, respectively. Also, the mercury concentrations in vegetable leaves were much higher than those in roots and the mercury content of vegetable leaves decreased significantly after water rinses. Our calculation suggests that probable weekly intake of mercury for local residents, assuming all of their vegetables and grains are from their own farmland, may exceed the toxicologically tolerable values allowed, and therefore long-term consumptions of these contaminated vegetables and grains may pose serious health risks.

Arsenic, cadmium, mercury, sodium, and potassium concentrations in common foods and estimated daily intake of the population in Valdivia (Chile) using a total diet study

This study was designed to estimate the dietary intake of total arsenic, inorganic arsenic, cadmium, mercury, sodium, and potassium by the general adult population (aged 18–65) of Valdivia, Chile. Calculations were based on a 24-h dietary recall survey. The highest dietary intake of t-As (73.0 μg/day), i-As (20.0 μg/day), Cd (18.0 μg/day), Hg (5.8 μg/day), Na+ (3112.8 mg/day), and K+ (2077.5 mg/day) were for 70-kg adults.Estimating carcinogenic risk (CR > 4 × 10−4) due to exposure to i-As indicated that consumers remain at low risk for cancer. The cumulative health risk was evaluated by summing the target hazard quotient of cadmium (0.26) mercury (0.27) and inorganic arsenic (0.96); this calculation allows us to express the total target hazard quotient as 1.50 where a value > 1 indicates that there is a potential health risk for the population. Total intake of Cd and Hg were therefore within the limits estimated as being safe whereas Na+ and K+ intake for the Valdivia population did not follow the recommended values established by the World Health Organization (WHO). The Na+ intake exceeded the daily recommended intake while K+ intake was lower than the daily recommended intake. This indicates a health risk for the Valdivia population.

Mercury content in whey protein and potential risk for human health

This study investigated total Mercury (THg) contamination in whey protein and was performed to monitor the exposure of the Brazilian population to THg contamination in nineteen brands of whey protein with different formulation and estimate the potential health risks of mercury exposure to humans through whey protein consumption. Results indicated that the highest Hg concentration level was 9.41±0.295ngg−1, while the lowest Hg level was 0.548±0.029ngg−1. These concentrations were below the maximum limit for food products. However, there is no World Community regulation regarding mercury contamination on dairy products. The risk to human health concerning Hg ingestion was calculated based on consumption data in Brazil and has indicated that potential health risks related to exposure to total mercury from whey protein ingestion need more attention from researchers and more studies are needed, especially including specific intake of mercury from other food products that are included in a balanced diet.

Total mercury levels in commercial fish species from Italian fishery and aquaculture

ABSTRACTTotal mercury levels were measured in 42 commercial fish species caught off the Central Adriatic and Tyrrhenian coasts of Italy and in 6 aquaculture species. The study on wild fish covered species differing in living habitat and trophic level. The study on farmed fish covered marine and freshwater species from intensive and extensive aquaculture and their feed. Mercury levels were analysed by thermal decomposition–amalgamation–atomic absorption spectrophotometry. Total mercury concentrations in the muscle of wild fish showed a high variability among species (0.025–2.20 mg kg−1 wet weight). The lowest levels were detected in low trophic-level demersal and pelagic–neritic fish and in young individuals of high trophic-level species. Levels exceeding the European Commission limits were found in large-size specimens of high trophic-level pelagic and demersal species. Fish from intensive farming showed low levels of total mercury (0.008–0.251 mg kg−1). Fish from extensive rearing showed variable contamination levels, depending on the area of provenience. An estimation of the human intake of mercury associated to the consumption of the studied fish and its comparison with the tolerable weekly intake is provided.

Assessment of Mercury Intake from Fish Meals Based on Intervention Research in the Polish Subpopulation

The paper’s objective was to estimate weekly Hg intake from fish meals based on intervention research. Total Hg (THg) concentrations in blood and hair samples collected from men (n = 67) from an intervention study as well as muscular tissues of fresh and after heat-treating fish were determined using the thermal decomposition amalgamation atomic absorption spectrometry method (TDA-AAS) using direct mercury analyzer (DMA-80). The mean of the estimated weekly intake (EWI) was estimated at 0.62 μg/kg bw/week in the range 0.36–0.96 μg/kg body weight (bw) /week through the consumption of 4 edible marine fish species every day (for 10 days) by the participants from the intervention research in Lodz, Poland. The Hg intake in the volunteers in our intervention study accounted for 38.6% of the provisional tolerable weekly intake (PTWI) (1.6 μg/kg bw, weekly) value. The average Hg concentration in the analyzed fish ranged from 0.018 ± 0.006 mg/kg wet weight (Gadus chalcogrammus) to 0.105 ± 0.015 mg/kg wet weight (Macruronus magellanicus). The results for the average consumers were within PTWI of methylmercury (MeHg). Moreover, the average concentration of Hg in the selected fish after heat treatment did not exceed the maximum permitted concentrations for MeHg (MPCs = 0.5 mg/kg wet weight) in food set by the European Commission Regulation (EC/1881/2006). Hence, the risk of adverse effects of MeHg for the participants is substantially low.

