Medical College Research Articles

Genetic susceptibility and clinical features of CYP2D6 associated with systemic lupus erythematosus in a Chinese population.

This study aims to explore possible susceptibility genes and clinical features for systemic lupus erythematosus (SLE) patients in a Chinese population. Expanding on the results of a prior single-center observational study involving 60 systemic lupus erythematosus patients, a subsequent single-center prospective observational study was conducted on SLE patients undergoing treatment at Nanfang Hospital Affiliated to Southern Medical University from 2021 to 2023. The identification process for drug-related target genes entailed an extensive search across PharmGKB (https://www.pharmgkb.org/), the Clinical Pharmacogenetics Implementation Consortium (CPIC),and PubMed literature databases, to pinpoint common drugs and target single nucleotide polymorphisms(SNPs)for SLE. Blood samples were individually collected and genotyped using MassARRAY® high-throughput nucleic acid mass spectrometry. Genotype frequency differences were assessed through Chi-square tests against both the larger East Asian population as well as kidney transplant recipients. Data collection relied on electronic medical records, encompassing demographic details(age, gender),medication regimens(hormones, NSAIDs, hydroxychloroquine, DMARDs, biologic agents, stomach medications, calcitriol, etc.),laboratory indicators(RF, Anti-CCP antibody, ESR, CRP, anti-ANA antibodies, dsDNA antibodies, anti-SM antibodies, S m. RNP antibodies, A LT, ALB, CR, UA, WBC, PLT, HGB, Ca, K, Glu, CHOL, TG, LDL-C, HDL-C) and lupus activity scores(SLEDAI-2K). Possible disease susceptibility genes were categorized, and SPSS26 software facilitated statistical analyses. The research encompassed a total of 137 SLE patients along with 50 SNPs. After conducting statistical analyses, it emerged that there existed significant disparities in CYP2D6 gene (rs1065852) distribution when compared against allele mutation rates within both East Asian populations (p < .05) and kidney transplant patients(p < .05). Wild-type gene (GG) constituted 14% of cases while mutant gene (GA + AA) constituted 86%. Allele mutation rate (A63.6%) was significantly higher among SLE patients (RR = 0.802; p = .0355). Furthermore, the variant rs1065852 genotype (GA + AA) demonstrated significant associations with lower CRP levels, higher HGB levels, and higher HDL-C levels (p < 0 0.05). The metabolic enzyme CYP2D6 may be used as susceptibility gene for predicting systemic lupus erythematosus and are correlated with CRP and other indicators.

Development and validation of a nomogram for predicting the interstitial fibrosis and tubular atrophy in patients with lupus nephritis.

Interstitial fibrosis and tubular atrophy (IFTA) were frequent histologic features of lupus nephritis (LN), and LN patients with IFTA have poor renal outcomes. In this study, we aimed to construct prediction models for the IFTA in LN patients. This retrospective study included 303 patients with biopsy proven LN at the Affiliated Hospital of Qingdao University and Union Hospital of Fujian Medical University. The participants were randomly divided into development and validation cohorts. They were further divided into IFTA and non-IFTA groups. The least absolute shrinkage and selection operator (LASSO) regression model with laboratory test results collected at the time of kidney biopsy was used to optimize feature selection for the risk model. Multivariable logistic regression analysis was applied to build a predicting model incorporating the feature selected in the LASSO regression model. Discrimination, calibration, and clinical usefulness of the predicting model were assessed using the C-index, calibration plot, and ROC curve analysis. Internal validation was assessed using the bootstrapping validation. A nomogram for individual assessment was constructed based on the preferable model. Predictors contained in the prediction nomogram included age, body mass index (BMI), mean arterial pressure (MAP), logANA, C3, eGFR and serum uric acid. The model displayed good discrimination with a C-index of 0.794 (95% CI 0.734-0.854) and good calibration. High C-index value of 0.857 (95% CI 0.776-0.938) could still be reached in the interval validation. A nomogram model based on the LASSO model was created for producing a probability score of IFTA in LN patients. With excellent predictive abilities, the nomogram may provide a simple and reliable tool to distinguish LN patients with IFTA and helps physicians make clinical decisions in their comprehensive assessment.

Future healthcare professionals on working conditions in Poland: perspective of medical university students.

