You have accessJournal of UrologyBenign Prostatic Hyperplasia: Evaluation and Symptoms1 Apr 2015MP71-12 INCREASE OF FRAMINGHAM RISK IS ASSOCIATED WITH SEVERITY OF LOWER URINARY TRACT SYMPTOMS: CONFIRMING RELATIONSHIP BETWEEN BOTH DISEASES Giorgio Ivan Russo, Tommaso Castelli, Salvatore Privitera, Eugenia Fragalà, Vincenzo Favilla, Giulio Reale, Daniele Urzì, Sebastiano Cimino, and Giuseppe Morgia Giorgio Ivan RussoGiorgio Ivan Russo More articles by this author , Tommaso CastelliTommaso Castelli More articles by this author , Salvatore PriviteraSalvatore Privitera More articles by this author , Eugenia FragalàEugenia Fragalà More articles by this author , Vincenzo FavillaVincenzo Favilla More articles by this author , Giulio RealeGiulio Reale More articles by this author , Daniele UrzìDaniele Urzì More articles by this author , Sebastiano CiminoSebastiano Cimino More articles by this author , and Giuseppe MorgiaGiuseppe Morgia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2625AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Cardiovascular diseases (CVD) and lower urinary tractsymptoms (LUTS) are health problems that are becomingmore prevalent in the aging population. Both share similar risk factors (e.g., age,diabetes, hypertension, obesity, smoking) but underlying pathophysiology is not well understood. The aim of this cross-sectional study is to evaluate the relationship between LUTS and CVD assessed by the Framingham score risk. METHODS Between September2010 to September 2014, 336 consecutive patients with BPH related LUTS were enrolled in this cross-sectional study. The patients with neurogenic bladder, previous pelvic surgery, urological cancers, hypogonadism were excluded from the study.Patients underwent physical examination and blood samples collection. LUTS of the patients were evaluated by culturally and linguistically validated versions of International Prostate Symptom Score (IPSS). LUTS severities were classified as mild (IPSS 0–7), moderate-severe (IPSS 8–35).The general 10-year cardiovascular disease Framingham risk,expressed as a percent, assesses risk of atheroscleroticCVDevents (i.e., coronary heart disease, cerebrovasculardisease, peripheral vascular disease, and heart failure) was calculated for each patients using age, high-density lipoprotein, total cholesterollevel, systolic blood pressure, antihypertensivemedication use, diabetes, and current smokingstatus. Individuals with low risk had 10% or less CHD risk at 10 years, with intermediate risk 10-20%, and with high risk 20% or more. RESULTS Median age was 67.0yrs (IQR: 61.0-72.0), median IPSS was 18.0 (IQR: 14.0-23.0), median PSA was 3.72ng/ml (IQR: 1.58-6.69), median prostate volume was 50.0 cc (IQR: 35.0-65.0), median Framingham risk was 17.0 (IQR: 12.0-21.0). As category Framingham risk increases, we observed higher IPSS (14.5 vs. 17.0 vs. 19.0; p<0.05), high IPSS-storage (7.5 vs. 8.0 vs. 8.5; p<0.05) and low IIEF-erectile function (23.5 vs. 23.0 vs. 16.0; p<0.05). Prostate volume significantly increase in intermediate Framingham risk vs. low risk (52.5 vs. 39.0; p<0.05). Linear regression analysis showed positive association between Framingham risk and IPSS (β= 0.16; p<0.01), IPSS-storage (β= 0.13; p<0.05) and IPSS-voiding (β= 0.14; p<0.01). Multivariate logistic regression analysis demonstrated that insulinemia (OR: 1.11 [1.04-1.19]; p<0.01) and Framingham score ≥ 10 (OR: 3.07 [0.99-9.47]; p<0.01) were independently associated with moderate-severe LUTS after adjusting with age, PSA and prostate volume. After adjusting for covariates intermediate Framingham risk (OR: 7.89 [1.98-31.51]; p<0.01) and high Framingham risk (OR: 2.59 [1.20-5.5]; p<0.05) were independently associated with moderate-severe LUTS. CONCLUSIONS In this cohort of patients, increase of Framingham risk was significantly associated with severity LUTS. This results strength the relationship between two different aspect of male health that must be investigated in order to reduce CVD risk in patients affected by LUTS. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e916 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Giorgio Ivan Russo More articles by this author Tommaso Castelli More articles by this author Salvatore Privitera More articles by this author Eugenia Fragalà More articles by this author Vincenzo Favilla More articles by this author Giulio Reale More articles by this author Daniele Urzì More articles by this author Sebastiano Cimino More articles by this author Giuseppe Morgia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...