Compact low-power devices with ultrafast processing speed are the fundamental building blocks for the development of the state-of-the-art logic systems and memristor prominently fulfills these demands and plays a major role in digital circuit design. In this work, design, implementation, and performance evaluation of memristor-based logic gates, such as NOT, AND, NAND, OR, NOR, XOR, and XNOR, and combinational logic circuits, such as adder, subtractor, and 2 <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\times$</tex-math> </inline-formula> 1 mux, are presented via SPECTRE in Cadence Virtuoso. Herein, we propose an optimized design of memristor-based logic gates and combinational logic circuits and draw a comparative analysis with the conventional 180-nm complementary metal–oxide–semiconductor (CMOS) technology. The utilized memristor model is thoroughly validated with the experimental results of a high-density Y <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$_{\text{2}}$</tex-math> </inline-formula> O <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$_{\text{3}}$</tex-math> </inline-formula> -based memristive crossbar array (MCA), which shows a significantly low values of coefficient of variabilities in device-to-device (D2D) and cycle-to-cycle (C2C) operation. The area, power, and delay calculated from these combinational circuits are found to be reduced by more than 71.4%, 40%, and 54%, respectively, as compared to the conventional 180-nm CMOS technology. The impact of multiple CMOS technology nodes (90 and 180 nm) on the power consumption at the chip-level logic circuit implementation has also been investigated. The adopted memristor-based design significantly improves the performance of various logic designs, which makes it area and power efficient and enables a major breakthrough in designing various low-power, low-cost, ultrafast, and compact circuits.