Menopause-specific Quality Of Life Research Articles

Dose spouses’ coping skills promote qol and dyadic coping of menopausal women?

ABSTRACT Lack of menopausal knowledge damages the quality of life (QoL) and couples’ relationships. A new approach to prevent marital distress based upon stress and coping has introduced Couples Coping Enhancement Training (CCET). The present study assessed the effect of menopause care training using CCET approach on QoL and coping in menopausal women. This educational interventional study was conducted in 2019 on 80 postmenopausal women and their spouses. The couples were randomly selected from health care centers using the cluster random sampling method and were divided into control and intervention groups. Four training sessions were held for the intervention group. Data were collected using The Menopause-Specific Quality of Life (MENQOL) questionnaire, menopausal knowledge questionnaire, and Dyadic Coping Inventory (DCI) and were analyzed using independent Sample t-test, Paired Sample T-Test, and Structural Equation Modeling (SEM) in SPSS version 25 and Amos version 21 software. At the beginning of the study, there was no significant difference in menopausal knowledge, QoL, and dyadic coping between the two groups. However, the CCET approach significantly increased menopausal knowledge, coping in couples and women’s QoL in the intervention group compared to the control group. CCET can help couples to cope with menopausal symptoms more efficiently.

A study of mindfulness-based stress-reduction training effects on menopause-specific quality of life in postmenopausal women: A randomized controlled trial

ObjectivesPhysical and psychological changes in most postmenopausal women tend to lower their quality of life. Various medical/psychological interventions have been applied to improve the postmenopausal quality of life. This study set out to investigate the effect of Mindfulness Based Stress Reduction (MBSR) training on the Menopause-specific quality of life (MENQOL). MethodsThis RCT was conducted on 66 postmenopausal women aged 47–62 in Iran. Participants were randomly assigned to either the MBSR or the control group. The menopause--specific quality of life was assessed in two groups via MENQOL questionnaire prior to, immediately and three months after the intervention. ResultsThe findings revealed a significant improvements in MENQOL (P < 0.001),as well as physical(P = 0.001), psychosocial(P = 0.001) and sexual(P < 0.001)dimensions of the intervention groups compared to the control group, immediately and 3 months after the intervention. ConclusionMBSR program can be safely applied to improve menopausal women's quality of life and curb the postmenopausal symptoms. Trial registration numberIRCT2015072523344N1.

Traditional Korean medicine treatment for tamoxifen associated adverse events of breast cancer patient: A CARE – Compliant case report

BackgroundAdverse events of endocrine therapy reduce the breast cancer patient's quality of life and adversely affect treatment compliance. MethodA 50-year-old breast cancer patient complained of several symptoms such as hot flush, hyperhidrosis, urinary frequency, and depression. These symptoms occurred after taking tamoxifen. The adverse events induced by tamoxifen were assessed using both World Health Organization-Uppsala Monitoring Centre (WHO-UMC) causality categories and the Naranjo probability scale. Traditional Korean herbal medicine was used to treat vasomotor symptoms and vulvovaginal symptoms. And acupuncture was used to manage musculoskeletal symptoms. ResultsAs a result of traditional Korean medicine treatment for 25 days, symptoms and quality of life improved significantly, and improvement was estimated in the Menopause Rating Scale and Menopause-Specific Quality of Life. ConclusionThis case report suggests that traditional Korean medicine interventions might have improved the adverse events of tamoxifen in breast cancer patients.

The effect of nursing approaches applied according to Meleis’ Transition Theory on menopause-specific quality of life

This is a randomized controlled experimental study aimed to determine the effect of nursing approaches applied according to Meleis’ Transition Theory on menopause-specific quality of life. The study participants consisted of 64 women. A personal information form and the menopause-specific quality-of-life (MENQOL) questionnaire were used to collect data. The MENQOL pretest mean score was 4.61 ± 1.00 in the experimental group and 4.57 ± 1.18 in the control group; post-test scores were 3.88 ± 1.10 and 4.81 ± 1.10, respectively. The nursing approaches applied in this study significantly reduced the MENQOL scores of women in the experimental group.

Individual Characteristics Associated with Menopausal Symptom Severity and Menopause-Specific Quality of Life: A Rural Perspective.

