BackgroundPatient-reported outcomes of postdischarge functional status can provide insight into patient recovery experiences not typically reflected in trauma registries. Injuries may be characterized by a long-term loss of independence. We sought to examine factors predictive of patient-reported, postdischarge loss of independence in trauma patients. MethodsTrauma patients admitted to 1 of 3 level I trauma centers were contacted by phone between 6 to 12 months after hospital discharge to complete the Revised Trauma Quality of Life survey. Loss of independence was defined as a new need for assistance with at least one activity of daily living or transition to living in an institutional setting. Patients with severe traumatic brain injury or spinal cord injury were excluded. Multivariable logistic regression analyses were performed to identify predictors of loss of independence. Results801 patients were included. The median age was 65 (interquartile range: 46–76) years, 46.1% were female, and the median Injury Severity Score was 9 (interquartile range: 9–13). Two hundred seventy-one patients (33.8%) experienced a loss of independence, most commonly requiring assistance walking up stairs. The main predictors of loss of independence were persistent daily pain (odds ratio: 3.83, 95% confidence interval: [2.90–5.04], P < .001), length of hospital stay (odds ratio: 1.04, 95% confidence interval: [1.01–1.09], P = .021) and income below the national median (odds ratio: 1.46, 95% confidence interval: [1.12–1.91], P = .006). Perceived social support (odds ratio: 0.75, 95% confidence interval: [0.66–0.85], P < .001) was protective against loss of independence. ConclusionInjury is associated with a relatively high rate of long-term loss of independence. Ensuring adequate social support systems for patients postdischarge may help them regain functional independence after injury.