Recognition Memory Task Research Articles

Remembering visual and linguistic common ground in shared history.

Successful communication requires speakers and listeners to refer to information in their common ground. Shared history is one of the bases for common ground, as information from a communicative episode in the past can be referred to in future communication. However, to draw upon shared history, communicative partners need to have an accurate memory record that they can refer to. The memory mechanism for shared history is poorly understood. The current study investigated the ways in which memory for shared history is prioritised. Two experiments presented a referential communication task followed by a surprise recognition memory task, with the former task serving as an episode of shared history. Experiment 1 revealed superior memory for information that was both seen in the communicators' common ground and referred to, followed by information that was seen but not referred to, and finally by information privileged to the participants. Experiment 2 provided a replication of Experiment 1 and further demonstrated that these co-presence effects are not dependent on the presence of a speaker with a different perspective to the participant.

The role of morphology in novel word learning: a registered report.

The majority of the new words that we learn every day as adults are morphologically complex; yet, we do not know much about the role of morphology in novel word learning. In this study, we tackle this issue by comparing the learning of: (i) suffixed novel words (e.g. flibness); (ii) novel words that end in non-morphological, but frequent letter chunks (e.g. fliban); and (iii) novel words with non-morphological, low-frequency endings (e.g. flibov). Words are learned incidentally through sentence reading, while the participants' eye movements are monitored. We show that morphology has a facilitatory role compared with the other two types of novel words, both during learning and in a post-learning recognition memory task. We also showed that participants attributed meaning to word parts (if flibness is a state of happiness, then flib must mean happy), but this process was not specifically triggered by the presence of a suffix (flib must also mean happy in fliban and flibov), thus suggesting that the brain tends to assume similar meanings for similar words and word parts.

The late positive event-related potential component is time locked to the decision in recognition memory tasks

Two event-related potential (ERP) components are commonly observed in recognition memory tasks: the Frontal Negativity (FN400) and the Late Positive Component (LPC). These components are widely interpreted as neural correlates of familiarity and recollection, respectively. However, the interpretation of LPC effects is complicated by inconsistent results regarding the timing of ERP amplitude differences. There are also mixed findings regarding how LPC amplitudes covary with decision confidence. Critically, LPC effects have almost always been measured using fixed time windows relative to memory probe stimulus onset, yet it has not been determined whether LPC effects are time locked to the stimulus or the recognition memory decision. To investigate this, we analysed a large (n = 132) existing dataset recorded during recognition memory tasks with old/new decisions followed by post-decisional confidence ratings. We used ERP deconvolution to disentangle contributions to LPC effects (defined as differences between hits and correct rejections) that were time locked to either the stimulus or the vocal old/new response. We identified a left-lateralised parietal LPC effect that was time locked to the vocal response rather than probe stimulus onset. We also isolated a response-locked, midline parietal ERP correlate of confidence that influenced measures of LPC amplitudes at left parietal electrodes. Our findings demonstrate that, contrary to widespread assumptions, the LPC effect is time locked to the recognition memory decision and is best measured using response-locked ERPs. By extension, differences in response time distributions across conditions of interest may lead to substantial measurement biases when analysing stimulus-locked ERPs. Our findings highlight important confounding factors that further complicate the interpretation of existing stimulus-locked LPC effects as neural correlates of recollection. We recommend that future studies adopt our analytic approach to better isolate LPC effects and their sensitivity to manipulations in recognition memory tasks.

Chemogenetic activation or inhibition of histaminergic neurons bidirectionally modulates recognition memory formation and retrieval in male and female mice.

Several lines of evidence demonstrate that the brain histaminergic system is fundamental for cognitive processes and the expression of memories. Here, we investigated the effect of acute silencing or activation of histaminergic neurons in the hypothalamic tuberomamillary nucleus (TMNHA neurons) in vivo in both sexes in an attempt to provide direct and causal evidence of the necessary role of these neurons in recognition memory formation and retrieval. To this end, we compared the performance of mice in two non-aversive and non-rewarded memory tests, the social and object recognition memory tasks, which are known to recruit different brain circuitries. To directly establish the impact of inactivation or activation of TMNHA neurons, we examined the effect of specific chemogenetic manipulations during the formation (acquisition/consolidation) or retrieval of recognition memories. We consistently found that acute chemogenetic silencing of TMNHA neurons disrupts the formation or retrieval of both social and object recognition memory in males and females. Conversely, acute chemogenetic activation of TMNHA neurons during training or retrieval extended social memory in both sexes and object memory in a sex-specific fashion. These results suggest that the formation or retrieval of recognition memory requires the tonic activity of histaminergic neurons and strengthen the concept that boosting the brain histaminergic system can promote the retrieval of apparently lost memories.

