You have accessJournal of UrologyProstate Cancer: Detection and Screening II1 Apr 20101854 THE IMPACT OF PROSTATE BIOPSY AND PERIPROSTATIC NERVE BLOCK ON VOIDING FUNCTION: A PROSPECTIVE PILOT STUDY Tobias Klein, Alexander Holz, Andreas Hinkel, and Joachim Noldus Tobias KleinTobias Klein More articles by this author , Alexander HolzAlexander Holz More articles by this author , Andreas HinkelAndreas Hinkel More articles by this author , and Joachim NoldusJoachim Noldus More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.1793AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate biopsy (bx) guided by transrectal ultrasound is the current standard procedure for the detection of prostate cancer. Saturation bx is an established option for patients with previously negative bx but persistent suspicion for cancer. The aim of our study was to assess the effect of multi-core bx and periprostatic nerve block (PPNB) on voiding function. METHODS Between September 2007 and January 2008 198 patients were enrolled in this prospective pilot study and randomly assigned to receive a 10-core bx with (n=71) or without (n=74) PPNB. Another 53 patients with a history of previously negative bx received a saturation bx (20 cores) with PPNB. The International Prostate Symptom Score (IPSS) was completed before, 1, 4, and 12 weeks after bx. Pain was analyzed utlilizing the Visual Analogue Scale (VAS). Patients were excluded from the study when prostate cancer was diagnosed. Change of the median IPSS (primary endpoint) within 3 months after bx and the impairment of quality of life due to urinary symptoms (secondary endpoint) were measured. The variables local anaesthesia, number of cores, pain score (VAS), and age were analyzed for an association with the endpoints. RESULTS The cancer detection rate was 40.4% (n=80). The median IPSS was significantly higher in all patients 1 week after bx. We found persistent differences compared to baseline both 4 and 12 weeks after bx in patients with saturation bx (p=0.007 and p=0.035, respectively). Patients with a 10-core bx and PPNB showed higher IPSS at week 4 and 12 but the difference was not significant (p>0.05). Quality of life due to urinary symptoms was significactly affected after 1, 4, and 12 weeks in the saturation bx group (p=0.001, p=0.003, and p= 0.010, respectively). Regression analyses revealed a significant correlation between impairment of voiding function and PPNB as well as multi-core bx (p<0.05). CONCLUSIONS Prostate bx in general causes voiding impairment. Moreover, saturation bx and the application of a PPNB seem to have a lasting impact on voiding function. Patients undergoing bx for the detection of prostate cancer have to be imformed about these side effects. Herne, Germany© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e720 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Tobias Klein More articles by this author Alexander Holz More articles by this author Andreas Hinkel More articles by this author Joachim Noldus More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...