752-P: Effects of Diabetes and Menopause on Mood, Quality of Life, and A1C

Abstract

Women with type 1 (T1D) and type 2 diabetes (T2D) are living longer than any other time in history. Little is known about the effects of diabetes and the menopause transition on psychosocial outcomes at mid-life. We conducted a cross-sectional survey to evaluate the emotional and behavioral correlates of menopause in women ≥ age 40 with and without diabetes (ND). 655 women completed an online survey querying demographics, A1c, diabetes distress (DDS), depressive symptoms (PHQ-8), health-related quality of life (HRQOL; SF-12), Menopause Specific Quality of Life (MenQOL), and Pittsburgh Sleep Quality Index (PSQI). Mean age was 53 years, 83% self-identified as White, 52% married, >30% had a college degree and household income ≥$100,000/year. 55% (n=366) of had ND, 27% (n=181) T2D, 9% (n=60) TID and 7% (n=46) prediabetes. 6% (n=43) were premenopausal, 25% (n=167) perimenopausal and 67% (n=440) in menopause. Mean A1c in women with diabetes was higher in perimenopausal (7.8%) compared to menopausal women (7.1%, p=0.04). Depressive symptom levels were higher in T2D compared to ND (M=9.2 vs. 5.5, p<0.05). DDS was not different in T1D vs. T2D. T2D had lower HRQOL for both SF-12 mental (M=46.0 vs. 48.6, p=.004) and physical components (PCS; M=40.6 vs. 48.3, p<.05) compared to ND. T2D also had lower SF-12 PCS as compared to T1D (M=40.6 vs. 50.2) and prediabetes (M=40.6 vs. 42.7, all p<0.05). T2D reported worse subjective sleep quality (M=1.5 vs. 1.2) and more use of sleep medication (M=1.1 vs. 0.8) compared to ND. They also reported worse sleep disturbance (M=1.6) than T1D (M=1.3) and ND (M=1.3; all p<.05). MenQOL physical domain was worse in T2D (M=4.1) than T1D (M=3.6) and ND (M=3.1, p<0.05). Psychosocial (M=3.9 vs. 2.9), vasomotor (M=3.8 vs. 2.8) and sexual (M=3.6 vs. 2.6) functioning were worse in T2D compared to ND (p<0.05). T2D women had greater psychological and physical distress affecting HRQOL than T1D and ND across the menopause transition. Glycemic management appears to be more difficult in perimenopause than later in the menopause transition. Disclosure H. Sharma: None. B.A. Myers: None. M. de Groot: Consultant; Self; Kenner Family Foundation, Inc., LifeScan Diabetes Institute.