Students of medical universities, future employees, will have an impact on the shaping healthcare system. It is important to know and understand their opinions on the factors affecting working conditions and, consequently, changes necessary to improve effectiveness of health care. Students' expectations can contribute to the changing working conditions for graduates and bring added value to health system redefinition. The study used factor analysis to check whether its use was justified. Reliability analysis was performed and structure indicators were determined for each question. The anonymous survey was conducted from September 2017 until March 2018; 1205 students were randomly selected for the sample. Eighty percent of the students declared interest in healthcare changes, >50% reported that the main factors influencing the work were competencies, financing, medical equipment and organization. Over 90% of the respondents indicated too long wait times for an appointment with a specialist and admission to hospital as the reason for the low efficiency of healthcare, whereas >80% of the survey participants considered insufficient funding to be a barrier. The need for changing the financing scheme was underlined by >90% of the students, and of health priorities by about 80%. Approximately 71% of the respondents were in favour of limiting the role of government in decision-making processes and introducing changes into the education system. Students' views on organizational and financial factors of working conditions can contribute to improvement in systemic solutions at both micro and macro levels. Limiting the role of politicians in planning and implementing reforms can motivate employees to be more creative and decisive. Analysis of opinions can bring added value to health policy and systemic changes and should be extended by further research results after the COVID-19 pandemic. Students' interest in healthcare reform encourages reflection on enriching education with managerial skills. Med Pr Work Health Saf. 2024;75(4):321-332.

Reticulocyte haemoglobin content in the differential diagnosis of iron deficiency anaemia and thalassemia traits in pregnancy

Background: Iron deficiency anaemia (IDA) and thalassemia traits are the common conditions of microcytic hypochromic anaemia in pregnant women. However, the laboratory tests to differentiate them are expensive. The reticulocyte haemoglobin (Ret-Hb) test is relatively cheap. This study aimed to assess whether Ret-Hb can differentiate IDA from thalassemia traits in pregnant patients. Method: This cross-sectional study was conducted in the Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2023 to February 2024. We recruited pregnant women aged 18 to 40 through antenatal visits in the Obstetrics and Gynecology Department. Microcytic hypochromic anaemia was diagnosed by complete blood counts, IDA by iron profile and thalassemia traits by haemoglobin electrophoresis. Ret-Hb was measured using the flow cytometric method. Ninety pregnant women—30 each with IDA, thalassemia traits and healthy individuals—were enrolled. Result: The mean age was 27 years. The IDA patients had significantly (P&lt;0.001) lower levels of Ret-Hb (mean 18.1, standard deviation 3.2 pg) compared to thalassemia traits (20.8, 2.2 pg) and healthy pregnant women (29.2, 1.9 pg). Using a Ret-Hb cut-off point of 19 pg, the test had 86.7% sensitivity and 53.3% specificity to differentiate thalassemia traits from IDA. Conclusion: Ret-Hb could be considered a diagnostic test to differentiate thalassemia traits from IDA in clinical settings before expensive confirmatory tests are performed.

Quality of Life After Abdomioperineal Resection for Rectal Carcinoma

Background: Abdominoperineal resection (APR) has long been a standard treatment for rectal cancer, particularly for tumors located very distally or in patients with poor sphincter function. Despite the rise of sphincter-sparing techniques, APR remains essential in certain cases. This study aims to evaluate the impact of APR on the quality of life (QoL) in rectal cancer patients. Objective: To assess the quality of life in rectal cancer patients following APR, focusing on physical, psychological, sexual, and social functioning. Method: This prospective observational study was conducted at Sher-e-Bangla Medical College &amp; Hospital, Barisal, over six months (July-December 2015). Patients who underwent APR for rectal cancer and were at least three months post-surgery were included. QoL was evaluated based on patients' self-assessments across four dimensions: physical, psychological, sexual, and social functioning. Result: The study included patients with a mean age of 48 years (range: 23-75 years), with 40% being early middle-aged (31-40 years). Stoma-related issues were reported by 56% of patients, while 64% experienced odor problems. Psychological distress was prevalent, with 52% feeling discomfort, 44% experiencing depression or anxiety, and 12% reporting suicidal tendencies. Sexual dysfunction was significant, affecting 55% of men, with 83.8% completely impotent. Social functioning was compromised, with 42% reducing social activities. Overall, 24% of patients rated their QoL as poor, 14% as extremely poor, 26% as average, and 36% as good. Conclusion: Rectal cancer patients post-APR experience considerable limitations across all QoL dimensions, underscoring the need for targeted interventions to improve their overall well-being.

