Medication Compliance In Patients Research Articles

30. Knowledge and Medication Compliance In patients with Hypertension at Posbindu in Seroja Health Care Working Area

Background: The global prevalence of hypertension is 22% of the total world population and Indonesia found 34.1% population with hypertension at the age of > 18 years. Based on the proportion of history of taking medication, 32.3% did not take medication regularly, and 13.3% did not take antihypertensive medication. Compliance with hypertension treatment is important because hypertension is an incurable disease and treatment can affect the patient's recovery and complications. Objective: This study aims to determine the relationship between Patient Knowledge and medication compliance for hypertension Patients at Posbindu in Seroja Health Care Working Area. Bekasi. Method: A total of 90 residents were enrolled from Posbindu in the Seroja Health Care Working Area stratified with purposive sampling for a month. A face-to-face questionnaire survey was conducted by trained investigators. Result: This study shows that the patient percentages with good knowledge are 67.8%, 12,2% with sufficient knowledge, and 20% with poor knowledge of hypertension. 62.2% of respondents were not obedient to having hypertension medication. The Chi-Square test shows the value of probability p value 0.001 (p 0.001, r = 0.374). Conclusion: There is a significant relationship between the level of knowledge and medication compliance in hypertensive patients at Posbindu in the Seroja Health Care Working Area.

Research development on medication compliance of patients with bipolar disorder in China

Research development on medication compliance of patients with bipolar disorder in China

Analysis of patient medication compliance and quality of life of physician-pharmacist collaborative clinics for T2DM management in primary healthcare in China: A mixed-methods study.

Background: Physician-pharmacist collaboration is a well-established care mode for the management of type 2 diabetes mellitus (T2DM) in developed countries, but no study has been conducted in primary healthcare in China. This study aims to evaluate the effects of physician-pharmacist collaborative clinics to manage T2DM in primary healthcare in China, and to better understand the factors influencing the implementation of physician-pharmacist collaborative clinics. Methods: Two hundred and sixty-seven patients involved in a 12-month randomized controlled trial were assigned to physician-pharmacist collaborative clinics and usual clinics, completing surveys regarding medication compliance, quality of life (QoL) and care-seeking behavior at the baseline, 3rd, 6th, 9th and 12th month respectively, and diabetes knowledge at baseline and 12th month. A sample of twenty-two Patients, nine physicians and twelve pharmacists participated in semi-structured face-to-face interviews. The quantitative and qualitative data was integrated by triangulation. Results: Patients in physician-pharmacist collaborative clinics had significant improvements in medication compliance (p = 0.009), QoL (p = 0.036) and emergency visits (p = 0.003) over the 12-month. Pairwise comparison showed the medication compliance score in the intervention group had been significantly improved at 3rd month (p = 0.001), which is more rapidly than that in the control group at 9th month (p = 0.030). Factors influencing the implementation of physician-pharmacist collaborative clinics were driven by five themes: pharmaceutical service, team-base care, psychological support, acceptability of care and barriers to implementation. Conclusion: Integration of quantitative and qualitative findings showed the effectiveness of physician-pharmacist collaborative clinics in patient medication compliance and QoL in primary healthcare. The qualitative study uncovered barriers in insufficient clinical experience and understaffing of pharmacist. Therefore, the professional training of the primary pharmacist team should be improved in the future. Clinical Trial Registration: clinicaltrials.gov, identifier ChiCTR2000031839.

Results of a Pilot Study for a Pharmacy Discharge Review in Neurosurgical Patients: A Quality-Safety Initiative.

