TPACK is a framework that integrates technological knowledge, pedagogical knowledge, and content knowledge in a learning context. This article discusses the analysis of the TPACK framework in the application of the ISLE-based STEM approach for the case of mass-spring oscillations. The successful application of the ISLE-based STEM approach model in learning activities must start from increasing the TPACK ability. However, TPACK and ISLE-based STEM information are currently still limited, so it is necessary to conduct a study to analyze the TPACK relationship through the development of ISLE-based STEM learning instruments. This research was conducted based on the development of learning media, namely a prototype of spring vibrations using MEMS and IoT technology as well as student worksheets designed with an ISLE-based STEM approach model by the STEM Research Center of Universitas Syiah Kuala. The analysis results show that the application of TPACK through the ISLE-based STEM model approach requires a complex process. This information is a step in the development and assessment of ISLE-based STEM learning media on the TPACK framework to strengthen 21st-century skills.
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