Dexmedetomidine leads to the amelioration of stress response to surgery

Objectives: To determine the impact of intravenous Dexmedetomidine (Dex) administered perioperatively on stress response markers in patients undergoing ENT surgeries. Methods: This randomized interventional study was conducted at POFs Hospital and NUMS affiliated WMC, Wah Cantt, in collaboration with IIMC Rawalpindi, Pakistan, from October 2021 to April 2022. One hundred patients aged between 15-60 years, after satisfying the inclusion standards were randomly divided into two groups C and D. Group-C (n=50) received normal saline in addition to the standard anesthesia protocol. The intervention Group-D (n=50) was administered 1µg/kg dexmedetomidine hydrochloride intravenously over 10 minutes just before the induction followed 0.5μg/kg/hr as maintenance dose till the end of surgery. Serum inflammatory biomarkers (interleukins-6, TNF-α and cortisol) were measured in blood samples in both groups, taken at 0 (T0), 30 minutes(T1), and two hours (T2) time intervals and analyzed by using Enzyme-linked immunosorbent assay (ELISA). Data was statistically analyzed using SPSS 23. Results: The patients receiving Dex showed marked decrease in serum levels of cortisol, TNF- α and interleukins-6, from 139.73 to10.18, 99.51 to 0.96 and 85.09 to 0.96 respectively. Comparison between C and D groups revealed significant differences (p≤0.05) in these serum biomarkers. Conclusions: In the present study, intravenous Dex suppressed the intraoperative rise in levels of cytokine secretion and enhanced smooth recovery with no incidence of nausea and vomiting. These effects could be attributed to the anti-inflammatory effects of dexmedetomidine. Iranian Registry of Clinical Trials reference: IRCT20230824059251N1. Abbreviation:ENT: Ear, Nose and Throat, BMI: Body Mass Index, MAC: Monitored Cared Anesthesia, ASA: American Society of Anesthesiologists, SPSS: Statistical Package for Social Sciences, SD: Standard Deviation, PONV: Postoperative Nausea and Vomiting, OT: Operation Theater, POFs: Pakistan Ordinance Factories, WMC: Wah Medical College, IIMC: Islamic International Medical College, NUMS: National University of Medical Sciences. doi: https://doi.org/10.12669/pjms.40.9.8792 How to cite this: Ajmal K, Waheed A, Farooqi R, Mansoor Q. Dexmedetomidine leads to the amelioration of stress response to surgery. Pak J Med Sci. 2024;40(9):---------. doi: https://doi.org/10.12669/pjms.40.9.8792 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Assessing Initial Functional Outcomes Following Arthroscopic Release for Stiff Shoulder in Periarthritis Shoulder

Adhesive capsulitis can manifest as either primary/idiopathic or secondary, often linked to systemic illnesses. Primary adhesive capsulitis is characterized by limited range of motion without underlying systemic or precipitating shoulder conditions and lacks intrinsic pathology. In contrast, secondary frozen shoulder is associated with identifiable intrinsic factors such as diabetes, thyroid disorders, cardiac disease, stroke, prolonged immobilization, trauma, and rotator cuff disease. Our study aims to assess the initial functional outcomes, average recovery duration, and related comorbidities in arthroscopic release for adhesive capsulitis of the shoulder.The study was carried out at the Department of Orthopedics in Saveetha Medical College and Hospital, Thandalam, spanning from June 1, 2022, to June 31, 2023. It comprised 30 patients diagnosed with adhesive capsulitis who met specific criteria. The treatment regimen consisted of Arthroscopic Release followed by intensive physiotherapy and prescribed home exercises. Follow-up appointments were scheduled at regular intervals to track progress, using assessment tools like the UCLA Score and VAS score, and all data were meticulously recorded in a standardized proforma.30 individuals who met specific criteria were diagnosed with adhesive capsulitis. Of these, 12 out of 18 participants were female, and 16 patients experienced more frequent impairments on the left side. The average age of the patients was 65 years, ranging from 57 to 78 years old. Stage 2 was the most common among the approximately 19 patients. Prior to surgery, the UCLA score had a mean of 23, ranging from 18 to 26, while the mean preoperative VAS score was 8, with a range of 7 to 9. Following surgery, significant improvements were observed in the UCLA score, ranging from 26 to 35, and the post-operative VAS score ranged between 2 and 5. In our study, arthroscopic release appears as a safe procedure with favourable postoperative results. This consequently enables early mobilization of the shoulder joint and decreases complication rates.