Probabilistic risk analysis of mercury intake via food consumption in Spain

In Spain, recently, the public institutions have given information to the population in relation to fish consumption and the risk that it poses to health from the ingestion of mercury supposedly contained in the fish. At the same time, several scientific societies have published various works in this direction. All this without there being, up to now, any study on the evaluation of a probabilistic risk from mercury due to fish and seafood intake in Spain, which is the objective of this present work. For that purpose, we took individual data from a survey of the total diet of 3000 people, whose consumption of the principal fish and seafood species (49) was estimated. We compiled individualized data (2000) on the total mercury content of those species, which were completed and validated with bibliographic statistical data.After estimating the distributions of each fish and seafood species, both of their consumption and their mercury content, a simulation was made of the distribution of mercury ingestion from fish and seafood offered by 2.6% of the Spanish population at risk of exceeding total mercury recommendations, and between 12.2% and 21.2% of those exceeding methylmercury ones. The main species responsible were tuna fish, swordfish and hake, and significant differences were identified in fish consumption between sexes and ages, although, in the risk percentage, what stands out is an increase in the latter with an increase in age.

Human biological monitoring of mercury for exposure assessment

Mercury (Hg) is a naturally occurring element that has metallic, inorganic and organic forms, each with their own implications for human health. Exposure to mercury primarily occurs by inhalation of metallic mercury vapors and by dietary intake of organic mercury. Early health effects are often not well detected. Therefore, determination of the internal dose is a valuable approach in primary prevention. With this review, we aim to give an overview of the different human biological monitoring (HBM) approaches for short- and long-term exposure to different chemical forms of mercury. We performed a literature search in PubMed using Medical Subject Headings (MeSH) terms as well as free text words. From 417 reviews found, we selected 8 reviews. In addition, online information from national and international health authorities was used. The format of the biological application datasheets from the BIOMONECS project was used to provide an overview of the different biological media for HBM of mercury and methyl mercury. Recent exposure to metallic mercury can be assessed by blood sampling within 24 h after exposure. If children are involved, breath sampling can be considered as a less invasive alternative. Urinary mercury levels mainly reflect long-term inhalation exposure to elemental mercury vapors and divalent mercury. Mercury in blood and hair reflects mid- and long-term exposure to methyl mercury, whereas analysis of a hair segment close to the scalp indicates recent exposure. A flow chart was developed to support the selection of the most suitable HBM approach. For each of the different biological matrices, we provided an overview of advantages and limitations. Depending on the source and duration of exposure, blood, exhaled air, urine or hair can be used for mercury exposure assessment.

Sampling of total mercury in sand on Sydney beaches and assessment of risk of exposure to children

Accumulation of anthropogenic mercury (Hg) onto coastal environments is potentially putting children playing in these areas, particularly beaches, at risk of exposure to mercury through the ingestion of sand. Samples were collected along 11 of Sydney's beaches and two Newcastle beaches where children may be exposed and analysed using a Direct Mercury Analyser (DMA-80). Risk of exposure was assessed based on Health Canada's exposure threshold for the ingestion of total mercury of 105ng Hg kg-1 BW d-1 and USEPA published values of daily ingestion rates by children (0.2g soil d-1 and 1.75g soil d-1). Concentrations of total mercury in beach sand ranged from 0.0035 to 57.89µg kg-1. Beaches with the highest Hg concentration were found to be located in close proximity to potential mercury sources. The highest daily intake calculated was 7.132ng Hg kg-1 BW d-1, well below the daily intake threshold, indicating children have a minimal exposure risk.

Sampling of total mercury in sand on Sydney beaches and assessment of risk of exposure to children

Accumulation of anthropogenic mercury (Hg) onto coastal environments is potentially putting children playing in these areas, particularly beaches, at risk of exposure to mercury through the ingestion of sand. Samples were collected along 11 of Sydney's beaches and two Newcastle beaches where children may be exposed and analysed using a Direct Mercury Analyser (DMA-80). Risk of exposure was assessed based on Health Canada's exposure threshold for the ingestion of total mercury of 105ng Hg kg-1 BW d-1 and USEPA published values of daily ingestion rates by children (0.2g soil d-1 and 1.75g soil d-1). Concentrations of total mercury in beach sand ranged from 0.0035 to 57.89µg kg-1. Beaches with the highest Hg concentration were found to be located in close proximity to potential mercury sources. The highest daily intake calculated was 7.132ng Hg kg-1 BW d-1, well below the daily intake threshold, indicating children have a minimal exposure risk.