This study aims to analyze the relationship/effect of a wide range of individual factors with/on menopausal symptom severity (MSS) and menopause-specific quality of life (MSQoL) in rural Turkish women. This cross-sectional study included rural perimenopausal/postmenopausal women. Demographic (age, marital status, and education and employment status), physical (body weight and height), medical (chronic disease status), obstetric (number of gravidas), and menopausal characteristics (menopausal nature, perception of menopause, and menopausal stage), physical activity level, anxiety and depressive symptom levels, MSS, and MSQoL of the participants were assessed. The relationships between MSS/MSQoL and all individual characteristics were examined by correlation analyses. In addition, MSS and MSQoL were compared between various categories using independent-groups t tests and variance analyses. Statistical significance level was set at p <0.05. A total of 245 women (mean age 56.64 ± 6.59 years) were included in the study. It was found that marital status, body mass index, presence of chronic disease, the number of gravidas, perception of menopause, and anxiety and depressive symptom levels were associated with MSS and MSQoL (p < 0.05). On the other hand, symptom severity and QoL did not change according to the level of education, employment status, menopausal nature, menopausal stage, and physical activity level (p > 0.05). MSS and MSQoL in rural women may be associated or affected by a wide range of individual characteristics, and this relationship or influence differs from the urban women literature at some points. Further studies are needed to illuminate the menopausal process in rural areas and compare rural and urban results.

The Effect of Jazar Supplement on Quality of Life and Sexual Function in Postmenopausal Women: A Double-Blind, Randomized, Placebo-Controlled Trial.

Background Menopause is one of the most critical stages of a woman's life and is accompanied by symptoms including hot flashes, night sweats, mood swings, sexual dysfunction, mucus atrophy, and vaginal dryness. Women tend to use complementary and alternative medicine such as herbs rather than hormone replacement therapy to alleviate these symptoms. The purpose of this study is to examine the effects of Jazar supplement (herbal supplement comprising Vitex, fennel, and carrot seeds) on sexual function, quality of life, and vaginal atrophy in postmenopausal women. Methods This study was a randomized clinical trial conducted on ninety postmenopausal women. Participants were randomized to intervention/control groups using block randomization. The intervention group received four Jazar capsules (500 mg each) daily, while the control group received a placebo for eight weeks. Data were gathered using a socio-demographic questionnaire, the Female Sexual Function Index (FSFI), and the Menopause-Specific Quality of Life (MENQOL) before the intervention and at weeks 4, 8, and 10. Vaginal pH and vaginal maturation index (VMI) were measured before and at the end of the study. Results Eighty-four women completed the trial, and six women withdrew. There were no remarkable differences between the two groups in terms of quality of life, sexual function, VMI, and vaginal pH at baseline. At the end of the study, participants in the intervention group had a significantly lower score in terms of quality of life (P < 0.001) and vaginal pH (P=0.001), and a higher FSFI (P < 0.001) and VMI (P=0.030) score compared to the control group. Conclusion Based on the findings of the present study on menopausal women, the Jazar supplement significantly improved quality of life and sexual function and prevented or delayed vaginal atrophy.

The Effectiveness of Melissa Officinalis L. versus Citalopram on Quality of Life of Menopausal Women with Sleep Disorder: A Randomized Double-Blind Clinical Trial.

The present study aimed to assess the effect of Melissa Officinalis L. (a combination of lemon balm with fennel fruit extract) compared with citalopram and placebo on the quality of life of postmenopausal women with sleep disturbance. The present study is a randomized, double-blind, placebo clinical trial among 60 postmenopausal women with sleep disturbance who were referred to a university hospital from 2017 to 2019. The participants were randomized to receive M. Officinalis L. (500 mg daily), citalopram (30 mg) or placebo once daily for 8 weeks. The Menopause-Specific Quality of Life (MENQOL) questionnaire was self-completed by each participant at baseline and after 8 weeks of the intervention and was compared between groups. The mean for all MENQOL domain scores were significantly improved in the M. Officinalis L. group compared with citalopram and placebo (p < 0.001). The mean ± standard deviation (SD) after 8 weeks in the M. Officinalis L., citalopram and placebo groups was 2.2 ± 0.84 versus 0.56 ± 0.58 versus 0.36 ± 0.55 in the vasomotor (p < 0.001), 1.02 ± 0.6 versus 0.28 ± 0.2 versus 0.17 ± 0.1 in the psychomotor-social (p < 0.001), 0.76 ± 0.4 versus 0.25 ± 0.1 versus 0.11 ± 0.1 in the physical and 2.3 ± 1.0 versus 0.35 ± 0.5 versus 0.41 ± 0.5 in the sexual domain, respectively. The results revealed that M. Officinalis L. may be recommended for improving the quality of life of menopausal women with sleep disturbance. The present study was registered by the name "Comparison of the efficacy of citalopram and compound of Asperugo procumbens and foeniculum vulgare in treatment of menopausal disorders" with the code IRCT2013072714174N1 in the Iranian Registry of Clinical Trials (IRCT).