Exploring the Potential of Turmeric as a Natural Antibacterial Agent: In Vitro Evaluation of Crude Paste and Aqueous Extract

Background: There is growing concern in the use of natural antimicrobial compounds due to the emergence of antibiotic resistance. One such contender is turmeric (Curcuma longa), an herb known for its usage in medicine for centuries; nowadays, however, its prospects in pharmacology are being actively discussed. Since access and utilization of modern health care is scarce in Bangladesh, such natural cures are worth researching. Objective: To assess the in vitro antibacterial activity of turmeric’s crude paste and aqueous extract against Staphylococcus aureus and Escherichia coli. Methods: The study was carried out in the Department of Pharmacology with the collaboration of Department of Microbiology, Mymensingh Medical College, Bangladesh, over a period of one year from July 2010 to June 2011, and it consisted of three experiments: Effects of crude turmeric paste incorporated in nutrient agar media, Minimum Inhibitory Concentration of Aqueous Turmeric Extract and Amikacin by broth dilution method, and Subculture method to confirm bactericidal effect. Results: CTP demonstrated effective growth of S. aureus at 10% concentration and E. coli at 30% concentration. The MIC of ATE was found to be 800 μg/ml for S. aureus and 2000 μg/ml for E. coli. The MIC for amikacin was 10 μg/ml for both organisms. These effects have been further substantiated in subculture studies regarding their bactericidal properties. Conclusion: From the findings of the current study, it is evident that both turmeric and its crude paste had profound antibacterial effects against S. aureus and E. coli, though the effect of crude paste was observed to be stronger than that of the aqueous extract. Although not as strong as Amikacin, its organic nature and possibility of side effects make it worth pursuing. Hence, this work adds to the literature on the fact that turmeric has health benefits as highlighted by traditional medical practice and points to the need to find new natural sources of .............

Comparative Study of Circumcision

Background: Male circumcision is a significant practice in Muslim tradition and is widely performed for religious reasons, especially in Muslim-majority countries like Bangladesh. Objective: This study aims to compare different surgical techniques of male circumcision in children and highlight the complications arising from procedures performed by non-qualified practitioners Quack (Hazam) in Bangladesh. Method: A comparative study was conducted at Sher-E-Bangla Medical College Hospital, Barisal, from December 2022 to February 2023. Two hundred male children were included, with 100 circumcised by pediatric surgeons using guillotine and dorsal slit techniques, and 100 presented with complications from circumcision performed by non-qualified quacks. Results: Out of 200 children, 50% underwent circumcision by quacks using the guillotine method, resulting in complications such as infection (10%), bleeding (4%), glans injury (1%), urethrocutaneous fistula (1%), and incomplete circumcision (4%). Among the 100 children circumcised by pediatric surgeons, complications were minimal, with 2% minor infections, 2% minor bleeding, 1% respiratory distress, and 1% vomiting. The guillotine and dorsal slit techniques performed in the hospital setting demonstrated significantly lower complication rates compared to procedures conducted by quacks. Conclusion: Circumcision performed by trained medical professionals under aseptic conditions is safe and associated with fewer complications. Public awareness and discouragement of procedures by quacks are essential to prevent circumcision mishaps.

Outcome of Empirical Antibiotic Prescription for the Treatment of Community Acquired Pneumonia

Background: The primary cause of illness and death in Bangladesh is community acquired pneumonia (CAP). Many hospitals in Bangladesh lack the resources to perform sputum cultures and sensitivity tests, making it difficult to identify the etiological agent of an infection. As a result, antibiotics are prescribed on a "empirical basis" rather than as part of a specific anti microbial treatment. The optimal antibiotic for treating CAP should be chosen using an empirical approach. Objective: The purpose of this study is to evaluate the effectiveness of various empirical antibiotic choices in the management of CAP. Methods: Eighty-two patients with CAP were included in this prospective observational research at a tertiary medical college hospital in Bangladesh. Inclusion and exclusion criteria were used to choose patients. Chest x-rays confirmed the diagnosis of CAP. The antibiotic was chosen based on clinical experience, which is an empirical method. The majority of patients received a combination antibiotic, whereas the remaining handful received monotherapy. The result served as an evaluation of the empiricism used in selecting the antibiotic. During the research, data were recorded in standardized formats. SPSS was used for the statistical analysis. Results: A total of 82 people were treated, and of them, 62 (or 76%) were men and 20 (or 24%) were women. The average age was 54.4% (9.6%). The round of antibiotics was supposed to last for a week. There were no unwanted medication reactions. No cases of lung abscess or parenchymal damage to the lungs occurred, and only one patient had paraneumonic effusion. Every single person made a full recovery. Conclusion: In many hospitals in Bangladesh, the choice of antibiotic for treating CAP is made on a "empirical" basis. Selecting an appropriate antibiotic requires better sputum culture and sensitivity testing in hospital labs.

