The vacuum membrane dehumidification and dew point evaporative cooling are potential technologies to handle the latent and sensible heat of the air, respectively. This paper proposes a hybrid system of vacuum membrane dehumidifier and dew point evaporative cooler for air conditioning. A horizontal counter-flow dew point evaporative cooler was designed and developed. The transient and steady-state characteristics of the cooler were judiciously examined. The cooling potential of the cooler itself and the combined system with a membrane dehumidifier were then investigated and compared. Key findings that emerged from this study include: (1) the dew point evaporative cooler alone delivers the product air temperature at 24.8 °C under the hot and humid condition, with the wet bulb effectiveness of 1.05; (2) the hybrid cooling system is able to reduce the ambient humidity to 8.2 g/kg, and the ambient temperature is cooled to below 18.5 °C.