Menopause-Specific Quality of Life of Rural Women.

Background:Menopause is a natural process, but it causes hormonal and biological changes in the body, which can result in drastic effects on quality of life (QOL) of women.Objective:The study was conducted to assess the menopause-specific QOL (MENQOL) of rural women.Subjects and Methods:A descriptive cross-sectional design was used to assess MENQOL of rural women of the selected villages of Punjab. A total of 150 menopausal women were selected using simple random sampling technique. The MENQOL questionnaire was administered to assess the QOL in relation to menopausal symptoms.Results:The mean score of overall QOL was 3.4274 ± 0.99, which revealed a moderate impact of menopausal symptoms on the QOL. Stepwise linear regression revealed the significant impact of 16 out of 29 menopausal symptoms on QOL. Furthermore, MENQOL was found to be significantly associated with education, marital status, and sleep pattern of women.Conclusions:There is a significant effect of menopausal symptoms on QOL of women which emphasizes the need to create awareness among menopausal women regarding menopausal symptoms and management to improve their QOL.

Menopause-Related Quality of Life among Urban Women of Hyderabad, India.

Background:Menopause is regarded as the marker for various symptoms such as physical, psychological, vasomotor, and sexual impairing the quality of life (QOL).Objectives:To assess the menopause-related QOL and determine associated factors among postmenopausal women.Materials and Methods:A cross-sectional study was conducted among 378 postmenopausal women attending the obstetrics and gynecology department of a tertiary care hospital using a standardized menopause-specific QOL (MENQOL) questionnaire consisting of physical, vasomotor, psychosocial, and sexual domains.Results:The study included 378 women aged above 40 years, with majority belonging to the age group of 46–50 years. The total MENQOL mean score was found to be 19.35 ± 16.20, with physical domain score the highest 14.89 ± 11.85, followed by vasomotor 1.98 ± 3.83, psychosocial 1.82 ± 3.29, and the least as sexual domain with score of 0.624 ± 2.21. Post menopausal women with age less than 50 years, No formal education, High socio-economic status, Home makers and duration of menopause less than 5 years was found to have statistical significant association with higher vasomotor domain score; No formal education, higher socio economic status and duration of menopause with greater than 5 years was found to be significant with higher sexual domain scores.Conclusions:Menopause may be associated with a decrease in QOL. Certain sociodemographic variables showed a statistically significant association with the vasomotor and sexual domains. Awareness and interventions that affect the modifiable factors may help in increasing the QOL at menopause.

The Effect of Mindfulness on Quality of Life among Women with Premature Ovarian Insufficiency: A Randomized Clinical Trial.

Background:Premature ovarian insufficiency may impair the quality of life and expose women to disorders such as cardiovascular disease, osteoporosis, and depression. This study aimed to evaluate the effect of mindfulness on the quality of life in women with premature ovarian insufficiency.Methods:This study involved 62 women who were randomly allocated into two groups of mindfulness and control. The mindfulness group received eight sessions of training. A demographic questionnaire, menopause-specific quality of life and a checklist (for assessing hot flashes) were used to collect the data. The quality of life, frequency, and intensity of hot flashes were measured before the intervention, immediately, and 3 months after it. Independent t-test, the Chi-square test, and the repeated measure test were used for data analysis.Results:The scores of quality of life dropped from 95.6 ± 9.77 at baseline to 77.32 ± 7.93 after intervention and 48.32 ± 4.96 at 3-months follow-up in the mindfulness group but rose from 99.5 ± 16.1 at baseline to 100.2 ± 15.33 after intervention, and 102.6 ± 14.9 3-months after it in the control group, P < 0.001. The scores of vasomotor, psychological, physical, and sexual domains also improved significantly in the mindfulness group compared to the control group. The mean of hot flashes in the mindfulness group was 1.30 ± 0.69 and decreased to 1.1 ± 0.56 and 0.66 ± 0.58 immediately and in 3 months after intervention, respectively. The frequency of hot flashes was 14.74 ± 10.4 per week before intervention in the mindfulness group which reduced to 12.38 ± 8.66 and 6.74 ± 6.34 per week, immediately and 3 months after the intervention, while in the control group, there was an increase in the frequency of hot flashes (P < 0.0001).Conclusion:According to the results of this study, mindfulness could improve quality of life and reduce hot flashes, so mindfulness training for women with premature ovarian insufficiency is strongly recommended.