A Short-Term Study of 18 Cases of Distal Femur Fractures Managed By Locking Compression Plate [Lcp] Using A Less Invasive Skeletal Stabilisation System [LISS

Distal femur fractures have traditionally been the most challenging to treat. Restoring full motion and function to the knee may be challenging due to these fractures' proximity to the knee joint. Regardless of the treatment method, comminution, damage of soft tissue, fracture extension into the knee joint, and related injury to the quadriceps mechanism frequently concludes in suboptimal outcomes. The early surgical fixation notion, increased implant availability, early postoperative knee joint immobilization, and a better understanding of damage patterns have all significantly improved the patient's functional result. Our study focuses on distal femur fractures managed by LCP [locking compression plate] using a less invasive skeletal stabilization system [LISS]. This is a retrospective research of 18 cases of distal femur fractures in adults who had LCP treatment with the LISS. The operation at Saveetha Medical College and Hospital in Chennai runs from January 2021 to January 2022. All types of intercondylar and supracondylar fractures are included. Children's fractures and pathological fractures were not included. Age distribution, side of injury, sex distribution, anatomy of injury, mechanism of injury, damage grading, subtype of fracture, concomitant injuries, and open fractures were the parameters used to assess the cases. AP and lateral views of the X-ray were taken. A thorough preoperative workup was completed. Every case was scheduled for surgery as soon as feasible. External fixators were used in the initial treatment of complicated cases. Patients underwent locking compression plate (LCP) fixation with the LISS. Radiological examination immediately following surgery, four weeks, six weeks, eight weeks, twelve weeks, four months, and every six months for a maximum of one year.The age range of the patients was 21 to 70 years, with a mean age of 30 years. A maximum incidence of fractures was noted in individuals aged 40 to 60. Males accounted for the majority of the 18 cases, with a female-to-male ratio of 3:5. Our series was predominantly right-sided. The most frequent cause of injury has been traffic accidents. Throughout the research period, no patients were lost to follow-up. Of the eighteen cases, the majority involved distal femur fractures, with intercondylar extension accounting for a higher number of cases, and isolated supracondylar fractures following. A head injury was present in one case, and acetabular fracture in another, a Boxer’s fracturein a third case, and 2 open fractures (1 compound grade III A, the other compound grade II). The fractures took an average of 13.3 weeks to heal. It required an average of 15.3 weeks longer in cases of compound fractures. Less than six degrees of malalignment (varus, valgus) were present. Every patient exhibited optimal articular alignment.Excellent outcomes were obtained with the LISS, which combines appropriate physiotherapy with an LCP (angle stable build). In principle, an LCP implant is the best option for fractured and osteoporotic bones. In summary, the use of LCPs in the LISS appears to yield superior outcomes when managing distal femur fractures.

Outcome Comparison of Multidirectional Locked Nailing and Plating for Distal Tibial Fractures: A Comparative Analytical Study

Introduction: This comparative analytical study explores the functional outcomes of treating distal tibial fractures using multidirectional locked nailing and plating. Distal tibia fractures, resulting from high-energy trauma, pose challenges due to soft tissue damage, infection risks, and potential unfavorable outcomes. Our study seeks to evaluate and contrast the functional results of treating distal tibial fractures using multidirectional locked nailing versus plating techniques. Materials and Methods: Conducted at Saveetha Medical College and Hospital from August 2022 to October 2023, the study involved 20 cases meeting specific criteria. Adult patients (18-70 years) with closed fractures and grade I compound fractures of distal tibia (AO type 43-A1, 43-A2, and 43-A3) were included. The cases were evenly divided between multidirectional locked nailing and plating groups. Subsequent evaluations, comprising both radiographic and clinical analyses, were performed at 6, 12, and 24-week intervals. Results: The study encompassed various parameters, including age distribution, causes of fractures, weight-bearing protocols, and joint movements. Multidirectional locked nailing demonstrated a shorter fracture union time, promoting earlier weight-bearing and functional exercises. Ankle and knee scores in this group indicated successful joint function restoration but with a higher malunion rate. Plating exhibited a lower malunion rate but a prolonged time to union. Complications, including superficial infections and wound dehiscence, were observed, emphasizing the importance of postoperative monitoring. Despite challenges, the plate group achieved satisfactory functional outcomes, highlighting fair to good ankle scores and full knee movement in all cases. Conclusion: In conclusion, the study underscores the distinctive advantages and considerations of each treatment approach. Multidirectional locked nailing facilitates faster union and joint function restoration but carries a higher malunion risk. Plating, with a lower malunion rate, requires meticulous postoperative care. The choice between the two methods should be individualized, considering patient-specific factors, fracture characteristics, and the surgeon's expertise. This research contributes valuable insights for informed decision-making in distal tibia fracture treatment.