Objective A multidisciplinary collaboration between the neurosurgical team and the pharmacy was established to conduct a pilot study in which discharged neurosurgical patients from a community hospital would receive medication reconciliation services and counseling by a pharmacy specialist to determine the impact on patient safety, readmission rates, and medication compliance. Methods Pharmacists reviewed discharge medication reconciliations of neurosurgical patients to address any discrepancies with the nurse practitioners or physicians prior to discharge and provided discharge medication counseling to the patient/families at the bedside. The service was provided on weekdays during the eight-hour pharmacist shiftin addition to other daily responsibilities. Data were analyzed by type and the total number of pharmacy interventions encountered during the discharge medication reconciliation process, time to complete services, and readmission rates. Lastly, the discharged neurosurgical patients that were not seen by pharmacists during the one-month pilot study were reviewed retrospectively to determine potential interventions. Results A total of 48 neurosurgical patients were discharged during the one-month pilot study; 27 patients received discharge medication reconciliation services and counseling from the pharmacy specialists. Sixty-three pharmacy interventions were accepted with prevention of medication errors/adverse drug reactions (21%, n=21) and addition of missing medication (21%, n=21) being the most common intervention types. The mean time to complete the services was 27 minutes and there was one non-medication-related readmission of the 27 patients seen. Twenty-one neurosurgical patients who were discharged without receiving services were reviewed retrospectively. It was determined that there was a potential for another 64 pharmacy interventions in which clarification of indication (33%, n=21) was the most common intervention type, followed by prevention of medication errors/adverse drug reactions (25%, n=16) and addition of missing medication (22%, n=14). There was a total of one medication-related readmission of the 21 patients not seen by the pharmacist during the pilot study. Conclusion The collaboration of pharmacists in the discharge process benefits neurosurgical patients by reducing the number of discrepancies when transitioning home and provides an additional layer of safety to reduce medication errors and/or prevent adverse events.

Evaluation of Photostability of Medicines and Development of the Photostabilization of the Photosensitive Medicines

Photo-exposure has a crucial effect on both the quality and quantity of photosensitive pharmaceuticals due to the decrease of their contents or the expression of adverse effects derived from generated photoproducts. The photostability test guidelines (ICH-Q1B, Photostability testing of new drug substances and products) have been established for the photostability evaluation in the new drug application, and obtained results from these tests are required for the elucidation of the final packaging and the dosage form. However, there is no information in the interview form about the photostability of medicines that are taken out from a press through package (PTP) sheet and their dosage forms are changed for the purpose of the improvement of medication compliance of patients. It is an important issue to clarify the photostability of medicines that are crushed or suspended and determine the potential photoproducts for safe use. Herein, in this review, results of the evaluation of the photodegradability of photosensitive active pharmaceutical ingredients (APIs) and their formulations, the determination of several photoproducts generated by ultraviolet-light (UV) irradiation and the development of photostabilization strategy for them based on the addition of several photostabilizers are summarized.

Clinical pharmacists’ intervention on pain management in cancer patients (PharmaCAP trial): study protocol for a randomized controlled trial

IntroductionEvidence-based services to support cancer patients with pain via clinical pharmacy services are currently lacking. Therefore, there is a need to undertake a randomized controlled trial (RCT) to explore the effectiveness of clinical pharmacists (CPs)’ input into the multidisciplinary team (MDT) in providing better therapeutic outcomes for cancer pain management.ObjectivesThe main aim of this pilot RCT is to determine the feasibility and preliminary efficacy of integrating CPs into the MDT for cancer pain management on the clinical outcomes of cancer patients experiencing pain.MethodsThis study protocol outlines two-armed multicenter pilot RCT. Cancer patients suffering from pain will be randomly allocated to receive either clinical pharmacy services, i.e., PharmaCAP trial intervention from the CP, or the usual standard care (i.e., control group). Patients will be recruited consecutively from two hospitals in Kathmandu valley, Nepal. The outcomes will be assessed at baseline (pre-intervention) and 4 weeks post-intervention. The primary feasibility outcomes will include eligibility rate, recruitment rate, willingness to participate, acceptability of screening procedures and random allocation, possible contamination between the groups, intervention fidelity and compliance, treatment satisfaction, and patient understanding of the provided interventions. Subsequently, the primary clinical outcome, i.e., pain intensity of cancer patients, will be assessed. The secondary clinical outcomes will include health-related quality of life (HRQoL), anxiety, depression, adverse drug reactions, and patient medication compliance following the integration of CP into the healthcare team.DiscussionThe feasibility and potential for integrating CP involvement in MDT to improve clinical outcomes of cancer patients with pain will be evaluated through the PharmaCAP trial.Trial registration: ClinicalTrials.gov NCT05021393. Registered on 25th August 2022.

Retracted: Analysis of Influencing Factors of Medication Compliance in Patients with Recurrent Vertebral Fractures after Percutaneous Kyphoplasty and the Role of Family-Centered Education Intervention.

[This retracts the article DOI: 10.1155/2021/3974674.].

Evaluation of pharmacokinetic interactions between lobeglitazone, empagliflozin, and metformin in healthy subjects.

ClinicalTrials.gov Identifier: NCT04334213.

Retracted: Changes in the Quality of Life, Psychological Status, Medication Compliance, and Prognosis of Patients with Acute Myocardial Infarction after PCI by Applying PDCA Cycle Management Model.

