Melanotic Neuroectodermal Tumor Research Articles

Anaesthetic management of a neuroectodermal tumor of infancy: A rare case report

Melanotic neuroectodermal tumor of infancy is a relatively uncommon osteolytic-pigmented neoplasm that primarily affects the jaws of infants. We report a 5-month-old male child who presented with a swelling in the right upper tooth region of upper jaw in which we face difficult mask ventilation as well as difficult intubation. Wide surgical excision was performed under general anesthesia. The uneventful course of anesthesia in the presented case was due to the thorough systemic evaluation and careful anesthetic strategy. Patients of congenital epulis continue to pose challenge to anesthesiologist as a consequence of the potential difficult mask ventilation and intubation. We hereby present a case of congenital epulis repair using diode laser under general anesthesia.

Melanotic neuroectodermal tumor of infancy: Cytology and histopathology of a rare lesion at an uncommon site.

Melanotic neuroectodermal tumour of infancy is a rare, pigmented neoplasm generally arising in infants during the first year of life. The cytological features are rarely described in the literature. This case due to its rarity and unusual site emphasising the cytopathological features and the necessity of histology for differentiating it from other round cell tumours has been presented. Diagn. Cytopathol. 2016. © 2016 Wiley Periodicals, Inc.

Melanotic neuroectodermal tumour of infancy – A rare entity

Melanotic neuroectodermal tumour of infancy (MNTI) is rare, rapidly growing, pigmented neoplasm of neural crest origin. It is generally accepted as a benign tumour despite of its rapid and locally destructive growth. It primarily affects the maxilla of infants during the first year of life. Surgical excision is considered as the treatment of choice. The recurrence rate varies between 10% and 15%, and malignant behaviour has been reported in 6.5% of cases. We report a case of MNTI, associated with an erupted primary tooth in a 5-month-old male child. We discuss the clinical, radiographic and histologic features of this rare tumour, as well as its surgical management and the follow-up.

Melanotic neuroectodermal tumor of infancy

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare pigmented craniofacial tumor of newborns and infants. We report the imaging findings of a 3-month old male patient with a maxillary MNTI. Detailed discussion on imaging features on various magnetic resonance sequences and CT scan are included. Characteristic radiographic appearance is also described. MNTI, of neural crest origin, display a biphasic population of melanin containing cells and neuroblastic cells, within a moderately vascularized fibrous stroma. The child underwent complete surgical excision with no evidence of recurrence at one year follow up. MNTI is an unusual tumor occurring in early childhood with a predilection for the maxilla. Clinical findings, CT scan and MRI may allow a preoperative diagnosis.

Melanotic neuroectodermal tumour of infancy: Unusual histological features in a rare tumour

Melanotic neuroectodermal tumour of infancy: Unusual histological features in a rare tumour

<b>Abordagem odontológica com obturador palatino imediato em um paciente portador de tumor neuroectodérmico melanótico da infância</b>: relato de caso

O objetivo do presente artigo é relatar a abordagem odontológica com obturador palatino imediato diferenciado em um caso clínico de tumor neuroectodérmico melanótico da infância, ocorrido no Instituto Nacional de Câncer José Alencar Gomes da Silva, realizando uma revisão da literatura e abordando o atendimento multidisciplinar como garantia do cuidado
 integral ao paciente. Lactente, 4 meses, sexo masculino, tumoração
 em maxila esquerda, foi encaminhado à seção de Odontologia para confecção de obturador palatino com projeção maxilar. O paciente que é submetido
 a um tratamento mutilador na tentativa de cura de alguma neoplasia de cabeça e pescoço necessita de conforto, bem-estar e um cuidado integral da equipe
 multidisciplinar, sendo o cirurgião-dentista parte dessa equipe.

Benign but Aggressive Tumors of Infancy Report of Two Cases

Melanotic neuroectodermal tumour of infancy and Aggressive desmoid fibromatosis are histologically benign tumors but with aggressive behavior, it’s occurring during the little infancy and are caracterised by Fast-growing, osteolysis and recurrence. The treatment is essentially surgical. Melanotic neuroectodermal tumour of infancy is a rare tumour which affects young children arising from neural crest with a black coloring. It grows rapidly and first touches the maxilla. We related the case of a three-month age male who presents a tumor in the right maxilla. The case have CT scan and histology feature. Aggressive desmoid fibromatosis is a benign tumor with locally infiltrative behavior and tendency to recur. We report a rare case involving the mandible arch of three years old girl with histopathological, immunohistochemical and imaging features. She underwent a large surgically resection of the arch of the mandible, there has been no recurrence three years after.

Obturator Prostheses for Melanotic Neuroectodermal Tumor of Infancy in the Maxilla

Melanotic neuroectodermal tumor of infancy frequently affects the maxilla. A communication between the oral and nasal cavities can be created by surgery. The authors rehabilitated a young patient with obturator prostheses to correct feeding. The association of the obturators with orthodontic devices provided proper maxillary growth and eruption of teeth. The outcomes were very satisfactory after a 3-year follow-up, and dental implants are planned.

