Proactive caching of the most popular contents in the cache memory of fog-access points (F-APs) is regarded as a promising solution for the 5G and beyond cellular communication to address latency-related issues caused by the unprecedented demand of multimedia data traffic. However, it is still challenging to correctly predict the user’s content and store it in the cache memory of the F-APs efficiently as the user preference is dynamic. In this article, to solve this issue to some extent, the deep learning-based content caching (DLCC) method is proposed due to recent advances in deep learning. In DLCC, a 2D CNN-based method is exploited to formulate the caching model. The simulation results in terms of deep learning (DL) accuracy, mean square error (MSE), the cache hit ratio, and the overall system delay is displayed to show that the proposed method outperforms the performance of known DL-based caching strategies, as well as transfer learning-based cooperative caching (LECC) strategy, randomized replacement (RR), and the Zipf’s probability distribution.