[This retracts the article DOI: 10.1155/2021/7318653.].

Acupoint Thread Embedding Combined With Wenshen Bugu Decoction for the Treatment of Aromatase Inhibitor-Associated Musculoskeletal Symptom Among Postmenopausal Breast Cancer Patients: Study Protocol of a Randomized Controlled Trial.

Aromatase inhibitors (AIs) are recommended as the preferred therapy for postmenopausal women with hormone receptor-positive (HR+) breast cancer. As a result, aromatase inhibitor-associated musculoskeletal symptom (AIMSS) have become a major problem leading to therapy discontinuation and decreased quality of life in patients receiving adjuvant AIs treatment. Multiple therapies have been attempted, but have yielded limited clinical results. This study will be performed to determine whether acupoint thread embedding (ATE) combined with Wenshen Bugu Decoction can effectively treat AIMSS, so as to improve the AIs medication compliance of postmenopausal breast cancer patients. This study will utilize a randomized, 2 parallel groups controlled trial design. A total of 128 eligible postmenopausal breast cancer women with AIMSS will be randomized to receive a 12-week treatment with Wenshen Bugu Decoction alone (control group) or in combination with ATE (treatment group) in a 1:1 ratio. The primary outcome will be the 12 week Brief Pain Inventory Worst Pain (BPI-WP) score. The secondary outcome measures will include response rate, Brief Pain Inventory-Short Form (BFI-SF), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Functional Assessment of Cancer Therapy-Endocrine Symptom (FACT-ES), Functional Assessment of Cancer Therapy-Breast (FACT-B), bone marrow density (BMD), blood markers of bone metabolite, Morisky medication adherence scale-8 (MMAS-8), credibility and expectancy, and survival outcomes. This trial may provide clinical evidence that ATE combined with Wenshen Bugu Decoction can be beneficial for treating AIMSS among postmenopausal breast cancer survivors. Our findings will be helpful to enhance the quality of life and reduce the occurrence of AIs withdrawal.

Treatment strategies and pharmacist-led medication management for Helicobacter pylori infection.

Half of the world's population is Helicobacter pylori carrier. Updated guidelines and consensus have been issued across regions with the main aim of reducing social transmission and increasing H. pylori eradication rate. Although alternative therapies including traditional Chinese medicineand probiotics have also been used to improve H. pylori eradication rate in clinical practice, current mainstream treatment is still dependent on triple and quadruple therapies that includes antibacterial agents (e.g., amoxicillin and furazolidone) and proton pump inhibitor.Researches also assessed the eradication rate of optimized high-dose dual therapy in treating H. pylori infection. With the increase of antibiotic resistance rate, the treatment strategies for H. pylori infection are constantly adjusted and improved. Besides, low medication compliance is another key influencing factor for H. pylori treatment failure. Emerging studies indicate that pharmacists' intervention and new pharmaceutical care methods can enhance patient medication compliance, reduce adverse drug reactions, and improve H. pylori eradication rate. The purpose of this review is to summarize the advances in treating H. pylori infection and highlight the necessity of developing novel strategies to cope with the increasing challenges and to achieve personalized medication. Also, this review attaches great importance to pharmacists in optimizing H. pylori treatment outcomes as a routine part of therapy.

The Relationship Between Medication Compliance And Relapse In Schizophrenia Patients

Many factors can cause relapse in schizophrenia patients. Non-compliance to taking medication is one of the factors that cause relapse in schizophrenia patients. In patients with schizophrenia, noncompliance to medication is a common occurrence driven by many factors and is considered a significant contributor to relapse. This research is an observational study using a cross-sectional study design. The population in this study were the families of Schizophrenia patients who were treated in the Sawo Room, Madani Hospital, Central Sulawesi Province when the study was conducted. The sample size is 48 patients. The purposive sampling technique was used for the sampling method. The Chi-Square was used for the hypothesis test with a significance level of p < 0.05. Based on the results of the study, it was found that there was a significant relationship between medication compliance and relapse in schizophrenia patients at Madani Hospital, Central Sulawesi Province with P Value = 0.000 (< 0.05). It can be concluded that there is a relationship between medication compliance and relapse in schizophrenia patients. The hospital is expected to improve the ability of nurses to cooperate with all parties, especially families in caring for schizophrenic patients so that the recurrence of schizophrenic patients can be prevented.