Melanotic Neuroectodermal Tumor of Infancy Presenting with Fast Growing Scrotal Swelling: A Case Report and Literature Review

Testicular melanotic neuroectodermal tumor of infancy (MNTI) is extremely rare, with 2 cases reported in the literature. Its rarity, rapid and infiltrative growth pattern pose a diagnostic challenge. A previously healthy 3-month old male, presented with a history of worsening left hemiscrotal swelling for one week. An outside ultrasound was suggestive of testicular torsion. Left orchiectomy demonstrated a mass occupying almost entire testicle with a variegated cut surface, with areas of pigmentation, necrosis and hemorrhage. Histological examination confirmed MNTI of the testis and epididymis. MNTI should be included in differential diagnosis in infants presenting with fast growing scrotal swelling.

Melanotic Neuroectodermal Tumor of Infancy: A Case Report

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign, fast-growing, melanin-containing tumor originating from the neural crest. MNTI can present locally aggressive behavior including bone destruction. A 2-month-old female presented a bluish swelling, with well-defined limits, in the premaxilla. Computed tomography revealed a homogeneous and hypodense image associated with the upper left central primary incisor. The diagnostic hypothesis was dentigerous cyst. An incisional biopsy was performed, and microscopic examination revealed a benign neoplasm exhibiting proliferation of a dual population of cells arranged in solid nests or cords. The first cell type consisted of small rounded cells with scarce cytoplasm, and the second consisted of epithelioid cells containing brown cytoplasmic granules consistent with melanin. Based on these findings, the definitive diagnosis was MNTI. Surgical excision was performed, and there was no tumor recurrence during 1 year of follow-up.

Melanotic neuroectodermal tumor of infancy: A case report and review of the surgical treatment.

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing, benign tumor originating from the neural crest. The tumor most often occurs during the first year of life. The predilection site of MNTI is the anterior maxilla, whereas lesions of the mandible are uncommon and account for only 6% of all cases. At present, the most common treatment for MNTI is surgical resection, however, tumor recurrence arises in 10–60% of cases. The optimal extent of surgical resection is a matter of debate; rapid growth and the possibilities of malignant transformation and metastasis indicate aggressive surgical resection. However, extensive resection may interfere with post-operative growth and development. The procedure should therefore preserve as much of the surrounding tissue as possible. The present case study examines a rare case of right-sided mandibular MNTI in a two-month-old female. The association between the tumor and the surrounding sclerotin, affected dental germ and the condition of the inferior alveolar nerve, were observed during the operative and post-operative periods. In addition, previous cases of MNTI were reviewed to evaluate the optimal scope of surgical resection.

Ectopic eye in the maxilla: a report of melanotic neuroectodermal tumor of infancy with an unusual histologic finding and subsequent reconstruction

Ectopic eye in the maxilla: a report of melanotic neuroectodermal tumor of infancy with an unusual histologic finding and subsequent reconstruction

Melanotic Neuroectodermal Tumor of Infancy

Two baby’s, one was 6 months old and another was 2 months old presented with a rapidly progressing melanotic neuroectodermal tumor of infancy (MNTI) in the maxilla. The tumor extended from the midline to the retromolar area of the left maxilla. It was confirmed as a melanotic neuroectodermal tumor through, radiology, cytology and histopathological examinations. The encapsulated tumor was excised .No recurrence was seen in the initial follow up nearly one year. DOI: http://dx.doi.org/10.3329/pulse.v5i1.20194 Pulse Vol.5 January 2011 p.61-65

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades.

The spectrum of testicular tumors and tumor-like lesions that affect young patients (defined for purposes of this article as less than 20 years old) differs significantly from that in an older age group. Although germ cell tumors remain the single largest category, they are a smaller proportion than in adults. Furthermore the pathogenesis and behavior of comparably named germ cell tumors differ depending on whether or not they have developed in prepubertal or postpubertal patients. This is most apparent for the teratomas, which are almost uniformly benign in children but, with some notable exceptions, malignant in the older patients. But even the most common malignant tumor of the testis in children, the yolk sac tumor, despite its identical morphology, lacks the association with other germ cell tumor types, including intratubular germ cell neoplasia, and more aggressive behavior that typify the adult tumors. Among the sex cord-stromal tumors, the juvenile granulosa cell tumor predominates in children, mostly occurs in those under 1-year old, and, for all intents and purposes, is not seen in the postpubertal period. It has a distinctive morphology and, to date, a uniformly benign outcome. There are additional tumors in the sex cord-stromal group that are mostly seen in young patients, including the large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia. The former is sometimes associated with the Carney syndrome and, to date, all of the latter with the Peutz-Jeghers syndrome. The subtypes of lymphomas and leukemias that involve the testis in children are rare in older patients, and similar remarks pertain to the metastatic tumors, where neuroblastoma (especially) and Wilms׳ tumor are most common but may be mimicked by primary tumors originating in the paratestis. The pseudoneoplastic lesion, the testicular "tumor" of the adrenogenital syndrome, is usually found in young patients and bears a strong resemblance to the Leydig cell tumor, although there are features that allow its distinction, which is important given its frequently bilateral nature and amenability to medical management through glucocorticoid administration. One of the preferential sites for embryonal rhabdomyosarcoma is the paratestis of young patients, where the spindle cell variant predominates. The melanotic neuroectodermal tumor (retinal anlage tumor) usually occurs in the first year of life, typically involves the epididymis, and uncommonly metastasizes. Occasional cases of the desmoplastic small round cell tumor present in the paratestis of teenagers, and some distinctive tumor-like lesions of the paratestis may also be seen, including meconium periorchitis and splenic-gonadal fusion (occupying both testis and paratestis). These tumors and tumor-like lesions and many others are discussed in this review with the hope it will provide the diagnostic pathologist aid in recognizing the lesions and providing some insight into their clinical significance.