Intergenerational Transmission of Social Anxiety: The Role of Parents’ Fear of Negative Child Evaluation and Their Self-Referent and Child-Referent Interpretation Biases

Abstract Purpose Parents’ fear of negative evaluation (FNE), fear of negative child evaluation (FNCE; parents’ fear that their child is evaluated negatively by others), and self- and child-referent negative interpretation biases have been proposed to play a role in the intergenerational transmission of social anxiety. In this cross-sectional study, we tested whether parents’ self-reported FNE and self-referent interpretation bias, as well as their FNCE and child-referent interpretation bias, statistically mediated the relationship between parent social anxiety and parent-reported child social anxiety. Methods A total of 179 parents of 13–16-year-old adolescents completed questionnaires concerning own social anxiety, their FNE, and FNCE and their child’s social anxiety. Parents’ self- and child-referent interpretation biases were measured using scenario completion and memory recognition tasks. Results Parents’ FNCE partially statistically mediated the relationship between parent and child social anxiety. Parents’ FNE and their self- and child-referent interpretation biases did, however, not statistically mediate this relationship. Conclusions Parents’ FNCE does, but their FNE and self- and child-referent interpretation biases do not seem to play a role in the intergenerational transmission of social anxiety. Hence, parents’ FNCE might be a promising target for clinical practice while designing therapies and interventions concerning child social anxiety.

Increased flexibility of CA3 memory representations following environmental enrichment

Environmental enrichment (EE) improves memory, particularly the ability to discriminate similar past experiences.1,2,3,4,5,6 The hippocampus supports this ability via pattern separation, the encoding of similar events using dissimilar memory representations.7 This is carried out in the dentate gyrus (DG) and CA3 subfields.8,9,10,11,12 Upregulation of adult neurogenesis in the DG improves memory through enhanced pattern separation.1,2,3,4,5,6,11,13,14,15,16 Adult-born granule cells (abGCs) in DG are suggested to contribute to pattern separation by driving inhibition in regions such as CA3,13,14,15,16,17,18 leading to sparser, nonoverlapping representations of similar events (although a role for abGCs in driving excitation in the hippocampus has also been reported16). Place cells in the hippocampus contribute to pattern separation by remapping to spatial and contextual alterations to the environment.19,20,21,22,23,24,25,26,27 How spatial responses in CA3 are affected by EE and input from increased numbers of abGCs in DG is, however, unknown. Here, we investigate the neural mechanisms facilitating improved memory following EE using associative recognition memory tasks that model the automatic and integrative nature of episodic memory. We find that EE-dependent improvements in difficult discriminations are related to increased neurogenesis and sparser memory representations across the hippocampus. Additionally, we report for the first time that EE changes how CA3 place cells discriminate similar contexts. CA3 place cells of enriched rats show greater spatial tuning, increased firing rates, and enhanced remapping to contextual changes. These findings point to more precise and flexible CA3 memory representations in enriched rats, which provides a putative mechanism for EE-dependent improvements in fine memory discrimination.

Memory enhancement for emotional words is attributed to both valence and arousal

We do not memorize items in our surroundings with equal priority. Previous literature has widely shown that emotional stimuli are better remembered than neutral stimuli. However, given emotional stimuli and neutral stimuli often differ in both valence and arousal dimensions, it remains unclear whether the enhancement effects can be attributed to valence, or just to arousal. Importantly, most prior studies relied on a relatively small number of stimuli and non-emotional factors such as word length, imageability and other confounds were hard to control. To address these challenges, we analyzed multiple large databases of recognition memory and free recall tasks from previous research by items with many lexical and semantic covariates included, examining the effects of valence or arousal when controlling for each other. Our results showed a U-shaped relationship between valence and memory performance for both recognition and free recall, and a linear relationship between arousal and memory performance for both tasks. These findings showed that the memory enhancement effects can be attributed to both valence and arousal. We demonstrated these effects with generalizability across many stimuli and controlled for non-emotional factors. Together, these findings disentangle the contribution of valence and arousal in emotional memory enhancement effects and provide insights for current major theories of emotional memory.