An Orthopaedic Surgeon Led Osteoporosis (OSLO) Model of Care reduces early recurrent fracture rates and improves treatment compliance in patients treated for osteoporotic fractures.

This study aims to evaluate the efficacy of an Orthopaedic Surgeon Led Osteoporosis Model of Care (OSLO-MoC) as compared to a Case Manager Led Osteoporosis Model of Care (CMLO-MoC) in reducing early osteoporotic re-fracture rates and treatment compliance in patients. This was a single centre, retrospective, comparative cohort study of all patients screened and treated for secondary osteoporotic fracture prevention from the 2008 to 2018 at an orthopaedic surgical unit. From the 2008 to 2013, patients were recruited under the CMLO-MoC and from 2014 to 2018, under the OSLO-MOC. Logistics regression analysis was used to identify significant predictors such as OSLO-MOC implementation, gender, ethnicity, marital status and education level for patient recruitment, treatment compliance and secondary fracture rates at 12-month follow-up. Over a 10-year period, 7388 patients were screened of which 2855 patients were eligible for analysis. A total of 1234 patients were recruited under CMLO-MoC and 1621 patients under OSLO-MOC. Implementation of the OSLO-MOC was associated with greater patient recruitment, OR 1.26 (95%CI 1.06-1.49, P = 0.007). Of the 2855 patients recruited, OSLO-MOC implementation, OR 2.61 (95%CI 2.03-3.36, P < 0.001), and a higher level of education, OR 1.428 (95%CI 1.02-1.43, P = 0.037), were associated with improved compliance to medication at 12months. OSLO-MOC implementation was the only factor associated with reduced risk of secondary fractures at 12months, OR 0.14 (95%CI 0.03-0.66, P = 0.013). The OSLO-MOC has shown to be effective in reducing the rate of re-fracture and osteoporotic medication initiation and compliance of patients. IV.

Construction and application of tuberculosis medical and nursing integration cooperation model.

To explore the clinical effect of the tuberculosis (TB) doctor-nurse integration management model METHODS: This study is a retrospective historical cohort study. The clinical data of 180 patients with TB in our hospital from 2019 to 2020 were analyzed retrospectively. In a control group, 90 cases were treated with the traditional medical care model. An observation group of 90 cases received clinical diagnoses, treatments, and nursing under a doctor-nurse integration management model. Comparative analyses between the two groups were conducted on various aspects, including the awareness level of TB prevention and control, medication compliance and patient satisfaction. Comparisons between the two groups were evaluated using independent-sample t-tests or Chi-squared tests RESULTS: Compared with the control group, the knowledge awareness levels of TB prevention and medication compliance in the observation group were significantly higher (p <.05). The appointment waiting times and hospitalization times in the observation group were significantly lower than in the control group (p<.05). The total average satisfaction score of the patients in the observation group was significantly higher than in the control group (p<.05). Compared with the control group, the patients in the observation group were significantly more satisfied with their nursing methods, operating techniques, psychological techniques, service attitudes, and ward management (p<.05). In addition, in the observation group, medical-nursing relationships and doctor-patient communication were better than in the control group; additionally, the satisfaction of doctors with nursing work was also higher than in the control group, which was a statistically significant difference (p<.05) CONCLUSION: The implementation of an integrated medical-nursing cooperation model for TB will help increase the awareness of health knowledge in patients with TB, improve patient medication compliance and enhance patient satisfaction.

311.9: Nurse-Involved Intervention Strategies for Medication Compliance in Kidney Transplant Recipients: A Systematic Review

Objective: To evaluate the intervention strategies for medication compliance of kidney transplantation recipients with nurses’ participation systematically, and to provide evidence-based evidence for nursing staff to formulate intervention strategies. Methods: BMJ Best Practice, UpToDate, Joanna Briggs Institute, The Cochrane Library, Guidelines International Network, Registered Nurses’Association of Ontario, Scottish Intercollegiate Guidelines Network, National Guideline Clearinghouse, PubMed, EmBase, Web of Science, CNKI, WangFang Data. Sinomed were searched to collect evidence of nurse-involved intervention strategies for medication compliance in kidney transplant recipients.The time limit for the retrieval is from the inception of databases until August 7, 2021. 2 researchers screened studies, extracted the data and evaluated the quality of included studies independently. Results: A total of 22 randomized controlled trials were included in this study.At present, the intervention strategies for medication compliance of kidney transplant recipients with nurses’ participation involving clinical pharmaceutical care, behavioral intervention, education, electronic monitoring and reminder, telemedically supported case management, cognitive behavioral therapy, mobile drug manager application, etc. Conclusion: Nursing staff should pay attention to the poor medication compliance of kidney transplant recipients, more participate in the formulation and implementation of intervention programs actively, and use existing evidence-based evidence to help kidney transplant recipients improve medication compliance. Caregivers could consider cognitive behavioral therapy, behavioral intervention and education intervention strategies, but there is insufficient evidence of existing nurse-involved intervention strategies for medication compliance of kidney transplantation patients, and the selection of the best intervention strategy is difficult and complex. High-quality, large-sample studies are still needed in the future. National Natural Science Foundation of China The Project Approval Number: 71904209.