Melanotic Neuroectodermal Tumor Of Infancy: Case Report With 1-Year Follow-Up

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, fast-growing tumor with a high recurrence rate. Commonly it develops in the anterior maxilla of children younger than age 1 year. Tumor origin is the neural crest. Girl, 2 months, had an increasingly large area of swelling on the left cheek. After tomography and biopsy, the diagnosis of MNTI was established. Histological examination indicated a remarkable combination of neural, melanocytic, and epithelial cell differentiation. One year after tumor excision, the child has had no recurrence. Since its first description, about 260 cases of this tumor have been reported. Early diagnosis minimized difficulties and risks during treatment and leads to an optimal outcome. Despite complete surgical excision, careful follow-up is recommended. Maxillary functional orthopedic care and reconstruction may be necessary.

Melanotic neuroectodermal tumour‐ difficult airway management in an infant

SummaryNeuroectodermal tumours of the maxilla present challenges for airway management due to the age of the patient and tumour involvement in the oral cavity. A careful preoperative evaluation and awareness of a potentially difficult airway are necessary. Good communication between the anaesthetic and surgical teams are vital. The laryngeal mask airway can be a useful device as it provides good airway control in paediatric patients with difficult airways and can also be used to aid fibreoptic tracheal intubation.

Oral melanotic neuroectodermal tumor of infancy

Melanotic neuroectodermal tumor of infancy (MNTI) is an extremely rare, benign neoplasm of neural crest origin composed of relatively primitive pigment-producing cells. It usually affects new born or infants of <1 year of age, generally involving the face or cranium. This case report describes a 4-month-old child with MNTI involving the anterior region of maxilla. A partial maxillectomy was performed on the left side of maxilla and the patient is now under follow-up.

Melanotic Neuroectodermal Tumor of Infancy Disseminated by a Ventriculoperitoneal Shunt and Diagnosed from the Inguinal Sac

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare congenital neoplasm that originates from the neural crest cells, which give rise to the melanocytes of the skin and leptomeninges. We report a case of MNTI with neurocutaneous melanosis of a 28-month-old girl. She was born with hydrocephalus and several large congenital giant nevi. There were no findings except for hydrocephalus, after a ventriculoperitoneal (VP) shunt operation performed when she was 6 months old. She was operated on for a growing inguinal mass at 8 months. The specimen from the inguinal sac was positive for HMB45, vimentin, chromogranin, and neuron-specific enolase. Brain magnetic resonance imaging showed an extensive enhancing extra-axial mass with high signal intensity, along the cerebral spinal fluid space. We report a rare case of MNTI, diagnosed from an inguinal hernia sac, with a disseminated clinical manifestation.

Melanotic neuroectodermal tumor of infancy: Presentation of a case

The melanotic neuroectodermal tumor of infancy (MNTI) is a fairly rare, benign, pigmented lesion with a rapid expansile growth and a high recurrence rate that commonly occurs in the anterior maxilla of infants younger than 1 year and mainly in the first 6 months of life. Microscopically, large polygonal epithelioid cells resembling melanocytes, with variable deposits of melanin, and smaller neuroblast-like round cells characterize MNTI. Malignant transformation may occur. The tumor was first described by Krompecher in 1918 as a congenital melanocarcinoma. In 1992, the designation MNTI was accepted by and used in the World Health Organization classification of odontogenic tumors. One such case was diagnosed in the department of oral pathology and microbiology and is presented.

Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report

Melanotic neuroectodermal tumor of infancy (MNTI) is a rare condition that occurs normally in the anterior maxilla of infants aged <1 year. The use of clinical and imaging tools for MNTI is extremely important to prevent problems with function as well as the aesthetic features in a breastfeeding child. Brazil is a multiethnic country with a poor epidemiological policy and little data to track the incidence of certain diseases, including MNTI. It is important to study this pathology with ethnicity as a factor to improve the current epidemiological programs and establish better post-treatment management. This paper describes a case of a 2-month-old male of African-indigenous descent and Brazilian Amazon residency, who presented to our unit in 2009 with a history of an expanding mass involving the anterior maxilla. Clinical and computerized tomography scans were used to diagnose the mass as MNTI, which was removed by total excision. A biopsy later confirmed the MNTI diagnosis.