This study investigates calendar anomalies and their impact on returns and volatility patterns in the cryptocurrency market, focusing on day-of-the-week effects before and during the COVID-19 pandemic. Using advanced statistical models from the GARCH family, we analyze the returns of Binance USD, Bitcoin, Binance Coin, Cardano, Dogecoin, Ethereum, Solana, Tether, USD Coin, and Ripple. Our findings reveal significant shifts in volatility dynamics and day-of-the-week effects on returns, challenging the notion of market efficiency. Notably, Bitcoin and Solana began exhibiting day-of-the-week effects during the pandemic, whereas Cardano and Dogecoin did not. During the pandemic, Binance USD, Ethereum, Tether, USD Coin, and Ripple showed multiple days with significant day-of-the-week effects. Notably, positive returns were generally observed on Sundays, whereas a shift to negative returns on Mondays was evident during the COVID-19 period. These patterns suggest that exploitable anomalies persist despite the market’s continuous operation and increasing maturity. The presence of a long-term memory in volatility highlights the need for robust trading strategies. Our research provides valuable insights for investors, traders, regulators, and policymakers, aiding in the development of effective trading strategies, risk management practices, and regulatory policies in the evolving cryptocurrency market.