Post-hypnotic suggestion improves confidence and speed of memory access with long-lasting effects

In our study, we use the post-hypnotic suggestion of easy remembering to improve memory with long-lasting effects. We tested 24 highly suggestible participants in an online study. Participants learned word lists and recalled them later in a recognition memory task. At the beginning of the study, participants were hypnotized and the post-hypnotic suggestion to remember easily was associated with a cue that participants used during the recognition memory task. In a control condition, the same participants used a neutral cue. One week later, participants repeated both conditions with new word lists.Participants were significantly faster and more confident in their recognition ratings in the easy-remembering condition compared to the control condition, and this effect persisted over one week. Crucially, the increased speed and confidence in the easy-remembering condition did not affect memory accuracy. That makes our hypnosis intervention promising for patients experiencing subjective memory impairments. APA PsycINFO codes2343 (Learning and Memory), 2380 (Consciousness States), 3351 (Clinical Hypnosis)

Age-Differential Role of Gaze Reinstatement in Recognition Memory for Negative Visual Stimuli.

Although research has shown that the replay of encoding-specific gaze patterns during retrieval, known as gaze reinstatement, facilitates memory retrieval, little is known about whether it differentially associates with the negativity preference in memory (defined as enhanced memory for negative stimuli relative to neutral stimuli in this study) among younger and older adults. The present study aims to address this research gap. A total of 33 older adults (16 women; aged 58-69 years, M = 63.48, SD = 2.98) and 36 younger adults (10 women; aged 18-26 years, M = 20.39, SD = 1.57) completed a remember/know recognition memory task involving negative and neutral pictures. Their eye movements were tracked during both the memory encoding and retrieval phases. Younger and older adults had better memory for negative than neutral pictures. Older adults exhibited significantly stronger gaze reinstatement for negative than neutral stimuli, while this difference was nonsignificant in younger adults. Moreover, gaze reinstatement is positively linked to memory performance in both age groups. The results suggest that gaze reinstatement may play age-differential roles in the negativity preference of memory. Negative valence may enhance gaze reinstatement, which improves subsequent recognition memory, particularly among older adults. The finding contributes to a better understanding of the mechanisms underlying the negative preference for memory in different age groups.

Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in vascular dementia rat and improved recognition memory

This study aimed to investigate structural synaptic plasticity in the medial prefrontal cortex of rats under treadmill exercise pretreatment or naive conditions in a vascular dementia model, followed by recognition memory performance in a novel object recognition task. In this study, 24 Sprague–Dawley rats were obtained and randomly assigned into 4 groups as follows: control group (Con group, n = 6), vascular dementia (VD group, n = 6), exercise and vascular dementia group (Exe + VD group, n = 6), and exercise group (Exe group, n = 6). Initially, 4 weeks of treadmill exercise intervention was administered to the rats in the Exe + VD and Exe groups. Then, to establish the vascular dementia model, the rats both in the VD and Exe + VD groups were subjected to bilateral common carotids arteries surgery. One week later, open-field task and novel recognition memory task were adopted to evaluate anxiety-like behavior and recognition memory in each group. Then, immunofluorescence and Golgi staining were used to evaluate neuronal number and spine density in the rat medial prefrontal cortex. Transmission electron microscopy was used to observe the synaptic ultrastructure. Finally, microdialysis coupled with high-performance liquid chromatography was used to assess the levels of 5-HT and dopamine in the medial prefrontal cortex. The behavior results showed that 4 weeks of treadmill exercise pretreatment significantly alleviated recognition memory impairment and anxiety-like behavior in VD rats (P < 0.01), while the rats in VD group exhibited impaired recognition memory and anxiety-like behavior when compared with the Con group (P < 0.001). Additionally, NeuN immunostaining results revealed a significant decrease of NeuN-marked neuron in the VD group compared to Con group (P < 0.01), but a significantly increase in this molecular marker was found in the Exe + VD group compared to the Con group (P < 0.01). Golgi staining results showed that the medial prefrontal cortex neurons in the VD group displayed fewer dendritic spines than those in the Con group (P < 0.01), and there were more spines on the dendrites of medial prefrontal cortex cells in Exe + VD rats than in VD rats (P < 0.01). Transmission electron microscopy further revealed that there was a significant reduction of synapses intensity in the medial prefrontal cortex of rats in the VD group when compared with the Con group(P < 0.01), but physical exercise was found to significantly increased synapses intensity in the VD model (P < 0.01). Lastly, the levels of dopamine and 5-HT in the medial prefrontal cortex of rats in the VD group was significantly lower compared to the Con group (P < 0.01), and treadmill exercise was shown to significantly increased the levels of dopamine and 5-HT in the VD rats (P < 0.05). Treadmill exercise pretreatment ameliorated structural synaptic plasticity impairments of medial prefrontal cortex in VD rat and improved recognition memory.