Consensus-based translation, cultural adaptation, and validation of the Menopause Specific Quality of Life Questionnaire for menopausal women in Sri Lanka

Introduction: Quality of life during menopause could be affected by distressing menopausal symptoms. Menopause Specific Quality of Life Questionnaire (MENQOL) is an instrument developed to measure menopausal symptoms and their associated degree of bother. Objectives: To translate, culturally adapt and validate the Menopause Specific Quality of Life Questionnaire (MENQOL) for menopausal women of 45-55 years in Sri Lanka Methods: Translation, cultural adaptation, and validation of 29 items in MENQOL were carried out in three stages. The first stage involved translation of English version of the questionnaire into Sinhala language using a consensus-based nominal group process by a panel of five experts. In the second stage, cultural adaptation of the translated MENQOL questionnaire was carried out by conducting qualitative interviews with ten post-menopausal women of 45-55 years. In the third stage, construct validity of MENQOL was assessed in a community-based cross-sectional survey conducted among 174 postmenopausal women in 45-55 age group. Results: At the end of the translation process, the panel of experts agreed on the most appropriate translations through a voting process (consensus measurement), and appropriate translations were chosen by resolving disagreements (consensus development). The translated questionnaire named as MENQOLS was further modified based on inputs from the interviews with post-menopausal women. Principal component analysis of the validation study data resulted in a 26-item, five factor structure for MENQOL-S. Conclusions: MENQOL-S is conceptually and culturally appropriate for use in Sri Lanka. It could be used in community or healthcare settings to assess menopause specific quality of life among menopausal women and to assess outcome during intervention studies to improve their quality of life.

Exercise and Quality of Life in Women with Menopausal Symptoms: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Menopausal symptoms are associated with deterioration in physical, mental, and sexual health, lowering women’s quality of life (QoL). Our study objective is to examine the effect of exercise on QoL in women with menopausal symptoms. After initially identifying 1306 studies published on PubMed, Web of Science, Scopus, and Cochrane Library before June 2020, two researchers independently selected nine randomized controlled trials (RCTs) in which any type of exercise was compared with no active treatment. We assessed the risk of bias in the included studies using the Cochrane risk-of-bias 2.0 tool for RCTs and computed the converged standardized mean difference with a 95% confidence interval. We found evidences for the positive effects of exercise on physical and psychological QoL scores in women with menopausal symptoms. However, there was no evidence for the effects of exercise on general, social, and menopause-specific QoL scores. The most common interventions for women with menopausal and urinary symptoms were yoga and pelvic floor muscle training (PFMT), respectively. In our meta-analyses, while yoga significantly improved physical QoL, its effects on general, psychological, sexual, and vasomotor symptoms QoL scores as well as the effect of PFMT on general QoL were not significant. Our findings suggest that well-designed studies are needed to confirm the effect of exercise on QoL in women with menopausal symptoms.

Efficacy of Labisia pumila and Eurycoma longifolia standardised extracts on hot flushes, quality of life, hormone and lipid profile of peri-menopausal and menopausal women: a randomised, placebo-controlled study.