Clinical Analysis on the Effects of Tandospirone Citrate Assisted by Drawing Therapy on Medication Compliance and Sleep Quality in Patients with Anxiety Disorders.

Objective To explore the clinical effects of tandospirone citrate assisted by drawing therapy (DT) on medication compliance and sleep quality in patients with anxiety disorders. Methods A total of 128 patients with anxiety disorders treated in the hospital were enrolled between January 2020 and January 2022. According to the random number table method, they were divided into the observation group (n = 64) and the control group (n = 64). The control group was treated with tandospirone citrate, while the observation group was additionally treated with DT. The clinical curative effect and medication compliance after treatment, scores of Hamilton Anxiety Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI), and the World Health Organization's Quality of Life Questionnaire-Brief Version (WHOQOL-BREF) before and after treatment were compared between the two groups. The occurrence of adverse reactions during treatment was recorded. Results After treatment, the total response rate in the observation group was higher than that in the control group (96.88% vs 86.94%) (P < 0.05). After treatment, scores of HAMA and PSQI in both groups were decreased, which were lower in the observation group than in the control group (P < 0.05). After treatment, medication compliance in the observation group was higher than that in the control group (P < 0.05). After treatment, scores of environmental factors, social relations, physiological function, and psychological status in both groups were increased, which were higher in the observation group than in the control group (P < 0.05). During treatment, there was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion DT-assisted tandospirone citrate can effectively improve the clinical symptoms of patients with anxiety disorders, improve medication compliance, sleep quality, and quality of life, and have a certain degree of safety.

Underlying Role of Rumination-Mediated Attachment Style Plays in PTSD after TIA and Stroke.

Objective: Attachment and rumination were examined as the intermediary variables on post-traumatic stress disorder and medication compliance in stroke or TIA patients. Methods: A total of 300 participants with stroke or TIA from the Second Hospital of Hebei Province were selected. Patients accomplished NIHSS, ABCD2, ECR, RSQ, and RRS on admission. After 3 months, the PCL-C and MMAS were collected. Results: In the stroke or TIA patients, the incident of PTSD was 7.7%; PTSD scores were significantly associated with attachment anxiety (r = 0.225, p < 0.01), symptom rumination (r = 0.197, p < 0.01), and obsessive thinking (r = 0.187, p < 0.01). After the Sobel test analysis and verification by the Baron and Kenny’s stepwise approach we found that ruminant mediated the relationship between attachment anxiety and PTSD; obsessive thinking mediated the relationship between attachment anxiety and PTSD. Conclusions: The relationship between attachment anxiety and PTSD was positively predicted by rumination and obsessive thinking. Adult attachment style, rumination, and PTSD scores may not predict medication compliance.

Vitamin AD Drops are More Effective than Intramuscular Injection of Thymosin in Reducing the Rate of Growth Retardation in Children.