Identification of Early Hippocampal Dynamics during Recognition Memory with Independent Component Analysis.

The hippocampus is generally considered to have relatively late involvement in recognition memory, its main electrophysiological signature being between 400 and 800 ms after stimulus onset. However, most electrophysiological studies have analyzed the hippocampus as a single responsive area, selecting only a single-site signal exhibiting the strongest effect in terms of amplitude. These classical approaches may not capture all the dynamics of this structure, hindering the contribution of other hippocampal sources that are not located in the vicinity of the selected site. We combined intracerebral electroencephalogram recordings from epileptic patients with independent component analysis during a recognition memory task involving the recognition of old and new images. We identified two sources with different responses emerging from the hippocampus: a fast one (maximal amplitude at ∼250 ms) that could not be directly identified from raw recordings and a latter one, peaking at ∼400 ms. The former component presented different amplitudes between old and new items in 6 out of 10 patients. The latter component had different delays for each condition, with a faster activation (∼290 ms after stimulus onset) for recognized items. We hypothesize that both sources represent two steps of hippocampal recognition memory, the faster reflecting the input from other structures and the latter the hippocampal internal processing. Recognized images evoking early activations would facilitate neural computation in the hippocampus, accelerating memory retrieval of complementary information. Overall, our results suggest that the hippocampal activity is composed of several sources with an early activation related to recognition memory.

Hot metacognition: poorer metacognitive efficiency following acute but not traumatic stress

Aberrations to metacognition—the ability to reflect on and evaluate self-performance—are a feature of poor mental health. Theoretical models of post-traumatic stress disorder propose that following severe stress or trauma, maladaptive metacognitive evaluations and appraisals of the event drive the development of symptoms. Empirical research is required in order to reveal whether disruptions to metacognition cause or contribute to symptom development in line with theoretical accounts, or are simply a consequence of ongoing psychopathology. In two experiments, using hierarchical Bayesian modelling of metacognition measured in a memory recognition task, we assessed whether distortions to metacognition occur at a state-level after an acute stress induction, and/or at a trait-level in a sample of individuals experiencing intrusive memories following traumatic stress. Results from experiment 1, an in-person laboratory-based experiment, demonstrated that heightened psychological responses to the stress induction were associated with poorer metacognitive efficiency, despite there being no overall change in metacognitive efficiency from pre- to post-stress (N = 27). Conversely, in experiment 2, an online experiment using the same metamemory task, we did not find evidence of metacognitive alterations in a transdiagnostic sample of patients with intrusive memory symptomatology following traumatic stress (N = 36, compared to 44 matched controls). Our results indicate a relationship between state-level psychological responses to stress and metacognitive alterations. The lack of evidence for pre- to post-stress differences in metamemory illustrates the importance for future studies to reveal the direction of this relationship, and consequently the duration of stress-associated metacognitive impairments and their impact on mental health.

Representational Dissimilarity of Faces and Places during a Working Memory Task is Associated with Subsequent Recognition Memory during Development.