BackgroundInterest in herbal medicines and non-hormonal therapies for the treatment of menopausal symptoms has increased since the publication of adverse effects of estrogen replacement therapy. Vasomotor symptoms are the most characteristic and notable symptoms of menopause.ObjectiveTo investigate the changes in the frequency and severity of hot flush and associated vasomotor symptoms experienced by peri-menopausal and menopausal women supplemented with the herbal formulation (Nu-femme™) comprising Labisia pumila (SLP+®) and Eurycoma longifolia (Physta®) or placebo.DesignRandomised, double-blind, placebo-controlled, 24-week study enrolled 119 healthy women aged 41–55 years experiencing peri-menopausal or menopausal symptoms and supplemented with Nu-femme™ or placebo. The primary endpoint was comparative changes between treatment groups in the change in the frequency and severity of hot flushes. The secondary objectives were to assess the changes in the frequency and severity of joint pain, Menopause Rating Scale (MRS) and Menopause-Specific Quality of Life (MENQOL) questionnaire domain scores. Concentrations of serum hormone, lipid profile, bone markers, sleep quality and vitality were also studied as secondary objectives.ResultsAt week 12, significant (P < 0.01) improvements in hot flush symptoms were observed in Nu-femme™ and placebo groups. Even though there was no significant difference between groups, higher percentage of improvement, 65%, was seen in Nu-femme™ compared to 60% in placebo. Significant improvements (P < 0.001) in MRS and MENQOL scores at weeks 12 and 24 were observed in both groups, respectively. Luteinising hormone and follicle-stimulating hormone levels were significantly reduced (P < 0.05) at weeks 12 and 24, respectively, compared to baseline in the Nu-femme™ group, with no significant changes observed in the placebo group. There were significant (P < 0.05) reductions in serum low-density lipid and triglycerides levels at week 12 in Nu-femme™ group, but no changes seen in placebo group. At the end of week 24, changes in haematology and clinical chemistry parameters remained within normal clinical ranges in both groups.ConclusionHerbal formulation consists of L. pumila and E. longifolia (Nu-femme™) may support reduction in hot flushes and improvements in hormone and lipid profile in healthy peri-menopausal and menopausal women.

Impact of body mass index (BMI) and physical activities among menopausal women

Background: The impact of body mass index (BMI) and physical activity on menopausal symptoms is still unclear. The relationship between menopausal symptoms with physical activity and BMI may differ depending on the specific symptom and socio-demographic factors may have impact on the symptoms.&#x0D; Objectives: It was aimed to determine most common presenting symptoms as per MRS scale, and to assess physical activity status as per IPAQ scale. Also to assess the impact of physical activity and BMI on common menopausal symptoms in addition to socio-demographic characteristics of the respondents in particular.&#x0D; Methods: This was a descriptive cross-sectional study among menopausal women age between 45-60 years attended at Outpatient Department (OPD) of Obs &amp; Gynae in three randomly selected tertiary care hospital of the country during November 2017 to April 2018. The data were generated as per Menopause Rating Scale (MRS) and by International Physical Activity Questionnaire (IPAQ) and by calculation of Body Mass Index (BMI).&#x0D; Results: About 70.0% respondents were within 45-54 years of age group, 28.0% respondents were illiterate and 78.0% were housewife. Overweight was to be found almost 30.0% within 50-54 years age group. Respondent’s somato-vegetative menopausal symptoms like hot flashes, heart discomfort and sleeping problems were found mild to moderate among 53.0-67.0% respondents mostly. Psychological and urogenital menopausal symptoms were found mild to moderate among 52-62.0% and 45-53.0% respondents respectively. The irritability and heart discomfort were found significantly associated with age. Moreover, joint and muscular discomfort, hot flushes, sweating and heart discomfort were also found significantly associated with BMI (p&lt;.05).&#x0D; Conclusion: Findings of the study will help planners and policy makers in developing one stop comprehensive services as appropriate in minimizing symptoms without medications and will also help minimizing burden of symptoms among menopausal women towards a comfortable end stage life line towards menopause specific quality of life (MENQOL).&#x0D; Bangladesh Med Res Counc Bull 2020; 46(2): 109-114

Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women.

Menopause is an inevitable developmental event that women encounter at an age of 42–54 years. The drop of estrogen levels that accompanies cessation of menstruation is associated with multiple vasomotor, physical, neuropsychological, and sexual symptoms, which may hamper quality of life. This study aimed to examine the severity of psychological symptoms and their correlates among peri- and postmenopausal Emirati women (N = 60, mean age = 54.88 ± 6 years). Participants were interviewed using the Menopause-Specific Quality of Life (MENQOL) and attitudes toward menopause scale (ATMS). In four path analysis models, vasomotor symptoms, weight gain, and fatigue had significant direct effects on symptoms of anxiety, depression (only weight gain and fatigue), and psychological distress. Fatigue significantly mediated the effects of vasomotor symptoms and weight gain on symptoms of anxiety, depression (only vasomotor symptoms), psychological distress, and memory problems. These models explained 47.6%, 44.5%, 56.6%, and 29.1% of the variances in anxiety, depression, psychological distress, and memory problems, respectively. Participants with more severe menopausal symptoms expressed more negative attitudes toward menopause though regression analysis revealed that only vasomotor symptoms could significantly contribute to ATMS scores. In conclusion, psychological distress is widespread among menopausal women, and it is associated with vasomotor symptoms, fatigue, and change of body composition (obesity). Psychological symptoms, along with vasomotor symptoms, express a key link to negative attitudes toward menopause. Therefore, interventional strategies that target psychological distress may promote coping with midlife transition and improve mental health among menopausal women.