Prehod kovin iz tal v tkiva izbranih vrst prostoživečih živali

We studied transfer of metals from soil to tissues of selected free-living animals: small mammals (Myodes glareolus, Microtus arvalis, Apodemus flavicollis), Parus major and red fox (Vulpes vulpes), inhabiting Veliki Vrh, Slovenia. At the same time, we assessed the risk for these organisms on the basis of comparison with metal levels in plant and animal tissues to effect concentrations for liver, critical levels of metals, defined in Slovene legislation and Hazard Quotient calculation. The exception was Parus major. This passerine bird was replaced with Turdus merula which feeds on earthworms. Our results show that meadow and forest ecosystems at Veliki Vrh, which was exposed (especially in the past) to high levels of pollutants (including metals) from thermal power plant, are moderately polluted with Pb (forest soil, animal tissues), Hg (forest soil, animal tissues) and Cd (meadow soil, roots of grass and clovers). Nevertheless, the risk for selected free-living animals was in general insignificant, since the levels of Hg, Pb and Cd were below critical (small mammals, red fox) and lethal levels (earthworms). However, there is a probability of risk due to the intake of mercury in red fox through Myodes glareolus and of Pb in Turdus merula through earthworms, if these food sources would constitute at least half of the diet of these organisms.

Relating food and human hair to assess mercury exposure levels in Poboya, Central Sulawesi, Indonesia

Poboya is a major small-scale gold-mining area in Central Sulawesi, Indonesia, that has been operating since 2009. About 200–500 kg of mercury is released each day as a result of gold-mining activities over a total area of 7000 ha. We examined mercury contamination by using two types of sample, namely food and human hair. Samples were obtained in Poboya and in the city of Palu, 11 km away. Samples of 22 foods were obtained from traditional markets in Poboya and Palu. Total mercury concentrations ranged from 0.003 to 0.31 µg/g in foods from Poboya and from 0.001 to 0.13 µg/g in those from Palu. The highest total mercury concentration in Poboya was found in unripe banana, which is frequently consumed by the local people. In Poboya, the weekly mercury intakes from foods were calculated at 180.3 µg/person from vegetables, 1.7 µg/person from processed foods, 51.4 µg/person from seafood, and 17.2 µg/person from meat and eggs. In Palu, the weekly mercury intakes were 2.9 µg/person from vegetables, 3.1 µg/person from processed foods, 60.8 µg/person from seafood, and 19 µg/person from meat and eggs. These findings delineated Poboya as an area polluted by mercury contamination. Intake of mercury-contaminated food influenced the results obtained in human hair. Hair concentrations of total mercury in Poboya ranged from 0.3 to 19.6 µg/g.

Mercury accumulation in marine fish most favoured by Malaysian women, the predictors and the potential health risk.

We identified marine fish species most preferred by women at reproductive age in Selangor, Malaysia, mercury concentrations in the fish muscles, factors predicting mercury accumulation and the potential health risk. Nineteen most preferred marine fish species were purchased (n=175) from selected fisherman's and wholesale market. Length, weight, habitat, feeding habit and trophic level were recognised. Edible muscles were filleted, dried at 80°C, ground on an agate mortar and digested in Multiwave 3000 using HNO3 and H2O2. Total mercury was quantified using VP90 cold vapour system with N2 carrier gas. Certified reference material DORM-4 was used to validate the results. Fish species were classified as demersal (7) and pelagic (12) or predators (11), zoo benthos (6) and planktivorous (2). Length, weight and trophic level ranged from 10.5 to 75.0cm, 0.01 to 2.50kg and 2.5 to 4.5, respectively. Geometric mean of total mercury ranged from 0.21 to 0.50mg/kg; maximum in golden snapper (0.90mg/kg). Only 9% of the samples exceeded the JECFA recommendation. Multiple linear regression found demersal, high trophic (≥4.0) and heavier fishes to accumulate more mercury in muscles (R 2=27.3%), controlling for all other factors. About 47% of the fish samples contributed to mercury intake above the provisional tolerable level (45μg/day). While only a small portion exceeded the JECFA fish Hg guideline, the concentration reported may be alarming for heavy consumers. Attention should be given in risk management to avoid demersal and high trophic fish, predominantly heavier ones.

Mini-review: toxicity of mercury as a consequence of enzyme alteration.