Nearly 50 years of research has focused on faces as a special visual category, especially during development. Yet it remains unclear how spatial patterns of neural similarity of faces and places relate to how information processing supports subsequent recognition of items from these categories. The current study uses representational similarity analysis and functional imaging data from 9- and 10-year-old youth during an emotional n-back task from the Adolescent Brain and Cognitive Development Study 3.0 data release to relate spatial patterns of neural similarity during working memory to subsequent out-of-scanner performance on a recognition memory task. Specifically, we examine how similarities in representations within face categories (neutral, happy, and fearful faces) and representations between visual categories (faces and places) relate to subsequent recognition memory of these visual categories. Although working memory performance was higher for faces than places, subsequent recognition memory was greater for places than faces. Representational similarity analysis revealed category-specific patterns in face-and place-sensitive brain regions (fusiform gyrus, parahippocampal gyrus) compared with a nonsensitive visual region (pericalcarine cortex). Similarity within face categories and dissimilarity between face and place categories in the parahippocampus was related to better recognition of places from the n-back task. Conversely, in the fusiform, similarity within face categories and their relative dissimilarity from places was associated with better recognition of new faces, but not old faces. These findings highlight how the representational distinctiveness of visual categories influence what information is subsequently prioritized in recognition memory during development.

Do moments of inattention during study cause the error-speed effect for targets in recognition-memory tasks?

The error-speed effect – characterized by a decreased performance in a second recognition task for stimuli that elicited fast error responses in a first recognition task – has so far been predominantly interpreted as evidence for the existence of misleading memory information. However, this neglects a possible alternative explanation, namely that the effect may instead be caused by moments of inattention during study. Here, we introduce a manipulation that allowed us to distinguish between words from the study phase that participants most certainly paid attention to and those they did not. We hypothesized that if moments of inattention cause the error-speed effect, this effect should disappear when considering only targets that verifiably received attention during study. However, our results (N = 89) suggest that this is not the case: The error-speed effect still occurs for targets that participants attended to during study and thus indeed seems to be caused by misleading memory evidence rather than by moments of inattention during study.

Unavoidable social contagion of false memory from robots to humans.

Many of us interact with voice- or text-based conversational agents daily, but these conversational agents may unintentionally retrieve misinformation from human knowledge databases, confabulate responses on their own, or purposefully spread disinformation for political purposes. Does such misinformation or disinformation become part of our memory to further misguide our decisions? If so, can we prevent humans from suffering such social contagion of false memory? Using a social contagion of memory paradigm, here, we precisely controlled a social robot as an example of these emerging conversational agents. In a series of two experiments (ΣN = 120), the social robot occasionally misinformed participants prior to a recognition memory task. We found that the robot was as powerful as humans at influencing others. Despite the supplied misinformation being emotion- and value-neutral and hence not intrinsically contagious and memorable, 77% of the socially misinformed words became the participants' false memory. To mitigate such social contagion of false memory, the robot also forewarned the participants about its reservation toward the misinformation. However, one-time forewarnings failed to reduce false memory contagion. Even relatively frequent, item-specific forewarnings could not prevent warned items from becoming false memory, although such forewarnings helped increase the participants' overall cautiousness. Therefore, we recommend designing conversational agents to, at best, avoid providing uncertain information or, at least, provide frequent forewarnings about potentially false information. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Esketamine enhances memory reconsolidation in the novel object recognition task

Esketamine, the right-handed optical isomer of racemic ketamine, is a rapidly acting antidepressant approved by the FDA for treatment-resistant depression in 2019. However, few studies have investigated esketamine's role in learning and memory, particularly in the context of memory reconsolidation. Herein, we evaluated esketamine's role in memory reconsolidation in 7-week-old male Institute of Cancer Research mice subjected to the novel object recognition (NOR) memory task. The NOR reconsolidation procedure comprised three phases: sampling, reactivation, and testing. Esketamine-enhanced NOR memory performance when injected into mice 0 h after reactivation rather than following a 6 h delay. Conversely, administering esketamine 24 h after sampling without reactivation did not enhance NOR memory performance. Notably, esketamine exhibited no discernible effects on nonspecific responses, such as locomotor activity and exploratory behavior. Furthermore, the α-amino-3‑hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor antagonist NBQX effectively blocked the esketamine-induced enhancement of memory reconsolidation. In conclusion, esketamine treatment markedly improves memory reconsolidation in NOR tasks, and this effect is linked to AMPA receptor activity.