To Assess the Functional outcome of Inflammatory arthritis of Knee following a Total Knee Replacement in a Tertiary Care Centre

Introduction : Inflammatory arthritis, particularly RA, can lead to significant joint destruction and functional impairment, necessitating interventions such as TKA. Despite medical therapy, severe joint damage may occur, warranting surgical intervention. This study assesses the functional outcomes post-TKA in patients having inflammatory arthritis. Materials and Methods: Patients who received TKA for inflammatory arthritis were included in this prospective observational cohort research, specifically RA, between 2019 and 2023 at Saveetha Medical College, Chennai. Clinical, radiological, and functional results have been assessed using the American Knee Society scoring system. IBM SPSS version 22.0 was utilized for analysis of data, p &lt; 0.05 is the threshold for statistical significance. Results:Twenty TKAs have been performed for RA, with all patients successfully followed up. The mean age of the patients was 58.5 years, and the majority were female. Before TKA, the average length of RA was 7.24 years, and all patients were in stage IV illness. Preoperative and postoperative knee society scores showed significant improvement, with average scores of 58.15 and 96.15, respectively. Functional scores also demonstrated substantial enhancement post-TKA, with an average increase of 130%. Radiological assessment revealed no evidence of lysis in any patient. Conclusion: Significant inverse relationship among the postoperative functional score and the length of the disease and the involvement of other joints. Utilizing the American Knee Society and functional scoring systems allows for objective prediction of surgical success. This can motivate surgeons and treating physicians to enhance care for RA patients.

Minimally Invasive Plate Osteosynthesis for Comminuted Fractures of Long bones: A Prospective Study on Outcomes and Complications

The surge in comminuted bone fractures, attributed to modern lifestyles and increased trauma incidents, poses significant challenges in management. Traditional open reduction and plating methods, while effective, are associated with drawbacks like delayed union and higher infection rates. The evolution of MIPO (Minimally Invasive Plate Osteosynthesis) seeks to overcome these limitations. The potential effects of MIPO in the management of severely comminuted long bone fractures are investigated in this work. The Saveetha Medical College's Department of Orthopaedics carried out a prospective study from March 2022 to March 2024. Patients aged 20 to 60 with fractures of the femur, tibia, and humerus resulting from road traffic accidents were included. The AO Fracture classification system was utilized, and MIPO techniques were employed for fixation. Clinical and radiological assessments were conducted at various follow-up intervals. Statistical analysis using IBM SPSS Version 22.0 assessed outcomes, with a P-value&lt;0.05 countedas significant. MIPO was performed on twenty-four male patients, ages averaging 34.4 years, for severely comminuted fractures. The distal 1/3 of the femur, the tibia, and the humerus shaft were among the fractures. Union was rapid in 15 cases, with delayed consolidation in two requiring secondary bone grafting. Functional outcomes assessed using the Neer–Grantham–Shelton Criteria, demonstrated excellent outcomes- 65%, good- 30%, and fair- 5% of events. Complications included infection (5%), wound gaping (5%), joint stiffness (25%), and limb length discrepancy (20%). This study reinforces MIPO as a promising approach for severely comminuted fractures, showcasing excellent union rates and functional outcomes. Studies highlight its advantages in preserving soft tissue and periosteal circulation. The shift from anatomic reduction to optimal stability in such fractures aligns with current trends. Complications, though present, are manageable. The study contributes to the growing body of evidence supporting MIPO, emphasizing its potential advantages in minimizing surgical trauma and maintaining biological stability. Further research, including comparative studies and exploration of other fixation methods, is warranted for a comprehensive understanding of MIPO's role in fracture management.

