Introduction: Meier-Gorlin syndrome (MGS) has three characteristics: short stature, a small or absent patella, and microtia. Objective: This case report aimed to evaluate orthodontic surgical treatment in a patient with MGS during a 7-year follow-up. Methods: A multidisciplinary approach was performed involving orthodontics and maxillofacial surgery. In the initial phase, orthodontic procedures were performed using rapid expansion of the mid-palatal suture. Orthodontic appliances (Roth prescription) were used and orthodontic decompensation was performed, followed by orthodontic surgery to make aesthetic and functional changes. Results: Surgical orthodontic treatment reduced proclination and protrusion and improved overbite. An adequate correlation of the upper and lower arches was achieved. Aesthetic and functional changes were observed, as well as the opening of the airways. Conclusion: This case report highlights the importance of orthodontic surgical correction to achieve symmetry and functionality, given the facial and physical characteristics present in this syndrome.