Association of Menopausal Symptoms with Body Composition Pattern and Body Mass Index Across Menopausal Age Among Mongolian Women

Objectives: To investigate the correlation of body fat distribution pattern and body mass index (BMI) on the prevalence and clinical manifestation of menopausal symptoms across the menopausal stage among Mongolian women. Methods: A survey was conducted amongst a total of 1084 women aged 40-65 years Ulaanbaatar city and selected provinces representing five main remote regions of Mongolia. A questionnaire was used to collect demographic and socioeconomic data. Menopause related characteristics were evaluated using the Menopause-specific Quality of Life (MENQOL) questionnaire. Further, measurements were recorded to determine waist-to-hip-ratio and body mass index (BMI). Pearson's Chi-Square test was used to correlate. Results: Using the waist-to-hip-ratio, 84.4% of participants had the android type, and 15.6% were of the gynoid type. As for BMI, 38.4% were overweight, and 28.8% were obese. In multiple regression analysis, BMI had significant relationships with psychosocial and sexual problems (p&lt;0.05). Moreover, BMI and menopause status were independent risk factors for the development of cardiovascular disease. Postmenopausal obese and overweight women were 1.6 times more likely to have cardiovascular disease than women in the perimenopausal status (p&lt;0.05). Conclusions: Overweight and obese perimenopausal women have a lower quality of life due to the prevalence of sexual and psychosocial symptoms. Obese postmenopausal Mongolian women are at significantly higher risk of developing cardiovascular disease.

Quality of life of postmenopausal women of Kaski district

Aim: To assess menopause specific quality of life of postmenopausal women.&#x0D; Method: This descriptive survey was carried out among postmenopausal women aged 40 to 60 years residing in a municipality of Kaski district of Nepal. Data was collected from 150 women meeting the criteria through face to face interview using a structured questionnaire consisting of socio-demographic items and Menopause-Specific Quality of Life (MENQOL) scale.&#x0D; Results: Respondents’ mean age and SD was 52.83±4.19 years and their mean menopausal age and SD was 47.12±4.34 years. The most common menopausal symptom reported by the respondents was decrease in physical strength (82.70%) and the least frequent symptom was increase in facial hair (7.40%). The mean scores and SD of MENQOL for physical, psychosocial, sexual and vasomotor domains were 1.67±0.42, 1.46±0.42, 1.31±0.47 and 1.27±0.57 respectively. Significant differences were detected in vasomotor, psychosocial and physical domain score according to physical activity, living status and body mass index respectively (p=0.05).&#x0D; Conclusions: Based on findings, it is concluded that all the postmenopausal women tend to have at least one or more menopausal symptoms. Physical domain is the most affected domain of QOL among the postmenopausal women. The presence of menopausal symptoms affects the quality of life of women adversely that warrants focused teaching and counselling.&#x0D; Keywords: menopause, menopausal symptoms and menopause specific quality of life

Investigating the Relationship between Menopause Specific Quality of Life and Perceived Social Support among Postmenopausal Women in Iran

ABSTRACT Background The purpose of this research was to investigate the relationship between Menopause Specific Quality of Life (MENQOL), Perceived Social Support (PSS) and factors associated with MENQOL among a group of Iranian Postmenopausal women in 2018. Methods In this cross-sectional study 410 of Postmenopausal Iranian women in Neyshabur are examined. QOL was assessed using MENQOL questionnaire, and social support was assessed through administration of a modified Sarason’s Social Support Questionnaire. The data were analyzed through conduction of a Pearson correlation coefficient and Linear regression analysis using SPSS software package 20. Results It was found that the average age of PMW was 53.92 ± 3.86 years. The total scores of the QOL ranged from 10 to 30, with a mean of 37.83 (SD = 12.9). Mean scores of Sexual, psychological, physical, and Vasomotor domain of QOL were 12.55 ± 6.96, 14.66 ± 2.20, 18.11 ± 1.85, 12.02 ± 4.93. Perceived social support was positively correlated with the overall QOL (r = 0.68; P ≤ 0.001). Moreover, perceived social support was associated with Vasomotor (r = .55, p ≤ .001), Psychosocial (r = .65, p ≤.001), Physical (r = .59, p ≤ .001), Sexual (r = .48, p ≤ .001) subscales of QOL. Conclusions The results of the current study showed a significant relationship between perceived social support and QOL in PMW. Further research is suggested to investigate other variables among PMW in Iran.

