Introduction: By the end of 2013, Brazil has implemented treatment as prevention (TasP) to every person living with HIV (PLWHA) regardless of their CD4 count, aimed at the reduction of HIV transmission. The HIV/AIDS epidemic is unevenly distributed across the territory, being concentrated in capital cities and along the coast. Methodology: The following public information systems were used in this study: Laboratory Tests Control System (SISCEL), Medication Logistics Control System (SICLOM), Notifiable Diseases Information System (SINAN) and Mortality Information System (SIM). Estimations of people who were linked to both public and private HIV health care services were considered. Results: By the end of 2012, 718,000 individuals were living with HIV/AIDS (LWHA) in Brazil and it was estimated that 74% of them were linked to care, of which 313,000 were on ART. Approximately 33% (236,000) of people LWHA had viral load suppression (≤50 copies/ml) and considering those who were on ART, suppression was 76%. Remarkable regional differences in suppression were found. Whilst VL suppression among those who were on ART in the South Region was 77%, in the North Region suppression does not reach 70%. Conclusions: HIV/AIDS epidemic in Brazil follows the standard of its social disparities. The poorer the region, the lower the adherence to treatment and its effectiveness. The implementation of the new strategies in different steps of the cascade as well as the focus on regional hotspots may be the key tools to properly confront the current HIV/AIDS epidemic. O111–Figure 1