Mental health is a state of mental well-being that enables people to cope with the stresses of life, realize their abilities, learn well and work well, and contribute to their community. India's mental health struggles are largely due to societal stigma and inadequate healthcare access. Depression is a major cause of disability worldwide and contributes greatly to the global disease burden. Depression is characterized by persistent sadness, hopelessness, irritability, guilt, loss of interest, fatigue, difficulty concentrating, sleep disturbances, changes in appetite, physical aches, and thoughts of death or suicide. Symptoms can also include increased anger, restlessness, withdrawal, impulsivity, alcohol or drug use, isolation, and difficulties with sexual desire and performance. Major depressive disorder (MDD) is one of the most common types of depression. It is characterized by changes in neuronal structure and function, which are accompanied by several biochemical changes. It is caused by a variety of biological, psychological, and environmental factors. This review will cover depression, its signs and symptoms, risk factors, mechanisms, and management. The management of depression includes various types of medication, therapies, counselling, stimulation, and strategies to combat depression.