Functional Outcome of Perpendicular Plating Versus Parallel Plating In The Management Of Distal Humerus Fractures- A Comparative Study

Distal humerus fractures are quite uncommon but pose significant challenges in management due to their complex anatomy and varied fracture patterns. Surgical intervention, particularly using plate fixation, is often necessary to achieve stable fracture union and restore functional elbow mobility. This prospective comparative study aimed to analyse the outcomes of distal humeral fracture management using perpendicular and parallel plating techniques. Thirty patients with distal humeral fractures underwent osteosynthesis with either perpendicular or parallel plating between November 2020 and October 2022 at Saveetha Medical College and Hospital in Chennai. The Mayo Elbow Performance Score has been utilized to measure the following assessment parameters: pain, radiological, stiffness and clinical union, and functional elbow ability at 6 weeks, 3 months, 6 months, and 1 year after the surgery.Both techniques yielded satisfactory outcomes in terms of fracture union and functional recovery. However, complications and biomechanical properties differed significantly between the two methods. Parallel plating demonstrated superior stability and resistance to plastic deformation, particularly in osteoporotic bone, suggesting potential advantages in managing comminuted distal humerus fractures with an intraarticular component. This study contributes valuable insights into the optimal management strategies for distal humeral fractures and highlights the importance of considering individual patient factors and fracture characteristics when selecting the most suitable surgical approach. Additional investigation is necessary to verify these results and improve methods of treatment for this difficult kind of fracture.

Incidence of Cervical Intraepithelial Neoplasia in the Outpatient Department: A Study at Islami Bank Medical College Hospital, Rajshahi

Incidence of Cervical Intraepithelial Neoplasia in the Outpatient Department: A Study at Islami Bank Medical College Hospital, Rajshahi

Combined DeRitis ratio and alkaline phosphatase on the prediction of portal vein tumor thrombosis in patients with hepatocellular carcinoma

Portal vein tumor thrombosis (PVTT) is one of the common complications of HCC and represents a sign of poor prognosis. PVTT signifies advanced liver cancer, deteriorating liver function, and heightened susceptibility to intrahepatic dissemination, systemic metastasis, and complications related to portal hypertension. It is important to seek novel strategies for PVTT arising from HCC. Portal vein tumor thrombus (PVTT) in hepatocellular carcinoma (HCC) represents a worse liver function, less treatment tolerance, and poor prognosis. This study aimed to investigate the diagnostic value of the combination of the DeRitis ratio (AST/ALT) and alkaline phosphatase (ALP) index (briefly named DALP) in predicting the occurrence risk of PVTT in patients with HCC. We performed a retrospective study enrolling consecutive patients with HCC from January 2017 to December 2020 in Hebei Medical University Third Hospital. ROC analysis was performed to estimate the predictive effectiveness and optimal cut-off value of DALP for PVTT occurrence in patients with HCC. Kaplan–Meier analysis revealed the survival probabilities in each subgroup according to the risk classification of DALP value. Univariate and multivariate Logistics regression analyses were applied to determine the independent risk for poor prognosis. ROC analysis revealed that the optimal cut-off value for DALP was 1.045, with an area under the curve (AUC) of 0.793 (95% CI 0.697–0.888). Based on the DALP classification (three scores: 0–2) with distinguishable prognoses, patients in the score 0 group had the best prognosis with a 1-year overall survival (OS) of 100%, whereas score 2 patients had the worst prognosis with 1-year OS of 72.4%. Similarly, there was a statistically different recurrence-free survival among the three groups. Besides, this risk classification was also associated with PVTT progression in HCC patients (odds ratio [OR] 5.822, P < 0.0001). Pathologically, patients in the score 2 group had more advanced tumors considering PVTT, extrahepatic metastasis, and ascites than those in score 0, 1 groups. Moreover, patients with a score of 2 had more severe hepatic inflammation than other groups. Combination of DeRitis ratio and ALP index presented a better predictive value for PVTT occurrence in patients with HCC, contributing to the tertiary prevention.

Comparison of Superselective Renal Artery Embolization versus Retroperitoneal Laparoscopic Partial Nephrectomy in Ruptured Hemorrhagic Renal Angiomyolipoma: A Single-Center Study