Get the Picture: Learning Referents in a Single-Day Context

Associative learning provides a common substrate for studying learning and memory in language sciences. Studies on recognition memory tasks have found higher proportions of homonyms relative to non-homonyms, indicating a preference or optimum in word learning behavior. This study sought to identify the differences between associative learning for a new word form (pseudowords) and multiple referents (MR) as homonyms and single referents (SR) as non-homonyms. Encoding comprised stimuli for MR, SR, and another condition that comprised pseudowords alone (PW). After the learning phase, two tests were conducted for the participants to judge words from each condition (and an additional condition of untrained word forms), and pictorial referent figures. The results showed that proportions reflecting efficient learning favored SR over MR. The accuracy rates of the verbal working memory task were positively correlated with those of the SR condition in the first recognition task and for the MR condition across recognition tasks. These findings show that associative learning for pseudowords with an SR was more efficient than MR in a single-day learning context. Implications for future research on learning efficiency in vocabulary acquisition and multimedia learning are discussed.

Machine-Learning-Based Prediction of Photobiomodulation Effects on Older Adults With Cognitive Decline Using Functional Near-Infrared Spectroscopy.

Transcranial photobiomodulation (tPBM) has been widely studied for its potential to enhance cognitive functions of the elderly. However, its efficacy varies, with some individuals exhibiting no significant response to the treatment. Considering these inconsistencies, we introduce a machine learning approach aimed at distinguishing between individuals that respond and do not respond to tPBM treatment based on functional near-infrared spectroscopy (fNIRS) acquired before the treatment. We measured nine cognitive scores and recorded fNIRS data from 62 older adults with cognitive decline (43 experimental and 19 control subjects). The experimental group underwent tPBM intervention over a span of 12 weeks. Based on the comparison of the global cognitive score (GCS), merging the nine cognitive scores into a single representation, acquired before and after tPBM treatment, we classified all participants as responders or non-responders to tPBM with a threshold for the GCS change. The fNIRS data were recorded during the resting state, recognition memory task (RMT), Stroop task, and verbal fluency task. A regularized support vector machine was utilized to classify the responders and non-responders to tPBM. The most promising performance of our machine learning model was observed when using the fNIRS data collected during the RMT, which yielded an accuracy of 0.8537, an F1-score of 0.8421, sensitivity of 0.7619, and specificity of 0.95. To the best of our knowledge, this is the first study to demonstrate the feasibility of predicting the tPBM efficacy. Our approach is expected to contribute to more efficient treatment planning by excluding ineffective treatment options.

Judgments of learning reflect the encoding of contexts, not items: evidence from a test of recognition exclusion

ABSTRACT Two sources of evidence seem to be shared by judgments of past recognition and judgments of future performance: item memory or familiarity (i.e., memory for the item independent of the context in which it was experienced) and context memory or recollection (i.e., memory for the context specific to a particular prior encounter). However, there are few studies investigating the link between these two putative memory processes and judgments of learning (JOLs). We tested memory and metamemory using a continuous exclusion procedure – a modified recognition memory task where study events for two classes of items are interleaved with test trials in which the subject must endorse items from one class and reject items from the other. This procedure allowed us to estimate the influences of memory for context and memory for item on JOLs and licenses conclusions about the relative role of item and context information in supporting JOLs. An analysis of forgetting revealed that JOLs reflect both the initial degree of learning and the rate of forgetting, but only of memory for context and not of memory for items. These findings suggest that JOLs are predictive of memory for context-bound episodes, rather than for the semantic content of those episodes.

Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice

The early stages of ageing are a critical time window in which the ability to detect and identify precocious molecular and cognitive markers can make the difference in determining a healthy vs unhealthy course of ageing. Using the 6-different object task (6-DOT), a highly demanding hippocampal-dependent recognition memory task, we classified a population of middle-aged (12-month-old) CD1 male mice in Impaired and Unimpaired based on their short-term memory. This approach led us to identify a different microRNAs expression profile in the hippocampus of Impaired mice compared to Unimpaired ones. Among the dysregulated microRNAs, miR-153-3p was upregulated in the hippocampus of Impaired mice and appeared of high interest for its putative target genes and their possible implication in memory-related synaptic plasticity. We showed that intra-hippocampal injection of the miR-153-3p mimic in adult (3-month-old) mice is sufficient to induce a short-term memory deficit similar to that observed in middle-aged Impaired mice. Overall, these findings unravel a novel role for hippocampal miR-153-3p in modulating short-term memory that could be exploited to prevent early cognitive deficits in ageing.