Mercury, in both its elemental and bonded states, is noted for its negative effects on biological organisms. Recent anthropogenic and environmental disasters have spurred numerous comparative studies. These studies attempted to detail the biochemical implications of mercury ingestion, in low, persistent concentrations as well as elevated acute dosages. The studies propose models for mercuric action on healthy cells; which is centered on the element's disruption of key enzymatic processes at deposition sites. Mercury's high affinity for the sulfhydryl moieties of enzyme catalytic sites is a common motif for enzyme inactivation. These permanent covalent modifications inactivate the enzyme, thereby inducing devastating effects on an organism's metabolic functions. Mercury has been shown to be highly nonspecific in its binding to sulfhydryl moieties, and highly varied in terms of how it is encountered by living organisms. This review focuses on mercury's effects on a wide swath of enzymes, with emphasis on how these alterations deleteriously affect several metabolic pathways.

Association of Dietary Intake and Biomarker Levels of Arsenic, Cadmium, Lead, and Mercury among Asian Populations in the United States: NHANES 2011-2012.

Background:We have recently shown that biomarker levels of selected metals are higher in Asians than in other U.S. ethnic groups, with important differences within selected Asian subgroups. Much of this difference may be dietary in origin; however, this is not well established.Objective:We evaluated dietary intake of toxic metals as a source of increased biomarker levels of metals among U.S. Asians.Methods:We estimated daily food consumption and dietary intake of arsenic, cadmium, lead, and mercury by combining 24-hr dietary intake recall data from the 2011–2012 National Health and Nutrition Examination Survey (NHANES) with data from the USDA Food Composition Intake Database and FDA Total Dietary Study. We analyzed associations between dietary metal intake and biomarker levels of the metals using linear regression. Further, estimated food consumption and metal intake levels were compared between Asians and other racial/ethnic groups (white, black, Mexican American, and other Hispanic) and within three Asian subgroups (Chinese, Indian Asian, and other Asians).Results:Significant associations (p < 0.05) were found between biomarker levels and estimated dietary metal intake for total and inorganic arsenic and mercury among Asians. Asians had the highest daily fish and rice consumption across the racial/ethnic groups. Fish was the major contributor to dietary mercury and total arsenic intake, whereas rice was the major contributor to inorganic arsenic dietary intake. Fish consumption across the Asian subgroups varied, with Asian Indians having lower fish consumption than the other Asian subgroups. Rice consumption was similar across the Asian subgroups.Conclusions:We confirmed that estimated dietary intake of arsenic (total and inorganic) and mercury is significantly associated with their corresponding biomarkers in U.S. Asians, using nationally representative data. In contrast, estimated dietary intake of cadmium and lead were not significantly associated with their corresponding biomarker levels in U.S. Asians.Citation:Awata H, Linder S, Mitchell LE, Delclos GL. 2017. Association of dietary intake and biomarker levels of arsenic, cadmium, lead, and mercury among Asian populations in the United States: NHANES 2011–2012. Environ Health Perspect 125:314–323; http://dx.doi.org/10.1289/EHP28

Assessment of Dietary Mercury Intake and Blood Mercury Levels in the Korean Population: Results from the Korean National Environmental Health Survey 2012-2014.

From a public health perspective, there is growing concern about dietary mercury intake as the most important source of mercury exposure. This study was performed to estimate dietary mercury exposure and to analyze the association between mercury intake and blood mercury levels in Koreans. The study subjects were 553 adults, comprising a 10% representative subsample of the Korean National Environmental Health Survey (KoNEHS) 2012–2014, who completed a health examination, a face-to-face interview, and a three-day food record. Dietary mercury and methylmercury intakes were assessed from the three-day food record, and blood mercury concentration was measured using a mercury analyzer. The association between dietary mercury intake and blood mercury levels was analyzed by comparing the odds ratios for the blood mercury levels above the Human BioMonitoring (HBM) I value (5 μg/L) among the three groups with different mercury intakes. The average total mercury intake was 4.74 and 3.07 μg/day in males and females, respectively. The food group that contributed most to mercury intake was fish and shellfish, accounting for 77.8% of total intake. The geometric mean of the blood mercury concentration significantly and linearly increased with the mercury and methylmercury intakes (p < 0.001). The odds ratios for blood mercury levels above the HBM I value in the highest mercury and methyl mercury intake group were 3.27 (95% Confidence Interval (CI) 1.79–5.95) and 3.20 (95% CI 1.77–5.79) times higher than that of the lowest intake group, respectively. Our results provide compelling evidence that blood mercury level has a strong positive association with dietary intake, and that fish and shellfish contribute most to the dietary mercury exposure.

Assessment of mercury intake based on intervention research in Polish subpopulation

Assessment of mercury intake based on intervention research in Polish subpopulation

Assessment of mercury intake via fish and fish products among children in Belgrade, Serbia: A pilot study

Assessment of mercury intake via fish and fish products among children in Belgrade, Serbia: A pilot study