752-P: Effects of Diabetes and Menopause on Mood, Quality of Life, and A1C

Women with type 1 (T1D) and type 2 diabetes (T2D) are living longer than any other time in history. Little is known about the effects of diabetes and the menopause transition on psychosocial outcomes at mid-life. We conducted a cross-sectional survey to evaluate the emotional and behavioral correlates of menopause in women ≥ age 40 with and without diabetes (ND). 655 women completed an online survey querying demographics, A1c, diabetes distress (DDS), depressive symptoms (PHQ-8), health-related quality of life (HRQOL; SF-12), Menopause Specific Quality of Life (MenQOL), and Pittsburgh Sleep Quality Index (PSQI). Mean age was 53 years, 83% self-identified as White, 52% married, &amp;gt;30% had a college degree and household income ≥$100,000/year. 55% (n=366) of had ND, 27% (n=181) T2D, 9% (n=60) TID and 7% (n=46) prediabetes. 6% (n=43) were premenopausal, 25% (n=167) perimenopausal and 67% (n=440) in menopause. Mean A1c in women with diabetes was higher in perimenopausal (7.8%) compared to menopausal women (7.1%, p=0.04). Depressive symptom levels were higher in T2D compared to ND (M=9.2 vs. 5.5, p&amp;lt;0.05). DDS was not different in T1D vs. T2D. T2D had lower HRQOL for both SF-12 mental (M=46.0 vs. 48.6, p=.004) and physical components (PCS; M=40.6 vs. 48.3, p&amp;lt;.05) compared to ND. T2D also had lower SF-12 PCS as compared to T1D (M=40.6 vs. 50.2) and prediabetes (M=40.6 vs. 42.7, all p&amp;lt;0.05). T2D reported worse subjective sleep quality (M=1.5 vs. 1.2) and more use of sleep medication (M=1.1 vs. 0.8) compared to ND. They also reported worse sleep disturbance (M=1.6) than T1D (M=1.3) and ND (M=1.3; all p&amp;lt;.05). MenQOL physical domain was worse in T2D (M=4.1) than T1D (M=3.6) and ND (M=3.1, p&amp;lt;0.05). Psychosocial (M=3.9 vs. 2.9), vasomotor (M=3.8 vs. 2.8) and sexual (M=3.6 vs. 2.6) functioning were worse in T2D compared to ND (p&amp;lt;0.05). T2D women had greater psychological and physical distress affecting HRQOL than T1D and ND across the menopause transition. Glycemic management appears to be more difficult in perimenopause than later in the menopause transition. Disclosure H. Sharma: None. B.A. Myers: None. M. de Groot: Consultant; Self; Kenner Family Foundation, Inc., LifeScan Diabetes Institute.

Concomitants of menopause-specific quality of life in premenopausal and post-menopausal women living in South Korea

ABSTRACT The present study investigated the concomitants of menopause-specific quality of life among premenopausal and postmenopausal women. Based on the Wilson and Cleary model of quality of life, this cross-sectional study recruited 329 women of age 40–65 years following operational convenience. The study was conducted in the office of the Korea Population, Health and Welfare Association (KPHWA) in Incheon, South Korea. Data collected on sociodemographic characteristics, social support, biological/physiological characteristics, the Pittsburgh Sleep Quality Index (PSQI-K), and self-rated health. Menopause-specific quality of life questionnaire (MENQOL) was used in this study. Hierarchical multiple linear regression analysis was performed. The study found that social support and self-rated health were negatively correlated with MENQOL in premenopausal women, while the income level and self-rated health were negatively associated with MENQOL in postmenopausal women. Sleep quality was positively correlated with MENQOL in both premenopausal and postmenopausal women. The study results indicate the need for tailored approaches based on menopausal status. Especially, social support may help improve the MENQOL of premenopausal women, while in postmenopausal women, improved sleep quality may enhance their menopause-specific quality of life.