The paper characterizes the process of creation of medical infrastructure and first aid system to immigrant and indigenous people in Tashkent and the Tashkent district in the second half of the XIX – the beginning of the XX century by the imperial authorities. The purpose of the paper is to reveal the medical condition in the second half of the XIX – early the XX century in Turkistan, types and amount of medical care, which was provided to the indigenous population of the region, by studying biographical and source materials. The paper draws attention to the fact that initial medical assistance to the immigrant population and then the indigenous dwellers of the region were provided by surgeons who settled mainly in Tashkent and the major cities of Turkestan. I. P. Sheverdin was one of the first surgeons who founded the rural hospital in remote place of Tashkent district – village Tillyau in 1899 – 1903, whose asceticism and dedication the inhabitants of this village still remember. It is shown that medical services in Tashkent and the Tashkent district in the pre-revolutionary period developed slowly, which corresponds to the first stage of initiation of the indigenous population of the region to the modern achievements of medicine.