Objective To explore the effect of vitamin AD drops on growth retardation in children. Methods From February 2020 to February 2021, 100 children with constipation and recurrent respiratory infections treated in our hospital were assigned to a vitamin AD drops group and intramuscular thymosin group, with 50 cases in each group. Outcome measures included mean height, body mass index (BMI), frequency of respiratory infections, increase in height and BMI, growth retardation, clinical effectiveness, immune function, medication compliance, and adverse responses. Results The vitamin AD drops group showed higher mean height (t = 5.958, P < 0.05), greater body mass (t = 3.997, P < 0.05), and less frequency of respiratory infections than the intramuscular thymosin group (t = 26.564, P < 0.05). The vitamin AD drops group resulted in a lower ratio of height increase of >1 cm and a higher ratio of >2 cm as compared with the intramuscular thymosin group (χ2 = 8.167, P < 0.05). The vitamin AD drops group showed a lower ratio of weight gain of 0 and > 1 kg and a higher ratio of >2 kg versus the intramuscular thymosin group (χ2 = 4.058, P < 0.05). Vitamin AD drops resulted in a significantly lower growth retardation rate than intramuscular thymosin administration (χ2 = 5.530, P < 0.05). The vitamin AD drops group yielded markedly higher treatment efficiency in contrast to the intramuscular thymosin group (Z = 2.111, P < 0.05). The levels of CD3+CD4+, CD3+CD8+, CD4/CD8, IgA, IgG, and IgM in the two groups of patients after medication were higher than those before medication (P < 0.05), with higher levels in the vitamin AD drops group compared with the intramuscular thymosin group (P < 0.05). The vitamin AD drops group showed remarkably higher medication compliance in patients versus the intramuscular thymosin group (Z = 2.239, P < 0.05). The vitamin AD drops group experienced a significantly lower incidence of adverse reactions (χ2 = 4.396, P < 0.05). Conclusion Vitamin AD drops are more effective than the intramuscular injection of thymosin in reducing the incidence of growth retardation in children.

A Study of the Nursing Intervention Based on Self-Efficacy Theory for Patients After Mechanical Heart Valve Replacement: A Randomized Controlled Trial.

AimTo explore the practicability and efficiency of self-efficacy intervention on the nursing for patients after mechanical heart valve replacement (MHVR), so as to provide a theoretical and data foundation for the implementation of self-efficacy intervention in clinical practice.MethodsThis study adopted a randomized controlled trial (RCT). A total of 140 patients undergoing MHVR were randomly divided into the experimental group (normal nursing + self-efficacy intervention) or the control group (normal nursing only) based on a random number table. The primary goal was to evaluate the effect of self-efficacy theory on the self-efficacy of postoperative MHVR patients by General Self-Efficacy Scale (GSES). The secondary goal was to assess the improvement of mental health of postoperative patients as well as their pain through Symptom Checklist 90 (SCL-90) and the visual analogue scale (VAS). The incidence of infection during hospitalization was analyzed, as well as the medication compliance of patients during 3-month follow-up after discharge.ResultsFinally, 136 patients completed the whole trial. The GSES score of the experimental group was notably superior over the control group (p < 0.001), and the SCL-90 scores were lower over the control group. The VAS score of the experimental group was remarkably lower than that of the control group (p < 0.001). The incidence of infection in the experimental group was lower than that in the control group (p = 0.026). The medication compliance of the experimental group was superior to that of the control group (p = 0.030).ConclusionSelf-efficacy intervention for patients after MHVR could mobilize their self-efficacy, enhance their postoperative medication compliance, and improve their postoperative recovery. This study provides evidence-based medicine (EBM) evidence for the application of self-efficacy theory to postoperative nursing for patients receiving MHVR.

Validity and Reliability of the Thai Version of the 19-Item Compliance-Questionnaire-Rheumatology.

PurposeTo evaluate the psychometric properties and feasibility of the Thai version of Compliance-Questionnaire-Rheumatology (CQR)-19.Patients and MethodsA cross-sectional study was conducted in the Rheumatology clinic of Siriraj hospital from October 2020 to March 2022. Literate patients diagnosed with rheumatoid arthritis and aged ≥ 18 years old were included. Participants completed the Thai CQR-19 at baseline and during a follow-up visit. A pill count at the follow-up visit indicating that ≤ 80% of prescribed pills were taken was defined as poor compliance. Feasibility was assessed by the time to completion and the number of missing questions.Results156 participants were enrolled and 88% were in good compliance. The sensitivity of the CQR-19 to detect good compliance was 78.2% and the specificity was 27.8%. The Thai CQR-19 showed moderate agreement (Gwet’s AC1= 0.61, p < 0.01) with 72.2% agreement against pill counts. The Thai CQR-19 had good internal consistency (Cronbach’s alpha = 0.83) with moderate test-retest reliability (intraclass coefficients = 0.64, 95% CI 0.54–0.73; p < 0.05). There was a weak correlation between the Thai CQR-19 and disease activity (rs = 0.20, p < 0.05), and no correlation with functional disability (rs = 0.09, p = 0.25). The median (IQR) completion time was 4.42 (3.25–6.16) minutes and 114 (73%) completed all 19 questions.ConclusionThe Thai version of CQR-19 is a valid and reliable tool to assess medication compliance in Thai patients with RA. To ensure completeness and accuracy, this questionnaire may be administered by interview.