Purpose: To analyze the clinical efficacy of superselective renal artery embolization and retroperitoneal laparoscopic partial nephrectomy for the treatment of ruptured hemorrhagic renal angiomyolipoma and to provide a reference for the selection of treatment methods for ruptured hemorrhagic renal angiomyolipoma. Methods: A retrospective analysis was conducted on the clinical data of 24 patients who were diagnosed with ruptured hemorrhagic renal angiomyolipoma at the Second Hospital of Tianjin Medical University between January 2019 and December 2021. Among them, 10 patients were treated with superselective arterial embolization (SAE), and 14 patients were treated with retroperitoneal laparoscopic part nephrectomy (RLPN). The differences between the two treatment methods in terms of hospital stay, hospital costs, anesthesia method, operation time, intraoperative blood loss, postoperative bed rest time, antibiotic dosage, postoperative complication rate, tumor diameter changes, creatinine value changes, hemoglobin value changes, tumor recurrence rate, and reoperation rate were compared. Results: All patients completed the treatment and were discharged. There were no significant differences in length of hospital stay, hospital costs, creatinine change values, or postoperative complication rates between the two groups (p &gt; 0.05). However, there were statistically significant differences (p &lt; 0.05) in surgical time (85.50 ± 19.94 min vs. 141.07 ± 76.33 min), intraoperative blood loss (21.50 ± 14.72 mL vs. 153.57 ± 97.00 mL), postoperative bed rest time (22.7 ± 1.56 h vs. 41.21 ± 3.57 h), preoperative hemoglobin levels (94.7 ± 23.62 g/L vs. 113.79 ± 17.83 g/L), and hemoglobin changes (−6.60 ± 10.36 g/L vs. −15.21 ± 8.79 g/L) between the two groups. Both groups of patients had an average follow-up period of 22 months, and patients in the SAE group had a mean reduction of 3.33 cm in tumor diameter within the follow-up period compared with the pre-embolization period (p &lt; 0.05). None of the patients in the SAE group experienced rebleeding, and there was no tumor recurrence in either group. Conclusion: SAE and RLPN are effective treatments for ruptured renal angiomyolipoma with good outcomes. Furthermore, compared to RLPN, SAE offers advantages such as simplicity of operation, minimal trauma, shorter surgical time, minimal impact on hemoglobin levels, shorter bed rest time, faster postoperative recovery, and maximal preservation of renal units.

Orthostatic intolerance during early mobilization following thoracoscopic lung resection: a prospective observational study

BackgroundEarly postoperative mobilization is important for enhanced recovery but can be hindered by orthostatic intolerance. However, study on postoperative orthostatic intolerance in thoracoscopic lung resection is limited. Thus, this investigation aims to examine the prevalence and variables contributing to orthostatic intolerance on the first day following thoracoscopic lung cancer resection.MethodsA prospective observational study was conducted from February 01 to May 05, 2023, at the First Affiliated Hospital of Chongqing Medical University. Typically, 215 subjects subjected to thoracoscopic lung resection were enrolled in this study. Their general information, disease, and treatment information were collected, and the occurrence of orthostatic intolerance was recorded.ResultsTypically, 64 patients (29.77%) demonstrated orthostatic intolerance during early mobilization, and 43.75% failed to walk. The prevalence of nausea, dizziness, and impaired vision was 60.94%, 92.19%, and 25.00%, respectively, and no patient experienced syncope. The factors shown to be independently linked with orthostatic intolerance were being female (OR = 2.98, 1.53 to 5.82) and high pain level during sitting (OR = 2.69, 1.79 to 4.04). Individuals with orthostatic intolerance had a longer postoperative hospital stay with a mean of 5.42 days against 4.25 days (p = 0.003).ConclusionsOrthostatic intolerance was prevalent following thoracoscopic lung cancer resection and affected patients’ capability to mobilize and prolonged postoperative hospitalization. Being female and having high pain levels during sitting were identified as independent factors for orthostatic intolerance. This suggests that more emphasis should be given to risky patients, and for these groups, we may optimize pain management to adjust the risk of emerging orthostatic intolerance, facilitating early mobilization and early postoperative rehabilitation.

Competency Approach in Nurse Training

In the current conditions of market relations, especially in the context of reforming the medical education system, it is necessary to change the quality of training of specialists in order to train demanded and competitive graduates of secondary vocational educational institutions using a competency approach. The competence approach contributes to the orientation of the young specialist to obtain theoretical knowledge, increasing the level of practical knowledge that a graduate of a medical college should have and his ability to master in the labor market. The opinion of medical college students about the knowledge and practical skills required by the graduate is important. To this end, a questionnaire survey of 84 medical college students was conducted. First-year students do not yet have a clear idea of ​ ​ the competence approach in the learning process and the importance of not only theoretical knowledge, but also clinical disciplines, practical communication skills. Students of the 3rd year have already formed an opinion about the importance of all subjects and motivation for future professional training. The introduction of a competency approach in the training of nurses makes it possible to conduct the educational process at a qualitative level, contributing to the training of highly qualified, competitive specialists in the medical labor market.