Introduction: Understanding hypertension is essential for its effective treatment and management. This study aims to assesse the knowledge level of hypertensive patients at commune health centers in Thua Thien Hue provinceand identify influencing their’ knowledge of hypertension. Methods: A cross-sectional approach was employed in this study. Hypertension knowledge was assessed using the Hypertension Knowledge - Level Scale (HK-LS) by SB Erkoc, while demographic details, lifestyle, clinical characteristics, medication adherence, and patient’s beliefs about mediicne were also collected. The analysis involved the use of the Chi-square test, t-test, and multiple logistic regression model in SPSS 27.0 software to examine relevant factors. Results: A total of 355 participants took part in the study, with women constituting 55.5%. Only 35.2% of patients demonstrated a high level of knowledge about hypertension. The mean knowledge score was 13.8 (standard deviation: SD = 4.9). This score was significantly higher in the high knowledge group (mean = 18.3, SD = 1.2) compared to the low knowledge group (mean = 11.3, SD = 4.3), with p < 0.001. Education level, ethnicity, monitoring of blood pressure at home, and patient beliefs about medicine were identified as significant factors associated with knowledge about hypertension. Conclusions: The study reveals a low proportion of hypertensive patients with a high level of knowledge at commune health centers in Thua Thien Hue province. Factors such as education level, ethnicity, home blood pressure monitoring, and patients’ beliefs about medicine were significantly associated with knowledge about hypertension. Coordinated interventions, including patient education and addressing medication beliefs, are essential to enhance treatment outcomes. Key words: knowledge, hypertension, blood pressure, beliefs about medicine.